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Sökning: onr:"swepub:oai:DiVA.org:umu-193408" > Human antibody reco...

  • Mittler, EvaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA (författare)

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • American Association for the Advancement of Science,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-193408
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193408URI
  • https://doi.org/10.1126/scitranslmed.abl5399DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus (ANDV) and Sin Nombre virus, cause a distinct zoonotic disease, hantavirus cardiopulmonary syndrome (HCPS). Although these infections are severe and have substantial case fatality rates, no FDA-approved hantavirus countermeasures are available. Recent work suggests that monoclonal antibodies may have therapeutic utility. We describe here the isolation of human neutralizing antibodies (nAbs) against tetrameric Gn/Gc glycoprotein spikes from PUUV-experienced donors. We define a dominant class of nAbs recognizing the "capping loop" of Gn that masks the hydrophobic fusion loops in Gc. A subset of nAbs in this class, including ADI-42898, bound Gn/Gc complexes but not Gn alone, strongly suggesting that they recognize a quaternary epitope encompassing both Gn and Gc. ADI-42898 blocked the cell entry of seven HCPS- and HFRS-associated hantaviruses, and single doses of this nAb could protect Syrian hamsters and bank voles challenged with the highly virulent HCPS-causing ANDV and HFRS-causing PUUV, respectively. ADI-42898 is a promising candidate for clinical development as a countermeasure for both HCPS and HFRS, and its mode of Gn/Gc recognition informs the development of broadly protective hantavirus vaccines.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wec, Anna Z.Adimab, LLC, United States (författare)
  • Tynell, JanneUmeå universitet,Institutionen för klinisk mikrobiologi,Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland(Swepub:umu)jaty0002 (författare)
  • Guardado-Calvo, PabloStructural Virology Unit, Department of Virology, Institut Pasteur, Paris, France (författare)
  • Wigren, JuliaUmeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)juwi0002 (författare)
  • Polanco, Laura C.Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA (författare)
  • O'Brien, Cecilia M.U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States; The Geneva Foundation, Tacoma, WA 98402, USA (författare)
  • Slough, Megan M.Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA (författare)
  • Abelson, Dafna M.Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA (författare)
  • Serris, AlexandraStructural Virology Unit, Department of Virology, Institut Pasteur, Paris, France (författare)
  • Sakharkar, MrunalAdimab, LLC, United States (författare)
  • Pehau-Arnaudet, GerardStructural Virology Unit, Department of Virology, Institut Pasteur, Paris, France (författare)
  • Bakken, Russell R.U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States (författare)
  • Geoghegan, James C.Adimab, LLC, United States (författare)
  • Jangra, Rohit K.Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA (författare)
  • Keller, MarkusInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany (författare)
  • Zeitlin, LarryMapp Biopharmaceutical Inc., San Diego, CA 92121, USA (författare)
  • Vapalahti, OlliZoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland; Veterinary Biosciences, Veterinary Faculty, University of Helsinki, Helsinki, Finland (författare)
  • Ulrich, Rainer G.Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany; Deutsches Zentrum für Infektionsforschung, Partner site Hamburg-Lübeck- Borstel-Riems, Greifswald-Insel Riems, Germany (författare)
  • Bornholdt, Zachary A.Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA (författare)
  • Ahlm, Clas,1956-Umeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)clah0001 (författare)
  • Rey, Felix A.Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France (författare)
  • Dye, John M.U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States (författare)
  • Bradfute, Steven B.Center for Global Health, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, United States (författare)
  • Strandin, TomasZoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland (författare)
  • Herbert, Andrew S.U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States; The Geneva Foundation, Tacoma, WA 98402, USA (författare)
  • Forsell, Mattias N. E.Umeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)mafo0173 (författare)
  • Walker, Laura M.Adimab, LLC, United States (författare)
  • Chandran, KartikDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA (författare)
  • Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USAAdimab, LLC, United States (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Science Translational Medicine: American Association for the Advancement of Science14:6361946-62341946-6242

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