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Evolution of biomarker research in autoimmunity conditions for health professionals and clinical practice

Silverstein, Arthur (author)
Department of the History of Medicine, Johns Hopkins University, MD, Baltimore, United States
Dudaev, Anton (author)
MGUPP, Moscow, Russian Federation
Studneva, Maria (author)
MGUPP, Moscow, Russian Federation; EPMA (European Association for Predictive, Preventive and Personalized Medicine), Brussels, Belgium
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Aitken, John (author)
Otakaro Pathways, Christchurch, New Zealand
Blokh, Sofya (author)
Filatov's Moscow Clinical Pediatric Hospital, Moscow, Russian Federation
Miller, Andrew David (author)
Mendel University and Veterinary Research Institute, Brno, Czech Republic
Tanasova, Sofia (author)
A.I. Evdokimov Moscow State University of Medicine & Dentistry, Moscow, Russian Federation
Rose, Noel (author)
Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Ryals, John (author)
Mathematics Department at Central Georgia Technical College, GA, Warner Robins, United States
Borchers, Christoph (author)
Lady Davis Institute, Segal Cancer Proteomics Centre, McGill University, QC, Montreal, Canada
Nordström, Anders (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
Moiseyakh, Marina (author)
MGUPP, Moscow, Russian Federation
Herrera, Arturo Solís (author)
University of Florida, FL, Gainesville, United States
Skomorohov, Nikita (author)
MGUPP, Moscow, Russian Federation
Marshall, Trevor (author)
University of Adelaide, SA, Adelaide, Australia; Murdoch University, WA, Murdoch, Australia; The Autoimmunity Research Foundation, CA, Thousand Oaks, United States
Wu, Alan (author)
San Francisco General Hospital, CA, San Francisco, United States; UCSF, CA, San Francisco, United States
Cheng, R. Holland (author)
College of Biological Sciences, UC Davis, CA, Davis, United States
Syzko, Ksenia (author)
MGUPP, Moscow, Russian Federation
Cotter, Philip D. (author)
UCSF, CA, San Francisco, United States; ResearchDx and PacificDx, CA, Irvine, United States
Podzyuban, Marianna (author)
MGUPP, Moscow, Russian Federation
Thilly, William (author)
Massachusetts Institute of Technology, MIT, MA, Cambridge, United States
Smith, Paul David (author)
Newberry College, SC, Newberry, United States
Barach, Paul (author)
Wayne State University, IL, Detroit, United States
Bouri, Khaled (author)
Georgetown University, DC, Washington, United States
Schoenfeld, Yehuda (author)
Sheba Medical Center in Tel Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Matsuura, Eiji (author)
Neutron Therapy Research, Center Collaborative Research Center for OMIC & Department of Cell Chemistry, Okayama University, Okayama, Japan
Medvedeva, Veronika (author)
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Shmulevich, Ilya (author)
Institute of Systems Biology (ISB), WA, Seattle, United States
Cheng, Liang (author)
Genitourinary Pathology Service, The Urologic Pathology Fellowship, and Molecular Diagnostics and Molecular Pathology Laboratories, Indiana University School of Medicine, IN, Indianapolis, United States
Seegers, Paul (author)
Stichting PALGA (Pathologisch Anatomisch Landelijk Geautomatiseerd Archief), Houten, Netherlands
Khotskaya, Yekaterina (author)
Clinical Decision Support Management, The Curematch, Inc, CA, San Diego, United States
Flaherty, Keith (author)
Harvard Medical School, MA, Boston, United States; Mass General Cancer Center, Massachusetts General Hospital, MA, Boston, United States
Dooley, Steven (author)
Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
Sorenson, Eric J. (author)
Mayo Clinic, MN, Rochester, United States
Ross, Michael (author)
UCLA Medical Center Obstetrics & Gynecology, CA, Los Angeles, United States
Suchkov, Sergey (author)
MGUPP, Moscow, Russian Federation; EPMA (European Association for Predictive, Preventive and Personalized Medicine), Brussels, Belgium; A.I. Evdokimov Moscow State University of Medicine & Dentistry, Moscow, Russian Federation; ISPM (International Society for Personalized Medicine), Tokyo, Japan; PMC (Personalized Medicine Coalition), DC, Washington, United States; New York Academy of Sciences, NY, New York, United States; Association for Medical Education in Europe (AMEE), Dundee, United Kingdom
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 (creator_code:org_t)
Elsevier, 2022
2022
English.
In: Precision medicine. - : Elsevier. - 9780323997843 ; , s. 219-276
  • Book chapter (peer-reviewed)
Abstract Subject headings
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  • Medical abzymology has made a great contribution to the development of general autoimmunity theory: it has put the autoantibodies (Ab) as the key brick of the theory to the level of physiological functionality by providing such Ab with the ability to catalyze and mediate direct and independent cytotoxic effect on cellular and molecular targets. Natural catalytic autoantibodies (abzymes) while being a pool of canonical Abs and possessing catalytic activity belong to the new group of physiologically active substances whose features and properties are evolutionary consolidated in one functionally active biomolecule. Therefore, further studies on Ab-mediated autoAg degradation and other targeted Ab-mediated proteolysis may provide biomarkers of newer generations and thus a supplementary tool for assessing the disease progression and predicting disability of the patients and persons at risks. This chapter is a summary of current knowledge and prognostic perspectives toward catalytic Abs in autoimmunity and thus some autoimmune clinical cases, their role in pathogenesis, and the exploitation of both whole molecules and their constituent parts in developing highly effective targeted drugs of the future to come, and thus the therapeutic protocols being individualized.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Keyword

Biomarker
Multimarker-based companion diagnostics
Multiple sclerosis
Next-generation biomarker
Personalized and precision medicine
Protein microarrays
Rheumatoid arthritis
Targeted therapy
Western blotting

Publication and Content Type

ref (subject category)
kap (subject category)

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