Sökning: WFRF:(Sandström Karl 1973 ) >
Base of tongue squa...
Base of tongue squamous cell carcinomas, outcome depending on treatment strategy and p16 status. A population-based study from the Swedish Head and Neck Cancer Register
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- Högmo, Anders (författare)
- Regional Cancer Centre West, Region Västra Götaland, Gothenburg, Sweden,Reg Vastra Gotaland, Reg Canc Ctr West, Gothenburg, Sweden.,The County of Västra Götaland
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- Holmberg, Erik, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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- Haugen Cange, Hedda (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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- Reizenstein, Johan (författare)
- Department of Oncology, Örebro University Hospital, Örebro, Sweden,Örebro Univ Hosp, Dept Oncol, Örebro, Sweden.
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- Wennerberg, Johan (författare)
- Lund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Head and Neck Cancer Research Group,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden; Univ Hosp Scania, Sweden
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- Beran, Martin (författare)
- Department of ENT and Maxillofacial Surgery, NAL Medical Center Hospital, Trollhättan, Sweden,NAL Med Ctr Hosp, Dept ENT & Maxillofacial Surg, Trollhättan, Sweden.,Norra Älvsborgs Länssjukhus
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- Söderkvist, Karin (författare)
- Umeå universitet,Onkologi,Cancercentre, Umeå University Hospital, Umeå, Sweden,Umeå Univ, Oncol, Dept Radiat Sci, Umeå, Sweden.;Ume 5 Univ Hosp, Cancerctr, Umeå, Sweden.,Norrland University Hospital
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- Hammerlid, Eva, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för öron-, näs- och halssjukdomar,Institute of Clinical Sciences, Department of Otorhinolaryngology
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- Sjödin, Helena (författare)
- Department of Oncology, Theme Cancer, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Dept Oncol, Theme Canc, Stockholm, Sweden.
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- Farnebo, Lovisa, 1973- (författare)
- Linköpings universitet,Linköping University,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Öron- näsa- och halskliniken,Region Östergötland, Hand- och plastikkirurgiska kliniken US
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- Sandström, Karl, 1973- (författare)
- Uppsala University,Uppsala universitet,Öron-, näs- och halssjukdomar,Uppsala Univ, Sweden; Univ Hosp, Sweden
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- Hammarstedt-Nordenvall, Lalle (författare)
- Karolinska Institutet
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- Zborayova, Katarina (författare)
- Umeå University,Umeå universitet,Öron- näs- och halssjukdomar,Umeå University Hospital, Umeå, Sweden,Umeå Univ, Dept Clin Sci, Div Otorhinolaryngol, Umeå, Sweden.;Univ Hosp, Umeå, Sweden.
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- Brun, Eva (författare)
- Lund University,Lunds universitet,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Head and Neck Cancer Research Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Univ Hosp Scania, Sweden; Lund Univ, Sweden
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Regional Cancer Centre West, Region Västra Götaland, Gothenburg, Sweden Reg Vastra Gotaland, Reg Canc Ctr West, Gothenburg, Sweden (creator_code:org_t)
- Taylor & Francis, 2022
- 2022
- Engelska.
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Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 61:4, s. 433-440
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background: The base of tongue squamous cell carcinoma (BOTSCC) is mainly an HPV-related tumor. Radiotherapy (EBRT) ± concomitant chemotherapy (CT) is the backbone of the curatively intended treatment, with brachytherapy (BT) boost as an option. With four different treatment strategies in Sweden, a retrospective study based on the population-based Swedish Head and Neck Cancer Register (SweHNCR) was initiated.Material and methods: Data on tumors, treatment and outcomes in patients with BOTSCC treated between 2008 and 2014 were validated through medical records and updated as needed. Data on p16 status were updated or completed with immunohistochemical analysis of archived tumor material. Tumors were reclassified according to the UICC 8th edition.Results: Treatment was EBRT, EBRT + CT, EBRT + BT or EBRT + CT + BT in 151, 145, 82 and 167 patients respectively (n = 545). A p16 analysis was available in 414 cases; 338 were p16+ and 76 p16−. 5-year overall survival (OS) was 68% (95% CI: 64–72%), with76% and 37% for p16+ patients and p16− patients, respectively. An increase in OS was found with the addition of CT to EBRT for patients with p16+ tumors, stages II–III, but for patients with tumor stage I, p16+ (UICC 8) none of the treatment strategies was superior to EBRT alone.Conclusion: In the present retrospective population-based study of BOTSCC brachytherapy was found to be of no beneficial value in curatively intended treatment. An increase in survival was found for EBRT + CT compared to EBRT alone in patients with advanced cases, stages II and III (UICC 8), but none of the regimes was significantly superior to EBRT as a single treatment modality for stage I (UICC 8), provided there was p16 positivity in the tumor. In the small group of patients with p16− tumors, a poorer prognosis was found, but the small sample size did not allow any comparisons between different treatment strategies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Base of tongue cancer
- brachytherapy
- HPV
- radiotherapy
- survival
- Oncology
- onkologi
- Base of tongue cancer
- brachytherapy
- HPV
- radiotherapy
- survival
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Högmo, Anders
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Holmberg, Erik, ...
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Haugen Cange, He ...
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Reizenstein, Joh ...
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Wennerberg, Joha ...
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Beran, Martin
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Söderkvist, Kari ...
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Hammerlid, Eva, ...
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Sjödin, Helena
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Farnebo, Lovisa, ...
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Sandström, Karl, ...
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Hammarstedt-Nord ...
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Zborayova, Katar ...
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Brun, Eva
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Acta Oncologica
- Av lärosätet
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Umeå universitet
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Uppsala universitet
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Lunds universitet
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Linköpings universitet
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Karolinska Institutet
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Göteborgs universitet