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Exploring divalent ...
Exploring divalent conjugates of 5-N-acetyl-neuraminic acid as inhibitors of coxsackievirus A24 variant (CVA24v) transduction
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- Johansson, Emil, 1985- (author)
- Umeå universitet,Kemiska institutionen
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- Caraballo, Remi (author)
- Umeå universitet,Kemiska institutionen
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- Zocher, Georg (author)
- Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany
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- Mistry, Nitesh (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Arnberg, Niklas, 1987- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Stehle, Thilo (author)
- Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany; Vanderbilt University, School of Medicine, TN, Nashville, United States
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- Elofsson, Mikael (author)
- Umeå universitet,Kemiska institutionen
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(creator_code:org_t)
- 2022
- 2022
- English.
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In: RSC Advances. - : Royal Society of Chemistry. - 2046-2069. ; 12:4, s. 2319-2331
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Abstract
Subject headings
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- Coxsackievirus A24 variant (CVA24v) is responsible for several outbreaks and two pandemics of the highly contagious eye infection acute hemorrhagic conjunctivitis (AHC). Currently, neither prevention (vaccines) nor treatments (antivirals) are available for combating this disease. CVA24v attaches to cells by binding Neu5Ac-containing glycans on the surface of cells which facilitates entry. Previously, we have demonstrated that pentavalent Neu5Ac conjugates attenuate CVA24v infection of human corneal epithelial (HCE) cells. In this study, we report on the structure-based design of three classes of divalent Neu5Ac conjugates, with varying spacer lengths, and their effect on CVA24v transduction in HCE cells. In relative terms, the most efficient class of divalent Neu5Ac conjugates are more efficient than the pentavalent Neu5Ac conjugates previously reported.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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