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Development, valida...
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Kim, Hyeong Seok
(author)
Development, validation, and comparison of a nomogram based on radiologic findings for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas : An international multicenter study
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021
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Wiley-Blackwell,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-193275
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193275URI
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https://doi.org/10.1002/jhbp.962DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146377687URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Although we previously proposed a nomogram to predict malignancy in intraductal papillary mucinous neoplasms (IPMN) and validated it in an external cohort, its application is challenging without data on tumor markers. Moreover, existing nomograms have not been compared. This study aimed to develop a nomogram based on radiologic findings and to compare its performance with previously proposed American and Korean/Japanese nomograms.METHODS: We recruited 3708 patients who underwent surgical resection at 31 tertiary institutions in eight countries, and patients with main pancreatic duct >10 mm were excluded. To construct the nomogram, 2606 patients were randomly allocated 1:1 into training and internal validation sets, and area under the receiver operating characteristics curve (AUC) was calculated using 10-fold cross validation by exhaustive search. This nomogram was then validated and compared to the American and Korean/Japanese nomograms using 1102 patients.RESULTS: Among the 2606 patients, 90 had main-duct type, 900 had branch-duct type, and 1616 had mixed-type IPMN. Pathologic results revealed 1628 low-grade dysplasia, 476 high-grade dysplasia, and 502 invasive carcinoma. Location, cyst size, duct dilatation, and mural nodule were selected to construct the nomogram. AUC of this nomogram was higher than the American nomogram (0.691 vs 0.664, P = .014) and comparable with the Korean/Japanese nomogram (0.659 vs 0.653, P = .255).CONCLUSIONS: A novel nomogram based on radiologic findings of IPMN is competitive for predicting risk of malignancy. This nomogram would be clinically helpful in circumstances where tumor markers are not available. The nomogram is freely available at http://statgen.snu.ac.kr/software/nomogramIPMN.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Song, Wookyeong
(author)
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Choo, Wonho
(author)
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Lee, Sungyoung
(author)
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Han, Youngmin
(author)
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Bassi, Claudio
(author)
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Salvia, Roberto
(author)
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Marchegiani, Giovanni
(author)
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Wolfgang, Christopher L.
(author)
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He, Jin
(author)
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Blair, Alex B.
(author)
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Kluger, Michael D.
(author)
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Su, Gloria H.
(author)
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Kim, Song Cheol
(author)
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Song, Ki-Byung
(author)
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Yamamoto, Masakazu
(author)
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Hatori, Takashi
(author)
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Yang, Ching-Yao
(author)
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Yamaue, Hiroki
(author)
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Hirono, Seiko
(author)
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Satoi, Sohei
(author)
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Fujii, Tsutomu
(author)
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Hirano, Satoshi
(author)
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Lou, Wenhui
(author)
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Hashimoto, Yasushi
(author)
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Shimizu, Yasuhiro
(author)
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Del Chiaro, Marco
(author)
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Valente, RobertoPancreatic Surgery Unit, Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute at Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden; Digestive and Liver Disease Unit, Sapienza University of Rome, Rome, Italy(Swepub:umu)rova0033
(author)
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Lohr, MatthiasKarolinska Institutet
(author)
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Choi, Dong Wook
(author)
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Choi, Seong Ho
(author)
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Heo, Jin Seok
(author)
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Motoi, Fuyuhiko
(author)
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Matsumoto, Ippei
(author)
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Lee, Woo Jung
(author)
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Kang, Chang Moo
(author)
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Shyr, Yi-Ming
(author)
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Wang, Shin-E
(author)
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Han, Ho-Seong
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Yoon, Yoo-Seok
(author)
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Besselink, Marc G.
(author)
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van Huijgevoort, Nadine C. M.
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Sho, Masayuki
(author)
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Nagano, Hiroaki
(author)
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Kim, Sang Geol
(author)
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Honda, Goro
(author)
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Yang, Yinmo
(author)
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Yu, Hee Chul
(author)
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Yang, Jae Do
(author)
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Chung, Jun Chul
(author)
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Nagakawa, Yuichi
(author)
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Seo, Hyung Il
(author)
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Lee, Seungyeoun
(author)
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Kim, Hongbeom
(author)
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Kwon, Wooil
(author)
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Park, Taesung
(author)
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Jang, Jin-Young
(author)
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Karolinska InstitutetPancreatic Surgery Unit, Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute at Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden; Digestive and Liver Disease Unit, Sapienza University of Rome, Rome, Italy
(creator_code:org_t)
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In:Journal of hepato-biliary-pancreatic sciences: Wiley-Blackwell1868-69741868-6982
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- By the author/editor
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Kim, Hyeong Seok
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Song, Wookyeong
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Choo, Wonho
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Lee, Sungyoung
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Han, Youngmin
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Bassi, Claudio
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Salvia, Roberto
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Marchegiani, Gio ...
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Wolfgang, Christ ...
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He, Jin
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Blair, Alex B.
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Kluger, Michael ...
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Su, Gloria H.
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Kim, Song Cheol
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Song, Ki-Byung
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Yamamoto, Masaka ...
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Hatori, Takashi
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Yang, Ching-Yao
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Yamaue, Hiroki
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Hirono, Seiko
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Satoi, Sohei
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Fujii, Tsutomu
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Hirano, Satoshi
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Lou, Wenhui
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Hashimoto, Yasus ...
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Shimizu, Yasuhir ...
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Del Chiaro, Marc ...
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Valente, Roberto
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Lohr, Matthias
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Choi, Dong Wook
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Choi, Seong Ho
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Heo, Jin Seok
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Motoi, Fuyuhiko
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Matsumoto, Ippei
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Lee, Woo Jung
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Kang, Chang Moo
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Shyr, Yi-Ming
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Wang, Shin-E
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Han, Ho-Seong
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Yoon, Yoo-Seok
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Besselink, Marc ...
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van Huijgevoort, ...
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Sho, Masayuki
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Nagano, Hiroaki
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Kim, Sang Geol
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Honda, Goro
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Yang, Yinmo
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Yu, Hee Chul
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Yang, Jae Do
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Chung, Jun Chul
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Nagakawa, Yuichi
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Seo, Hyung Il
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Lee, Seungyeoun
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Kim, Hongbeom
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Kwon, Wooil
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Park, Taesung
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Jang, Jin-Young
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Journal of hepat ...
- By the university
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Umeå University
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Karolinska Institutet