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  • Ahola, Reea P.Department of Gastroenterology and Gastrointestinal Surgery, Tampere University Hospital, Tampere University, Tampere, Finland (författare)

Margin clearance greater than 1 mm in nodal-positive pancreatic adenocarcinoma patients : multicentre retrospective analysis

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Oxford University Press,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-228510
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-228510URI
  • https://doi.org/10.1093/bjsopen/zrae076DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:159154976URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: The introduction of the 1 mm cut-off for resection margin according to the Leeds Pathology Protocol has transformed the concept of surgical radicality. Its impact on nodal-positive resected pancreatic ductal adenocarcinoma patients is unclear. The aim of this study was to analyse the effect of margin clearance on survival among resected, nodal-positive pancreatic ductal adenocarcinoma patients whose specimens were analysed according to the Leeds Pathology Protocol.Methods: Data were collected retrospectively from multicentre clinical databases. Resected patients with nodal involvement were included. Overall survival and disease-free survival were analysed according to minimum reported margin clearances of 0, 0.5, 1, and 2 mm. The results are reported separately for patients who had not undergone venous resection and for patients for whom data were available regarding the superior mesenteric vein-facing margin or the vein specimen. The eighth edition of TNM classification by the AJCC was used.Results: The study comprised 290 stage IIB patients and 215 stage III patients without venous resection. The superior mesenteric vein margin analysis comprised 127 stage IIB patients and 198 stage III patients. The different resection margin distances were not associated with overall survival and disease-free survival among patients without venous resection (P > 0.050). Receiving adjuvant therapy was associated with longer overall survival among stage IIB patients (P = 0.034) and stage III patients (P = 0.003) and with longer disease-free survival among stage III patients (P < 0.001).Conclusions: In this study, a margin clearance greater than 1 mm showed no clear effect on overall survival in pancreatic ductal adenocarcinoma patients with nodal involvement, whereas adjuvant therapy was confirmed to be essential to ensure longer overall survival.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zwart, Eline S.Department of Surgery, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, Netherlands (författare)
  • Kurlinkus, BenediktasClinic of Gastroenterology, Nephrourology and Surgery, Faculty of Medicine, Vilnius University, Vilnius, Lithuania (författare)
  • Halimi, AsifUmeå universitet,Kirurgi,Division of Surgery, CLINITECH, Karolinska Institute, Stockholm, Sweden(Swepub:umu)asfhai04 (författare)
  • Yilmaz, Bengi S.Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (författare)
  • Belfiori, GiulioDivision of Pancreatic Surgery, Vita Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy (författare)
  • Roberts, KeithDepartment of Surgery, Birmingham University Hospital National Health Service Foundation Trust, Birmingham, United Kingdom (författare)
  • Pande, RupalyDepartment of Surgery, Birmingham University Hospital National Health Service Foundation Trust, Birmingham, United Kingdom (författare)
  • Al-Saffar, Hasan A.Division of Surgery, CLINITECH, Karolinska Institute, Stockholm, Sweden (författare)
  • Maisonneuve, PatrickDivision of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCCS, Milan, Italy (författare)
  • Ceyhan, Güralp O.HPB Unit, Department of General Surgery, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey (författare)
  • Laukkarinen, JohannaDepartment of Gastroenterology and Gastrointestinal Surgery, Tampere University Hospital, Tampere University, Tampere, Finland; Department of Surgery, Tampere University, Tampere, Finland (författare)
  • Department of Gastroenterology and Gastrointestinal Surgery, Tampere University Hospital, Tampere University, Tampere, FinlandDepartment of Surgery, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, Netherlands (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BJS Open: Oxford University Press8:42474-9842

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  • BJS Open (Sök värdpublikationen i LIBRIS)

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