Search: (WFRF:(Mustonen Harri)) >
Single-operator per...
Single-operator peroral pancreatoscopy in the preoperative diagnostics of suspected main duct intraductal papillary mucinous neoplasms : efficacy and novel insights on complications
-
- Vehviläinen, Sini (author)
- Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Program, University of Helsinki, Helsinki, Finland
-
- Fagerström, Niklas (author)
- Karolinska Institutet
-
- Valente, Roberto (author)
- Umeå universitet,Kirurgi,Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden
-
show more...
-
- Seppänen, Hanna (author)
- Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Program, University of Helsinki, Helsinki, Finland
-
- Udd, Marianne (author)
- Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Program, University of Helsinki, Helsinki, Finland
-
- Lindström, Outi (author)
- Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Program, University of Helsinki, Helsinki, Finland
-
- Mustonen, Harri (author)
- Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Program, University of Helsinki, Helsinki, Finland
-
- Swahn, Fredrik (author)
- Department of Surgery, Skåne University Hospital, Lund, Sweden
-
- Arnelo, Urban (author)
- Karolinska Institutet,Umeå universitet,Kirurgi,Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden
-
- Kylänpää, Leena (author)
- Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Program, University of Helsinki, Helsinki, Finland
-
show less...
-
(creator_code:org_t)
- 2022-03-11
- 2022
- English.
-
In: Surgical Endoscopy. - : Springer. - 0930-2794 .- 1432-2218. ; 36, s. 7431-7443
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Background: Distinguishing intraductal papillary mucinous neoplasms (IPMNs) from other pancreatic cystic lesions is essential since IPMNs carry the risk of becoming malignant. Differentiating the main pancreatic duct involving IPMNs (MD-IPMNs) through conventional imaging is deficient. Single-operator peroral pancreatoscopy (SOPP) represents a promising method offering additional information on suspected lesions in the pancreatic main duct (MD). We aimed to determine the role of SOPP in the preoperative diagnostics of suspected MD-IPMNs and identify factors contributing to SOPP-related complications.Materials and Methods: In this primarily retrospective study, SOPPs were performed at three high-volume centers on suspected MD-IPMNs. Primary outcome was the clinical impact of SOPP to subsequent patient care. Additionally, we documented post-SOPP complications and analyzed several assumed patient- and procedure-related risk factors.Results: One hundred and one (101) SOPPs were performed. Subsequent clinical management was affected due to the findings in 86 (85%) cases. Surgery was planned for 29 (29%) patients. A condition other than IPMN explaining MD dilatation was found in 28 (28%) cases. In 35 (35%) cases, follow-up with MRI was continued. Post-SOPP pancreatitis occurred in 20 (20%) patients and one of them was fatal. A decrease in odds of post-SOPP pancreatitis was seen as the MD diameter increases (OR 0.714 for 1.0 mm increase in MD diameter, CI 95% 0.514–0.993, p = 0.045). Furthermore, a correlation between lower MD diameter values and higher severity post-SOPP pancreatitis was seen (TJT = 599, SE = 116.6, z = − 2.31; p = 0.020). History of pancreatitis after endoscopic retrograde cholangiopancreatography was a confirmed risk factor for post-SOPP pancreatitis. Conclusions between complications and other risk factors could not be drawn.Conclusion: SOPP aids clinical decision-making in suspected MD-IPMNs. Risk for post-SOPP pancreatitis is not negligible compared to non-invasive imaging methods. The risk for pancreatitis decreases as the diameter of the MD increases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- IPMN
- Pancreatitis
- Post-ERCP pancreatitis
- Single-operator pancreatoscopy
- Surgery
- kirurgi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Vehviläinen, Sin ...
-
Fagerström, Nikl ...
-
Valente, Roberto
-
Seppänen, Hanna
-
Udd, Marianne
-
Lindström, Outi
-
show more...
-
Mustonen, Harri
-
Swahn, Fredrik
-
Arnelo, Urban
-
Kylänpää, Leena
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Gastroenterology ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Surgery
- Articles in the publication
-
Surgical Endosco ...
- By the university
-
Umeå University
-
Karolinska Institutet