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Multiomics and digi...
Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health
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- Marabita, Francesco (författare)
- Karolinska Institutet
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- James, Tojo (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.;Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17165 Stockholm, Sweden.
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- Karhu, Anu (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.
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visa fler...
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- Virtanen, Heidi (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.
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- Kettunen, Kaisa (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; HUS Diagnostic Center, Division of Genetics and Clinical Pharmacology Laboratory of Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.;Univ Helsinki, Div Genet, HUS Diagnost Ctr, Helsinki 00029, Finland.;Univ Helsinki, Clin Pharmacol Lab Genet, Helsinki 00029, Finland.;Helsinki Univ Hosp, Helsinki 00029, Finland.
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- Stenlund, Hans (författare)
- Umeå universitet,Institutionen för fysiologisk botanik,Umeå Univ, Swedish Metabol Ctr, Dept Plant Physiol, Sci Life Lab, S-90187 Umeå, Sweden.,Umea University
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- Boulund, Fredrik (författare)
- Science for Life Laboratory, Center for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumor & Cell Biol, Sci Life Lab, S-17165 Stockholm, Sweden.
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- Hellström, Cecilia (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Science for Life Laboratory, Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden
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- Neiman, Maja, 1983- (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Science for Life Laboratory, Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden
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- Mills, Robert (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.
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- Perheentupa, Teemu (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.
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- Laivuori, Hannele (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Center for Child, Adolescent and Maternal Health Research, Tampere, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.;Helsinki Univ Hosp, Helsinki 00029, Finland.;Univ Helsinki, Med & Clin Genet, Helsinki 00029, Finland.;Tampere Univ Hosp, Dept Obstet & Gynecol, Tampere 33520, Finland.;Tampere Univ, Fac Med & Hlth Technol, Ctr Child Adolescent & Maternal Hlth Res, Tampere 33520, Finland.
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- Helkkula, Pyry (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.
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- Byrne, Myles (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.
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- Jokinen, Ilkka (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.
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- Honko, Harri (författare)
- Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland,Tampere Univ, Fac Med & Hlth Technol, Tampere 33520, Finland.
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- Kallonen, Antti (författare)
- Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland,Tampere Univ, Fac Med & Hlth Technol, Tampere 33520, Finland.
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- Ermes, Miikka (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland,VTT Tech Res Ctr Finland, Espoo 02044, Finland.
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- Similä, Heidi (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland,VTT Tech Res Ctr Finland, Espoo 02044, Finland.
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- Lindholm, Mikko (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland,VTT Tech Res Ctr Finland, Espoo 02044, Finland.
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- Widén, Elisabeth (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.
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- Ripatti, Samuli (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Broad Institute of MIT and Harvard, MA, Cambridge, United States,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.;Univ Helsinki, Fac Med, Publ Hlth, Helsinki 00014, Finland.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
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- Perälä-Heape, Maritta (författare)
- Faculty of Medicine, University of Oulu, Oulu, Finland; Centre for Health and Technology, University of Oulu, Oulu, Finland,Univ Oulu, Fac Med, Oulu 90014, Finland.;Univ Oulu, Ctr Hlth & Technol, Oulu 90220, Finland.
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- Engstrand, Lars (författare)
- Karolinska Institutet
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- Nilsson, Peter (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Science for Life Laboratory, Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden
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- Moritz, Thomas (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology,University of Copenhagen
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- Miettinen, Timo (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.
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- Sallinen, Riitta (författare)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki 00290, Finland.;Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17165 Stockholm, Sweden.
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- Kallioniemi, Olli (författare)
- Karolinska Institutet
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(creator_code:org_t)
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- Cell Press, 2022
- 2022
- Engelska.
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Ingår i: Cell Systems. - : Cell Press. - 2405-4712 .- 2405-4720. ; 13:3, s. 241-255.e7
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- We explored opportunities for personalized and predictive health care by collecting serial clinical measurements, health surveys, genomics, proteomics, autoantibodies, metabolomics, and gut microbiome data from 96 individuals who participated in a data-driven health coaching program over a 16-month period with continuous digital monitoring of activity and sleep. We generated a resource of >20,000 biological samples from this study and a compendium of >53 million primary data points for 558,032 distinct features. Multiomics factor analysis revealed distinct and independent molecular factors linked to obesity, diabetes, liver function, cardiovascular disease, inflammation, immunity, exercise, diet, and hormonal effects. For example, ethinyl estradiol, a common oral contraceptive, produced characteristic molecular and physiological effects, including increased levels of inflammation and impact on thyroid, cortisol levels, and pulse, that were distinct from other sources of variability observed in our study. In total, this work illustrates the value of combining deep molecular and digital monitoring of human health. A record of this paper's transparent peer review process is included in the supplemental information.
Ämnesord
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- lifestyle changes
- multiomics data integration
- P4 medicine
- personalized medicine
- precision health
- precision medicine
- systems medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Marabita, France ...
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James, Tojo
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Karhu, Anu
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Virtanen, Heidi
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Kettunen, Kaisa
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Stenlund, Hans
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visa fler...
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Boulund, Fredrik
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Hellström, Cecil ...
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Neiman, Maja, 19 ...
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Mills, Robert
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Perheentupa, Tee ...
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Laivuori, Hannel ...
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Helkkula, Pyry
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Byrne, Myles
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Jokinen, Ilkka
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Honko, Harri
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Kallonen, Antti
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Ermes, Miikka
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Similä, Heidi
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Lindholm, Mikko
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Widén, Elisabeth
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Ripatti, Samuli
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Perälä-Heape, Ma ...
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Engstrand, Lars
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Nilsson, Peter
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Moritz, Thomas
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Miettinen, Timo
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Sallinen, Riitta
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Kallioniemi, Oll ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Bioinformatik oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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Cell Systems
- Av lärosätet
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Umeå universitet
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Kungliga Tekniska Högskolan
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Karolinska Institutet
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Sveriges Lantbruksuniversitet