WFRF:(Wänman Johan)
Sökning: WFRF:(Wänman Johan) > A novel radiographi...
- Wänman, JohanUmeå University,Umeå universitet,Ortopedi (författare)
A novel radiographic pattern related to poor prognosis in patients with prostate cancer with metastatic spinal cord compression
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
- Elsevier,2023
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:umu-202101
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-202101URI
- https://doi.org/10.1016/j.euros.2022.12.004DOI
- https://lup.lub.lu.se/record/ef118777-a143-4823-bba5-9d9127046f65URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Background: Prostate cancer spinal bone metastases can have a radiographic profile that mimics multiple myeloma.Objective: To analyse the presence and prognostic value of myeloma-like prostate cancer bone metastases and its relation to known clinical, molecular, and morphological prognostic markers.Design, setting, and participants: A cohort of 110 patients with prostate cancer who underwent surgery for metastatic spinal cord compression (MSCC) was analysed. Spinal bone metastases were classified as myeloma like (n = 20) or non–myeloma like (n = 90) based on magnetic resonance imaging prior to surgery. An immunohistochemical analysis of metastasis samples was performed to assess tumour cell proliferation (percentage of Ki67-positive cells) and the expression levels of prostate-specific antigen (PSA) and androgen receptor (AR). The metastasis subtypes MetA, MetB, and MetC were determined from transcriptomic profiling.Outcome measurements and statistical analysis: Survival curves were compared with the log-rank test. Univariate and multivariate Cox proportional hazard models were used to assess the effects of prognostic variables. Groups were compared using the Mann-Whitney U test for continuous variables and the chi-square test for categorical variables.Results and limitations: Patients with the myeloma-like metastatic pattern had median survival after surgery for MSCC of 1.7 (range 0.1–33) mo, while the median survival period of those with the non–myeloma-like pattern was 13 (range 0–140) mo (p < 0.001). The myeloma-like appearance had an independent prognostic value for the risk of death after MSCC surgery (adjusted hazard ratio 2.4, p = 0.012). Postoperative neurological function was significantly reduced in the myeloma-like group. No association was found between the myeloma-like pattern and morphological markers of known relevance for this patient group: the transcriptomic subtypes MetA, MetB, and MetC; tumour cell proliferation; and AR and PSA expression.Conclusions: A myeloma-like metastatic pattern identifies an important subtype of metastatic prostate cancer associated with poor survival and neurological outcomes after surgery for MSCC.Patient summary: This study describes a novel radiographic pattern of prostate cancer bone metastases and its relation to poor patient prognosis.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Metastatic spinal cord
- compression
- Myeloma-like prostate cancer
- bone metastases
- Prostate cancer
- Metastatic spinal cord compression
- Myeloma-like prostate cancer bone metastases
- Prostate cancer
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Abul-Kasim, KasimLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Radiology Diagnostics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)ront-kab (författare)
- Semenas, JuliusUmeå University,Umeå universitet,Patologi(Swepub:umu)juse0005 (författare)
- Thysell, ElinUmeå University,Umeå universitet,Patologi(Swepub:umu)elnsjn00 (författare)
- Bergh, AndersUmeå University,Umeå universitet,Patologi(Swepub:umu)anbe0010 (författare)
- Wikström, PernillaUmeå University,Umeå universitet,Patologi(Swepub:umu)pewi0001 (författare)
- Crnalic, SeadUmeå University,Umeå universitet,Ortopedi(Swepub:umu)secr0001 (författare)
- Umeå universitetOrtopedi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:European Urology Open Science: Elsevier48, s. 44-532666-16912666-1683
Internetlänk
- https://doi.org/10.1016/j.euros.2022.12.004Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1722979/FULLTEXT01.pdffulltext:print
- http://dx.doi.org/10.1016/j.euros.2022.12.004FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-202101
- https://doi.org/10.1016/j.euros.2022.12.004
- https://lup.lub.lu.se/record/ef118777-a143-4823-bba5-9d9127046f65
Hitta via bibliotek
- European Urology Open Science (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
Hitta mer i SwePub
- Av författaren/redakt...
- Wänman, Johan
- Abul-Kasim, Kasi ...
- Semenas, Julius
- Thysell, Elin
- Bergh, Anders
- Wikström, Pernil ...
- visa fler...
- Crnalic, Sead
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Ortopedi
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Cancer och onkol ...
- Artiklar i publikationen
- European Urology ...
- Av lärosätet
- Umeå universitet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
