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Salivary IgG to SAR...
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals
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- Healy, Katie (author)
- Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Dent Med, Stockholm, Sweden.
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- Pin, Elisa (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Chen, Puran (author)
- Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
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- Söderdahl, Gunnar (author)
- Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
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- Nowak, Piotr (author)
- Karolinska Institutet,Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
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- Mielke, Stephan (author)
- Karolinska Institutet
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- Hansson, Lotta (author)
- Karolinska Institutet
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- Bergman, Peter (author)
- Karolinska Institutet
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- Smith, C.I. Edvard (author)
- Karolinska Institutet
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- Ljungman, Per (author)
- Karolinska Institutet
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- Valentini, Davide (author)
- Karolinska Institutet
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- Blennow, Ola (author)
- Karolinska Institutet
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- Österborg, Anders (author)
- Karolinska Institutet
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- Gabarrini, Giorgio (author)
- Karolinska Institutet
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- Al-Manei, Khaled (author)
- Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Alkharaan, Hassan (author)
- Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden; College of Dentistry, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia
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- Sobkowiak, Michał Jacek (author)
- Karolinska Institutet
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- Yousef, Jamil (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Mravinacová, Sára (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Cuapio, Angelica (author)
- Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
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- Xu, Xinling (author)
- Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
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- Akber, Mira (author)
- Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
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- Loré, Karin (author)
- Karolinska Institutet
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- Hellström, Cecilia (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Muschiol, Sandra (author)
- Karolinska Institutet
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- Bogdanovic, Gordana (author)
- Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
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- Buggert, Marcus (author)
- Karolinska Institutet
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- Ljunggren, Hans-Gustaf (author)
- Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
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- Hober, Sophia, Professor, 1965- (author)
- KTH,Proteinteknologi
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- Nilsson, Peter (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Aleman, Soo (author)
- Karolinska Institutet
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- Sällberg Chen, Margaret (author)
- Karolinska Institutet
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Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden Karolinska Inst, Dept Dent Med, Stockholm, Sweden (creator_code:org_t)
- Cell Press, 2022
- 2022
- English.
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In: Med. - : Cell Press. - 2666-6359 .- 2666-6340. ; 3:2, s. 137-153.e3
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- Background: Immunocompromised individuals are highly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Whether vaccine-induced immunity in these individuals involves oral cavity, a primary site of infection, is presently unknown.Methods: Immunocompromised patients (n = 404) and healthy controls (n = 82) participated in a prospective clinical trial (NCT04780659) encompassing two doses of the mRNA BNT162b2 vaccine. Primary immunodeficiency (PID), secondary immunodeficiencies caused by human immunodeficiency virus (HIV) infection, allogeneic hematopoietic stem cell transplantation (HSCT)/chimeric antigen receptor T cell therapy (CAR-T), solid organ transplantation (SOT), and chronic lymphocytic leukemia (CLL) patients were included. Salivary and serum immunoglobulin G (IgG) reactivities to SARS-CoV-2 spike were measured by multiplex bead-based assays and Elecsys anti-SARS-CoV-2 S assay.Findings: IgG responses to SARS-CoV-2 spike antigens in saliva in HIV and HSCT/CAR-T groups were comparable to those of healthy controls after vaccination. The PID, SOT, and CLL patients had weaker responses, influenced mainly by disease parameters or immunosuppressants. Salivary responses correlated remarkably well with specific IgG titers and the neutralizing capacity in serum. Receiver operating characteristic curve analysis for the predictive power of salivary IgG yielded area under the curve (AUC) = 0.95 and positive predictive value (PPV) = 90.7% for the entire cohort after vaccination.Conclusions: Saliva conveys vaccine responses induced by mRNA BNT162b2. The predictive power of salivary spike IgG makes it highly suitable for screening vulnerable groups for revaccination.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- antibody
- cancer
- COVID-19
- HIV
- immunodeficiency
- saliva
- serum
- Translation to patients
- transplantation
- vaccination
Publication and Content Type
- ref (subject category)
- art (subject category)
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Med
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To the university's database
- By the author/editor
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Healy, Katie
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Pin, Elisa
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Chen, Puran
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Söderdahl, Gunna ...
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Nowak, Piotr
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Mielke, Stephan
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show more...
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Hansson, Lotta
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Bergman, Peter
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Smith, C.I. Edva ...
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Ljungman, Per
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Valentini, David ...
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Blennow, Ola
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Österborg, Ander ...
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Gabarrini, Giorg ...
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Al-Manei, Khaled
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Alkharaan, Hassa ...
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Sobkowiak, Micha ...
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Yousef, Jamil
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Mravinacová, Sár ...
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Cuapio, Angelica
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Xu, Xinling
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Akber, Mira
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Loré, Karin
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Hellström, Cecil ...
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Muschiol, Sandra
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Bogdanovic, Gord ...
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Buggert, Marcus
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Ljunggren, Hans- ...
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Hober, Sophia, P ...
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Nilsson, Peter
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Aleman, Soo
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Sällberg Chen, M ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Med
- By the university
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Umeå University
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Royal Institute of Technology
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Karolinska Institutet