Matrix Metalloproteinase 8 Expression in a Tumour Predicts a Favourable Prognosis in Pancreatic Ductal Adenocarcinoma

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Kaasinen, MirjamiDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland (författare)

Matrix Metalloproteinase 8 Expression in a Tumour Predicts a Favourable Prognosis in Pancreatic Ductal Adenocarcinoma

Artikel/kapitelEngelska2022

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2022-03-18
MDPI,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-193405
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193405URI
https://doi.org/10.3390/ijms23063314DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:149146420URI

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Språk:engelska
Sammanfattning på:engelska

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Pancreatic ductal adenocarcinoma (PDAC) is a significant cause of cancer-related death globally, and, despite improvements in diagnostics and treatment, survival remains poor. Matrix metalloproteinases (MMPs) are enzymes involved in stroma remodelling in inflammation and cancer. MMP-8 plays a varied prognostic role in cancers of the gastrointestinal tract. We examined the prognostic value of MMP-8 immunoexpression in tumour tissue and the amount of MMP-8-positive polymorphonuclear cells (PMNs) in PDAC and their association with immune responses using C-reactive protein (CRP) as a marker of systemic inflammation. Tumour samples from 141 PDAC patients undergoing surgery in 2002–2011 at the Department of Surgery, Helsinki University Hospital were stained immunohistochemically, for which we evaluated MMP-8 expression in cancer cells and the amount of MMP-8-positive PMNs. We assessed survival using the Kaplan–Meier analysis while uni-and multivariable analyses relied on the Cox proportional hazards model. A negative MMP-8 stain and elevated CRP level predicted a poor prognosis (hazard ratio [HR] = 6.95; 95% confidence interval (CI) 2.69–17.93; p < 0.001) compared to a positive stain and low CRP level (<10 mg/L). The absence of PMNs together with an elevated CRP level also predicted an unfavourable outcome (HR = 3.17; 95% CI 1.60–6.30; p = 0.001). MMP-8 expression in the tumour served as an independent positive prognostic factor (HR = 0.33; 95% CI 0.16–0.68; p = 0.003). Tumour MMP-8 expression and a low CRP level may predict a favourable outcome in PDAC with similar results for MMP-8-positive PMNs and low CRP levels. Tumoural MMP-8 expression represents an independent positive prognostic factor in PDAC.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
C-reactive protein
Matrix metalloproteinase 8
Pancreatic cancer
Polymorphonuclear cell

Biuppslag (personer, institutioner, konferenser, titlar ...)

Hagström, JaanaDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Oral Pathology and Radiology, University of Turku, Turku, Finland; Translational Cancer Medicine Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland (författare)
Mustonen, HarriDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland (författare)
Sorsa, TimoKarolinska Institutet (författare)
Sund, MalinUmeå universitet,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland(Swepub:umu)masu0021 (författare)
Haglund, CajDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland (författare)
Seppänen, HannaDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland (författare)
Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Oral Pathology and Radiology, University of Turku, Turku, Finland; Translational Cancer Medicine Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland (creator_code:org_t)

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Ingår i:International Journal of Molecular Sciences: MDPI23:61661-65961422-0067

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Av författaren/redakt...: Kaasinen, Mirjam ...; Hagström, Jaana; Mustonen, Harri; Sorsa, Timo; Sund, Malin; Haglund, Caj; visa fler...; Seppänen, Hanna; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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Av lärosätet: Umeå universitet; Karolinska Institutet

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