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Sökning: (WFRF:(Gsur A)) lar1:(umu) > (2022) > Molecular and Patho...

  • Borozan, IvanOntario Institute for Cancer Research, ON, Toronto, Canada (författare)

Molecular and Pathology Features of Colorectal Tumors and Patient Outcomes Are Associated with Fusobacterium nucleatum and Its Subspecies animalis

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • American Association for Cancer Research,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-191737
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191737URI
  • https://doi.org/10.1158/1055-9965.EPI-21-0463DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Fusobacterium nucleatum (F. nucleatum) activates oncogenic signaling pathways and induces inflammation to promote colorectal carcinogenesis.Methods: We characterized F. nucleatum and its subspecies in colorectal tumors and examined associations with tumor characteristics and colorectal cancer-specific survival. We conducted deep sequencing of nusA, nusG, and bacterial 16s rRNA genes in tumors from 1,994 patients with colorectal cancer and assessed associations between F. nucleatum presence and clinical characteristics, colorectal cancer-specific mortality, and somatic mutations.Results: F. nucleatum, which was present in 10.3% of tumors, was detected in a higher proportion of right-sided and advanced-stage tumors, particularly subspecies animalis. Presence of F. nucleatum was associated with higher colorectal cancer-specific mortality (HR, 1.97; P = 0.0004). This association was restricted to nonhypermutated, microsatellite-stable tumors (HR, 2.13; P = 0.0002) and those who received chemotherapy [HR, 1.92; confidence interval (CI), 1.07-3.45; P = 0.029). Only F. nucleatum subspecies animalis, the main subspecies detected (65.8%), was associated with colorectal cancer-specific mortality (HR, 2.16; P = 0.0016), subspecies vincentii and nucleatum were not (HR, 1.07; P = 0.86). Additional adjustment for tumor stage suggests that the effect of F. nucleatum on mortality is partly driven by a stage shift. Presence of F. nucleatum was associated with microsatellite instable tumors, tumors with POLE exonuclease domain mutations, and ERBB3 mutations, and suggestively associated with TP53 mutations.Conclusions: F. nucleatum, and particularly subspecies animalis, was associated with a higher colorectal cancer-specific mortality and specific somatic mutated genes.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zaidi, Syed H.Ontario Institute for Cancer Research, ON, Toronto, Canada (författare)
  • Harrison, Tabitha A.Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States (författare)
  • Phipps, Amanda I.Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States (författare)
  • Zheng, JiayinPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States (författare)
  • Lee, StephenOntario Institute for Cancer Research, ON, Toronto, Canada (författare)
  • Trinh, Quang M.Ontario Institute for Cancer Research, ON, Toronto, Canada (författare)
  • Steinfelder, Robert S.Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States (författare)
  • Adams, JeremyOntario Institute for Cancer Research, ON, Toronto, Canada (författare)
  • Banbury, Barbara L.Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States (författare)
  • Berndt, Sonja I.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
  • Brezina, StefanieInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria (författare)
  • Buchanan, Daniel D.Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, VIC, Parkville, Australia; The University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Familial Cancer Clinic, Genetic Medicine, The Royal Melbourne Hospital, VIC, Parkville, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Parkville, Australia (författare)
  • Bullman, SusanHuman Biology Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
  • Cao, YinDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St Louis, MO, United States; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St Louis, MO, United States (författare)
  • Farris III, Alton B.Pathology and Laboratory Medicine, Emory University, School of Medicine, GA, Atlanta, United States (författare)
  • Figueiredo, Jane C.Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States (författare)
  • Giannakis, MariosDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States (författare)
  • Heisler, Lawrence E.Ontario Institute for Cancer Research, ON, Toronto, Canada (författare)
  • Hopper, John L.The University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia (författare)
  • Lin, YiPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States (författare)
  • Luo, XuemeiOntario Institute for Cancer Research, ON, Toronto, Canada (författare)
  • Nishihara, ReikoDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States (författare)
  • Mardis, Elaine R.The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, OH, Columbus, United States (författare)
  • Papadopoulos, NickolasLudwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, MD, Baltimore, United States (författare)
  • Qu, ConghuiPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States (författare)
  • Reid, Emma E.G.Ontario Institute for Cancer Research, ON, Toronto, Canada (författare)
  • Thibodeau, Stephen N.Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States (författare)
  • Harlid, Sophia,1978-Umeå universitet,Onkologi(Swepub:umu)soha0105 (författare)
  • Um, Caroline Y.Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States (författare)
  • Hsu, LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States; Department of Biostatistics, School of Public Health, University of Washington, WA, Seattle, United States (författare)
  • Gsur, AndreaInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria (författare)
  • Campbell, Peter T.Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States (författare)
  • Gallinger, StevenOntario Institute for Cancer Research, ON, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health, University of Toronto, ON, Toronto, Canada; General Surgery, Surgery and Critical Care Program, University Health Network Toronto General Hospital, University of Toronto, ON, Toronto, Canada (författare)
  • Newcomb, Polly A.Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States (författare)
  • Ogino, ShujiDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Cancer Immunology Program, Dana-Farber/Harvard Cancer Center, MA, Boston, United States; Cancer Epidemiology Program, Dana-Farber/Harvard Cancer Center, MA, Boston, United States (författare)
  • Sun, WeiPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States (författare)
  • Hudson, Thomas J.Ontario Institute for Cancer Research, ON, Toronto, Canada (författare)
  • Ferretti, VincentOntario Institute for Cancer Research, ON, Toronto, Canada; CHU Sainte-Justine Research Center, University of Montreal, QC, Montreal, Canada (författare)
  • Peters, UlrikePublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States (författare)
  • Ontario Institute for Cancer Research, ON, Toronto, CanadaPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Epidemiology, Biomarkers and Prevention: American Association for Cancer Research31:1, s. 210-2201055-99651538-7755

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