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Sökning: WFRF:(Sundström Poromaa Inger 1964 ) > (2020-2024) > White matter micros...

  • Gu, XuanUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för neurovetenskap (författare)

White matter microstructure and volume correlates of premenstrual dysphoric disorder

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-02-23
  • Canadian Medical Association,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-192888
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-192888URI
  • https://doi.org/10.1503/jpn.210143DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470217URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized by psychological and physical symptoms. Differences in white matter have been associated with affective and anxiety disorders, which share some symptoms with PMDD. However, whether white matter structure differs between the brains of individuals with PMDD and healthy controls is not known, nor is its relation to symptom severity.METHODS: We performed tract-based spatial statistics and voxel-based morphometry analyses of diffusion tensor imaging metrics and white matter volume, using 2 neuroimaging data sets (n = 67 and n = 131) and a combined whole-brain and region-of-interest approach. We performed correlation analyses to investigate the relationship between regions with different white matter microstructure and volume and PMDD symptom severity.RESULTS: We found greater fractional anisotropy in the left uncinate fasciculus (d = 0.69) in individuals with PMDD compared to controls. Moreover, the volume of the right uncinate fasciculus was higher in individuals with PMDD compared to controls (d = 0.40). As well, the severity of premenstrual depression was positively correlated with fractional anisotropy in the right superior longitudinal fasciculus (r = 0.35).LIMITATIONS: It is challenging to interpret group differences in diffusion tensor imaging metrics in terms of their underlying biophysical properties. The small size of the control group in the diffusion tensor imaging study may have prevented effects of interest from being detected.CONCLUSION: The findings of the present study provide evidence of differential cerebral white matter structure associated with PMDD and its symptoms.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Dubol, ManonUppsala universitet,Science for Life Laboratory, SciLifeLab(Swepub:uu)mandu832 (författare)
  • Stiernman, LouiseUmeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci, Umeå, Sweden.(Swepub:umu)emlo0014 (författare)
  • Wikström, Johan,1964-Uppsala universitet,Radiologi(Swepub:uu)jwi06759 (författare)
  • Hahn, AndreasDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Austria,Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria. (författare)
  • Lanzenberger, RupertDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Austria,Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria. (författare)
  • Epperson, C. NeillDepartment of Psychiatry, University of Colorado School of Medicine, USA,Univ Colorado, Sch Med, Dept Psychiat, Boulder, CO 80309 USA. (författare)
  • Bixo, MarieUmeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci, Umeå, Sweden.(Swepub:umu)mabi0001 (författare)
  • Sundström Poromaa, Inger,1964-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)inspo702 (författare)
  • Comasco, Erika,1982-Uppsala universitet,Reproduktiv hälsa,Science for Life Laboratory, SciLifeLab(Swepub:uu)erico267 (författare)
  • Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Psychiatry & Neuroscience: Canadian Medical Association47:1, s. E67-E761180-48821488-2434

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