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Prospective evaluat...
Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer
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- Mukama, Trasias (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Fortner, Renée Turzanski (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Katzke, Verena (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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visa fler...
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- Hynes, Lucas Cory (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Petrera, Agnese (författare)
- Research Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany
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- Hauck, Stefanie M. (författare)
- Research Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany
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- Johnson, Theron (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Schulze, Matthias (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam -Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- Schiborn, Catarina (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam -Rehbruecke, Nuthetal, Germany
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- Rostgaard-Hansen, Agnetha Linn (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49 DK-2100, Copenhagen, Denmark
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49 DK-2100, Copenhagen, Denmark
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- Overvad, Kim (författare)
- Department of Public Health, Aarhus University, Bartholins Alle 2, Aarhus C, Denmark
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- Pérez, María José Sánchez (författare)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,Andalusian School Of Public Health (EASP)
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- Crous-Bou, Marta (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard University,Bellvitge University Hospital-IDIBELL
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- Chirlaque, María-Dolores (författare)
- CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain
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- Amiano, Pilar (författare)
- CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain; Biodonostia Health Research Institute, Group of Epidemiology of Chronic and Communicable Diseases, San Sebastián, Spain
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- Ardanaz, Eva (författare)
- CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
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- Watts, Eleanor L. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Travis, Ruth C. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Sacerdote, Carlotta (författare)
- Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Via Santena 7, Turin, Italy
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- Grioni, Sara (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy
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- Masala, Giovanna (författare)
- Institute of Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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- Signoriello, Simona (författare)
- Dipartimento di Salute Mentale e Fisica e Medicina Preventiva, Vanvitelli University, Naples, Italy
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
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- Gram, Inger T. (författare)
- Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
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- Sandanger, Torkjel M. (författare)
- Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
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- Sartor, Hanna (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Radiology Diagnostics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Lundin, Eva (författare)
- Umeå University,Umeå universitet,Patologi
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- Idahl, Annika, 1965- (författare)
- Umeå University,Umeå universitet,Obstetrik och gynekologi
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- Heath, Alicia K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Dossus, Laure (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Kaaks, Rudolf (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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(creator_code:org_t)
- 2022-01-14
- 2022
- Engelska.
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Ingår i: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 126, s. 1301-1309
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer.Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we measured serum levels of 92 preselected proteins for 91 women who had blood sampled ≤18 months prior to ovarian cancer diagnosis, and 182 matched controls. We evaluated the discriminatory performance of the proteins as potential early diagnostic biomarkers of ovarian cancer.Results: Nine of the 92 markers; CA125, HE4, FOLR1, KLK11, WISP1, MDK, CXCL13, MSLN and ADAM8 showed an area under the ROC curve (AUC) of ≥0.70 for discriminating between women diagnosed with ovarian cancer and women who remained cancer-free. All, except ADAM8, had shown at least equal discrimination in previous case-control comparisons. The discrimination of the biomarkers, however, was low for the lag-time of >9–18 months and paired combinations of CA125 with any of the 8 markers did not improve discrimination compared to CA125 alone.Conclusion: Using pre-diagnostic serum samples, this study identified markers with good discrimination for the lag-time of 0–9 months. However, the discrimination was low in blood samples collected more than 9 months prior to diagnosis, and none of the markers showed major improvement in discrimination when added to CA125.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Mukama, Trasias
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Fortner, Renée T ...
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Katzke, Verena
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Hynes, Lucas Cor ...
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Petrera, Agnese
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Hauck, Stefanie ...
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visa fler...
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Johnson, Theron
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Schulze, Matthia ...
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Schiborn, Catari ...
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Rostgaard-Hansen ...
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Tjønneland, Anne
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Overvad, Kim
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Pérez, María Jos ...
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Crous-Bou, Marta
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Chirlaque, María ...
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Amiano, Pilar
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Ardanaz, Eva
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Watts, Eleanor L ...
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Travis, Ruth C.
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Sacerdote, Carlo ...
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Grioni, Sara
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Masala, Giovanna
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Signoriello, Sim ...
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Tumino, Rosario
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Gram, Inger T.
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Sandanger, Torkj ...
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Sartor, Hanna
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Lundin, Eva
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Idahl, Annika, 1 ...
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Heath, Alicia K.
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Dossus, Laure
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Weiderpass, Elis ...
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Kaaks, Rudolf
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och Klinisk medicin
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och Cancer och onkol ...
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British Journal ...
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Umeå universitet
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Lunds universitet