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Antibodies to Porph...
Antibodies to Porphyromonas gingivalis Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction
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- de Vries, Charlotte (författare)
- Karolinska Institutet
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- Ruacho, Guillermo (författare)
- Karolinska Institutet
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- Kindstedt, Elin (författare)
- Umeå universitet,Institutionen för odontologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden; Section for Molecular Periodontology, Department of Odontology, Umeå University, 901 85 Umeå, Sweden; Wallenberg Centre for Molecular Medicine, Umeå University, 901 87 Umeå, Sweden
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- Potempa, Barbara Aleksandra (författare)
- Department of Oral Immunology & Infectious Diseases, University of Louisville, KY, Louisville, United States; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland,Department of Oral Immunology & Infectious Diseases, University of Louisville, Louisville, KY 40202, USA; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow, Poland
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- Potempa, Jan (författare)
- Department of Oral Immunology & Infectious Diseases, University of Louisville, KY, Louisville, United States; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland,Department of Oral Immunology & Infectious Diseases, University of Louisville, Louisville, KY 40202, USA; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow, Poland
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- Klinge, Björn (författare)
- Karolinska Institutet,Malmö universitet,Odontologiska fakulteten (OD),Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
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- Lundberg, Pernilla, 1965- (författare)
- Umeå universitet,Institutionen för odontologi,Section for Molecular Periodontology, Department of Odontology, Umeå University, 901 85 Umeå, Sweden
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- Svenungsson, Elisabet (författare)
- Karolinska Institutet
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- Lundberg, Karin (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-02-15
- 2022
- Engelska.
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Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 11:4
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://mau.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- There is accumulating data suggesting that periodontitis is associated with increased risk of systemic and autoimmune diseases, including cardiovascular disease, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and there is an unmet need to identify these individuals early. With the periodontal bacteria Porphyromonas gingivalis (Pg) as one of the key drivers of periodontitis, we set out to investigate whether antibodies to Pg virulence factor arginine gingipain (Rgp) could serve as a biomarker for periodontitis patients at increased risk of autoimmunity and systemic disease. We measured serum anti-Rgp IgG in three study populations: PAROKRANK (779 individuals with myocardial infarction (MI); 719 controls), where 557 had periodontitis, and 312 were positive for autoantibodies associated with RA/SLE; the PerioGene North pilot (41 periodontitis; 39 controls); and an SLE case/control study (101 SLE; 100 controls). Anti-Rgp IgG levels were increased in severe periodontitis compared to controls (p < 0.0001), in individuals positive for anti-citrullinated protein antibodies (p = 0.04) and anti-dsDNA antibodies (p = 0.035), compared to autoantibody-negative individuals; and in MI patients versus matched controls (p = 0.035). Our data support longitudinal studies addressing the role of anti-Rgp antibodies as biomarkers for periodontitis patients at increased risk of developing autoimmunity linked to RA and SLE, and mechanisms underpinning these associations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Anti-citrullinated protein antibodies
- Anti-double stranded DNA antibodies
- Arginine gingipains
- Autoimmunity
- Myocardial infarction
- Porphyromonas gingivalis
- Rheumatoid arthritis
- Systemic lupus erythematosus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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