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Fungal Endophytes :
Fungal Endophytes : an Accessible Source of Bioactive Compounds with Potential Anticancer Activity
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- Rai, Nilesh (författare)
- Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
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- Gupta, Priyamvada (författare)
- Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
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- Keshri, Priyanka Kumari (författare)
- Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
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- Verma, Ashish (författare)
- Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
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- Mishra, Pradeep (författare)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Kumar, Deepak (författare)
- Department of Botany, Institute of Science, Banaras Hindu University, Varanasi, India
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- Kumar, Ajay (författare)
- Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India
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- Singh, Santosh Kumar (författare)
- Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
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- Gautam, Vibhav (författare)
- Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
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(creator_code:org_t)
- 2022-03-29
- 2022
- Engelska.
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Ingår i: Applied Biochemistry and Biotechnology. - : Springer. - 0273-2289 .- 1559-0291. ; 194, s. 3296-3319
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Endophytes either be bacteria, fungi, or actinomycetes colonize inside the tissue of host plants without showing any immediate negative effects on them. Among numerous natural alternative sources, fungal endophytes produce a wide range of structurally diverse bioactive metabolites including anticancer compounds. Considering the production of bioactive compounds in low quantity, genetic and physicochemical modification of the fungal endophytes is performed for the enhanced production of bioactive compounds. Presently, for the treatment of cancer, chemotherapy is majorly used, but the side effects of chemotherapy are of prime concern in clinical practices. Also, the drug-resistant properties of carcinoma cells, lack of cancer cells-specific medicine, and the side effects of drugs are the biggest obstacles in cancer treatment. The interminable requirement of potential drugs has encouraged researchers to seek alternatives to find novel bioactive compounds, and fungal endophytes seem to be a probable target for the discovery of anticancer drugs. The present review focuses a comprehensive literature on the major fungal endophyte-derived bioactive compounds which are presently been used for the management of cancer, biotic factors influencing the production of bioactive compounds and about the challenges in the field of fungal endophyte research.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Anticancer activity
- Bioactive compound
- Epigenetic modifier
- Fungal endophytes
- Paclitaxel
- Podophyllotoxin
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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