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  • Malla, SandhyaUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för molekylärbiologi (Medicinska fakulteten) (author)

ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-17
  • John Wiley & Sons,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-191672
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191672URI
  • https://doi.org/10.15252/embr.202153191DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148561992URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The pluripotent state is not solely governed by the action of the core transcription factors OCT4, SOX2, and NANOG, but also by a series of co-transcriptional and post-transcriptional events, including alternative splicing (AS) and the interaction of RNA-binding proteins (RBPs) with defined subpopulations of RNAs. Zinc Finger Protein 207 (ZFP207) is an essential transcription factor for mammalian embryonic development. Here, we employ multiple functional analyses to characterize its role in mouse embryonic stem cells (ESCs). We find that ZFP207 plays a pivotal role in ESC maintenance, and silencing of Zfp207 leads to severe neuroectodermal differentiation defects. In striking contrast to human ESCs, mouse ZFP207 does not transcriptionally regulate neuronal and stem cell-related genes but exerts its effects by controlling AS networks and by acting as an RBP. Our study expands the role of ZFP207 in maintaining ESC identity, and underscores the functional versatility of ZFP207 in regulating neural fate commitment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bhattarai, Devi PrasadUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)depr0160 (author)
  • Groza, PaulaUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)pape8310 (author)
  • Melguizo-Sanchis, DarioUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)dame0026 (author)
  • Atanasoai, IonutKarolinska Institutet (author)
  • Martinez Gamero, CarlosUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)cama0212 (author)
  • Román, Ángel-CarlosDepartment of Biochemistry, Molecular Biology and Genetics, University of Extremadura, Badajoz, Spain (author)
  • Zhu, DandanDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, TX, Houston, United States (author)
  • Lee, Dung-FangDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, TX, Houston, United States; Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, TX, Houston, United States; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, TX, Houston, United States; Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, TX, Houston, United States (author)
  • Kutter, ClaudiaKarolinska Institutet (author)
  • Aguilo, Francesca,PhDUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)frag0008 (author)
  • Umeå universitetWallenberg centrum för molekylär medicin vid Umeå universitet (WCMM) (creator_code:org_t)

Related titles

  • In:EMBO Reports: John Wiley & Sons23:31469-221X1469-3178

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