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Human antibody reco...
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Mittler, EvaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
(författare)
Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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American Association for the Advancement of Science,2022
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-193408
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193408URI
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https://doi.org/10.1126/scitranslmed.abl5399DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus (ANDV) and Sin Nombre virus, cause a distinct zoonotic disease, hantavirus cardiopulmonary syndrome (HCPS). Although these infections are severe and have substantial case fatality rates, no FDA-approved hantavirus countermeasures are available. Recent work suggests that monoclonal antibodies may have therapeutic utility. We describe here the isolation of human neutralizing antibodies (nAbs) against tetrameric Gn/Gc glycoprotein spikes from PUUV-experienced donors. We define a dominant class of nAbs recognizing the "capping loop" of Gn that masks the hydrophobic fusion loops in Gc. A subset of nAbs in this class, including ADI-42898, bound Gn/Gc complexes but not Gn alone, strongly suggesting that they recognize a quaternary epitope encompassing both Gn and Gc. ADI-42898 blocked the cell entry of seven HCPS- and HFRS-associated hantaviruses, and single doses of this nAb could protect Syrian hamsters and bank voles challenged with the highly virulent HCPS-causing ANDV and HFRS-causing PUUV, respectively. ADI-42898 is a promising candidate for clinical development as a countermeasure for both HCPS and HFRS, and its mode of Gn/Gc recognition informs the development of broadly protective hantavirus vaccines.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wec, Anna Z.Adimab, LLC, United States
(författare)
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Tynell, JanneUmeå universitet,Institutionen för klinisk mikrobiologi,Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland(Swepub:umu)jaty0002
(författare)
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Guardado-Calvo, PabloStructural Virology Unit, Department of Virology, Institut Pasteur, Paris, France
(författare)
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Wigren, JuliaUmeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)juwi0002
(författare)
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Polanco, Laura C.Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
(författare)
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O'Brien, Cecilia M.U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States; The Geneva Foundation, Tacoma, WA 98402, USA
(författare)
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Slough, Megan M.Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
(författare)
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Abelson, Dafna M.Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA
(författare)
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Serris, AlexandraStructural Virology Unit, Department of Virology, Institut Pasteur, Paris, France
(författare)
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Sakharkar, MrunalAdimab, LLC, United States
(författare)
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Pehau-Arnaudet, GerardStructural Virology Unit, Department of Virology, Institut Pasteur, Paris, France
(författare)
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Bakken, Russell R.U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States
(författare)
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Geoghegan, James C.Adimab, LLC, United States
(författare)
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Jangra, Rohit K.Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
(författare)
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Keller, MarkusInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany
(författare)
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Zeitlin, LarryMapp Biopharmaceutical Inc., San Diego, CA 92121, USA
(författare)
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Vapalahti, OlliZoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland; Veterinary Biosciences, Veterinary Faculty, University of Helsinki, Helsinki, Finland
(författare)
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Ulrich, Rainer G.Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany; Deutsches Zentrum für Infektionsforschung, Partner site Hamburg-Lübeck- Borstel-Riems, Greifswald-Insel Riems, Germany
(författare)
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Bornholdt, Zachary A.Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA
(författare)
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Ahlm, Clas,1956-Umeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)clah0001
(författare)
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Rey, Felix A.Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France
(författare)
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Dye, John M.U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States
(författare)
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Bradfute, Steven B.Center for Global Health, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, United States
(författare)
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Strandin, TomasZoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland
(författare)
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Herbert, Andrew S.U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States; The Geneva Foundation, Tacoma, WA 98402, USA
(författare)
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Forsell, Mattias N. E.Umeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)mafo0173
(författare)
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Walker, Laura M.Adimab, LLC, United States
(författare)
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Chandran, KartikDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
(författare)
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Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USAAdimab, LLC, United States
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Science Translational Medicine: American Association for the Advancement of Science14:6361946-62341946-6242
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Till lärosätets databas
- Av författaren/redakt...
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Mittler, Eva
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Wec, Anna Z.
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Tynell, Janne
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Guardado-Calvo, ...
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Wigren, Julia
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Polanco, Laura C ...
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visa fler...
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O'Brien, Cecilia ...
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Slough, Megan M.
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Abelson, Dafna M ...
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Serris, Alexandr ...
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Sakharkar, Mruna ...
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Pehau-Arnaudet, ...
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Bakken, Russell ...
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Geoghegan, James ...
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Jangra, Rohit K.
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Keller, Markus
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Zeitlin, Larry
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Vapalahti, Olli
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Ulrich, Rainer G ...
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Bornholdt, Zacha ...
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Ahlm, Clas, 1956 ...
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Rey, Felix A.
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Dye, John M.
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Bradfute, Steven ...
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Strandin, Tomas
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Herbert, Andrew ...
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Forsell, Mattias ...
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Walker, Laura M.
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Chandran, Kartik
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