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  • Omran, MeisKarolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ, Sweden (author)

Whole-Body MRI Surveillance : Baseline Findings in the Swedish Multicentre Hereditary TP53-Related Cancer Syndrome Study (SWEP53)

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-13
  • MDPI,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-191742
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191742URI
  • https://doi.org/10.3390/cancers14020380DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469187URI
  • https://lup.lub.lu.se/record/0b9ee29a-5966-4a90-aed7-c1c55d49d01dURI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183443URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148888003URI
  • https://gup.ub.gu.se/publication/315698URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Breast Cancer Theme Center (BRECT) at Karolinska Institutet; Karolinska University HospitalKarolinska Institutet; Cancer Society in Stockholm; King Gustaf V Jubilee Fund [ORCID: 0000-0003-1425-5189]; Rare Disease Research Foundation; Stockholm County CouncilStockholm County Council [CAN 2016/775, ORCID: 0000-0002-0705-6440]; Swedish Cancer SocietySwedish Cancer Society [TJ2018-0054]; Swedish Childhood Cancer Fund [SE-221 84, TJ2021-0125]; [SE-416 50]; [ORCID: 0000-0002-0518-983X]; [SE-901 87]; [SE-221 00]; [ORCID: 0000-0003-2967-735X]; [SE-413 45]; [ORCID: 0000-0003-2507-7197]; [SE-405 30]; [SE-171 76]; [SE-171 77]; [ORCID: 0000-0001-8066-5843]; [201052]; [SE-751 85]; [SLL20180046]; [ORCID: 0000-0002-4949-2494]; [SLL500306]
  • A surveillance strategy of the heritable TP53-related cancer syndrome (hTP53rc), commonly referred to as the Li–Fraumeni syndrome (LFS), is studied in a prospective observational nationwide multi-centre study in Sweden (SWEP53). The aim of this sub-study is to evaluate whole-body MRI (WB-MRI) regarding the rate of malignant, indeterminate, and benign imaging findings and the associated further workup generated by the baseline examination. Individuals with hTP53rc were enrolled in a surveillance program including annual whole-body MRI (WB-MRI), brain-MRI, and in female carriers, dedicated breast MRI. A total of 68 adults ≥18 years old have been enrolled to date. Of these, 61 fulfilled the inclusion criteria for the baseline MRI scan. In total, 42 showed a normal scan, while 19 (31%) needed further workup, of whom three individuals (3/19 = 16%) were diagnosed with asymptomatic malignant tumours (thyroid cancer, disseminated upper GI cancer, and liver metastasis from a previous breast cancer). Forty-three participants were women, of whom 21 had performed risk-reducing mastectomy prior to inclusion. The remaining were monitored with breast MRI, and no breast tumours were detected on baseline MRI. WB-MRI has the potential to identify asymptomatic tumours in individuals with hTP53rc syndrome. The challenge is to adequately and efficiently investigate all indeterminate findings. Thus, a multidisciplinary team should be considered in surveillance programs for individuals with hTP53rc syndrome.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Tham, EmmaKarolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ, Sweden (author)
  • Brandberg, YvonneKarolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden (author)
  • Ahlström, Håkan,1953-Uppsala University,Uppsala universitet,Radiologi,Uppsala Univ, Sweden(Swepub:uu)hakanahl (author)
  • Lundgren, Claudia,1966-Uppsala universitet,Experimentell och klinisk onkologi,Uppsala University Hospital,Uppsala Univ Hosp, Sweden(Swepub:uu)clalu702 (author)
  • Paulsson-Karlsson, YlvaDepartment of Immunology, Genetics and Pathology, Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Dept Immunol Genet & Pathol, SE-75185 Uppsala, Sweden. (author)
  • Kuchinskaya, EkaterinaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Klinisk genetik(Swepub:liu)ekaku57 (author)
  • Silander, GustavUmeå University,Umeå universitet,Onkologi,Umeå Univ, Dept Radiat Sci, SE-90187 Umeå, Sweden.(Swepub:umu)gusi0004 (author)
  • Rosén, Anna,1975-Umeå University,Umeå universitet,Onkologi,Umeå Univ, Dept Radiat Sci, SE-90187 Umeå, Sweden.(Swepub:umu)anaron95 (author)
  • Persson, FredrikGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences (author)
  • Leonhardt, Henrik,1963Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Radiol, SE-41345 Gothenburg, Sweden.(Swepub:gu)xleohe (author)
  • Stenmark-Askmalm, MarieDivision of Clinical Genetics, Department of Laboratory Medicine, Office for Medical Services, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Off Med Serv, Dept Lab Med, Div Clin Genet, SE-22885 Lund, Sweden.(Swepub:lu)med-ms43 (author)
  • Berg, JohannaLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Lund Univ, Sweden; Ctr Med & Imaging & Funct, Sweden(Swepub:lu)med-jbe (author)
  • van Westen, DanielleLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Ctr Med & Imaging & Funct, Sweden; Lund Univ, Sweden(Swepub:lu)ront-dva (author)
  • Bajalica-Lagercrantz, SvetlanaKarolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ, Sweden; Karolinska Univ, Sweden (author)
  • Blomqvist, LennartKarolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ, Sweden (author)
  • Karolinska InstituteKarolinska University Hospital (creator_code:org_t)
  • Swedish Clinical TP53 Study Group (SweClinTP53)

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