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Progression pattern...
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Tahiru, WidadUmeå universitet,Onkologi
(författare)
Progression patterns in monoclonal gammopathy of undetermined significance and multiple myeloma outcome : a cohort study in 42 patients
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-02-23
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BioMed Central (BMC),2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-193007
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193007URI
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https://doi.org/10.1186/s40164-022-00259-0DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Follow-up of low-risk monoclonal gammopathy of undetermined significance (MGUS) is debated as multiple myeloma (MM) progression risk is low. Worse MM outcome was reported for patients followed for low-risk MGUS, possibly due to less optimal follow-up. However, it is unknown whether progressing low-risk MGUS is associated with aggressive tumor behavior. Understanding these patterns is crucial for MGUS management. Here, we investigated whether progression from low-risk MGUS is associated with worse MM outcome in patients who had no MGUS follow-up before myeloma diagnosis. We retrospectively determined the MGUS status in repeated pre-diagnostic blood samples prospectively collected from 42 myeloma patients in median 11.6 years (first sample) and 3.3 years (repeated sample) before myeloma diagnosis. At first pre-diagnostic blood draw, 12 had low-risk (defined by an immunoglobulin [Ig] G monoclonal [M] spike < 15 g/L and a normal free light-chain ratio) and 30 had MGUS of other risk. MM bone disease was more common in patients with low-risk MGUS at first blood draw (67% vs. 30%, P = 0.041). Median survival since myeloma diagnosis was worse in low-risk than other MGUS at first blood draw (2.3 vs. 7.5 years, P = 0.004). Modest progression was observed between first and repeated blood draw for the majority of low-risk MGUS as 67% remained as low- or low-intermediate-risk MGUS at repeated blood draw. Our study, albeit limited by its small size, indicates that progression from low-risk MGUS is associated with worse MM outcome regardless of MGUS follow-up. Although further investigation is needed, progressing low-risk MGUS could belong to a group of aggressive tumors with progression that is difficult to predict.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Izarra Santamaria, AntonioUmeå universitet,Onkologi
(författare)
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Hultdin, JohanUmeå universitet,Klinisk kemi(Swepub:umu)johu0007
(författare)
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Wu, Wendy Yi-YingUmeå universitet,Onkologi(Swepub:umu)weyi0002
(författare)
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Späth, Florentin,1980-Umeå universitet,Onkologi(Swepub:umu)flsp0001
(författare)
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Umeå universitetOnkologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Experimental Hematology & Oncology: BioMed Central (BMC)11:12162-3619
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