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  • Silverstein, ArthurDepartment of the History of Medicine, Johns Hopkins University, MD, Baltimore, United States (författare)

Evolution of biomarker research in autoimmunity conditions for health professionals and clinical practice

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-194436
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194436URI
  • https://doi.org/10.1016/bs.pmbts.2022.02.004DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:kap swepub-publicationtype

Anmärkningar

  • Medical abzymology has made a great contribution to the development of general autoimmunity theory: it has put the autoantibodies (Ab) as the key brick of the theory to the level of physiological functionality by providing such Ab with the ability to catalyze and mediate direct and independent cytotoxic effect on cellular and molecular targets. Natural catalytic autoantibodies (abzymes) while being a pool of canonical Abs and possessing catalytic activity belong to the new group of physiologically active substances whose features and properties are evolutionary consolidated in one functionally active biomolecule. Therefore, further studies on Ab-mediated autoAg degradation and other targeted Ab-mediated proteolysis may provide biomarkers of newer generations and thus a supplementary tool for assessing the disease progression and predicting disability of the patients and persons at risks. This chapter is a summary of current knowledge and prognostic perspectives toward catalytic Abs in autoimmunity and thus some autoimmune clinical cases, their role in pathogenesis, and the exploitation of both whole molecules and their constituent parts in developing highly effective targeted drugs of the future to come, and thus the therapeutic protocols being individualized.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Dudaev, AntonMGUPP, Moscow, Russian Federation (författare)
  • Studneva, MariaMGUPP, Moscow, Russian Federation; EPMA (European Association for Predictive, Preventive and Personalized Medicine), Brussels, Belgium (författare)
  • Aitken, JohnOtakaro Pathways, Christchurch, New Zealand (författare)
  • Blokh, SofyaFilatov's Moscow Clinical Pediatric Hospital, Moscow, Russian Federation (författare)
  • Miller, Andrew DavidMendel University and Veterinary Research Institute, Brno, Czech Republic (författare)
  • Tanasova, SofiaA.I. Evdokimov Moscow State University of Medicine & Dentistry, Moscow, Russian Federation (författare)
  • Rose, NoelJohns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States (författare)
  • Ryals, JohnMathematics Department at Central Georgia Technical College, GA, Warner Robins, United States (författare)
  • Borchers, ChristophLady Davis Institute, Segal Cancer Proteomics Centre, McGill University, QC, Montreal, Canada (författare)
  • Nordström, AndersUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)anno0185 (författare)
  • Moiseyakh, MarinaMGUPP, Moscow, Russian Federation (författare)
  • Herrera, Arturo SolísUniversity of Florida, FL, Gainesville, United States (författare)
  • Skomorohov, NikitaMGUPP, Moscow, Russian Federation (författare)
  • Marshall, TrevorUniversity of Adelaide, SA, Adelaide, Australia; Murdoch University, WA, Murdoch, Australia; The Autoimmunity Research Foundation, CA, Thousand Oaks, United States (författare)
  • Wu, AlanSan Francisco General Hospital, CA, San Francisco, United States; UCSF, CA, San Francisco, United States (författare)
  • Cheng, R. HollandCollege of Biological Sciences, UC Davis, CA, Davis, United States (författare)
  • Syzko, KseniaMGUPP, Moscow, Russian Federation (författare)
  • Cotter, Philip D.UCSF, CA, San Francisco, United States; ResearchDx and PacificDx, CA, Irvine, United States (författare)
  • Podzyuban, MariannaMGUPP, Moscow, Russian Federation (författare)
  • Thilly, WilliamMassachusetts Institute of Technology, MIT, MA, Cambridge, United States (författare)
  • Smith, Paul DavidNewberry College, SC, Newberry, United States (författare)
  • Barach, PaulWayne State University, IL, Detroit, United States (författare)
  • Bouri, KhaledGeorgetown University, DC, Washington, United States (författare)
  • Schoenfeld, YehudaSheba Medical Center in Tel Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel (författare)
  • Matsuura, EijiNeutron Therapy Research, Center Collaborative Research Center for OMIC & Department of Cell Chemistry, Okayama University, Okayama, Japan (författare)
  • Medvedeva, VeronikaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation (författare)
  • Shmulevich, IlyaInstitute of Systems Biology (ISB), WA, Seattle, United States (författare)
  • Cheng, LiangGenitourinary Pathology Service, The Urologic Pathology Fellowship, and Molecular Diagnostics and Molecular Pathology Laboratories, Indiana University School of Medicine, IN, Indianapolis, United States (författare)
  • Seegers, PaulStichting PALGA (Pathologisch Anatomisch Landelijk Geautomatiseerd Archief), Houten, Netherlands (författare)
  • Khotskaya, YekaterinaClinical Decision Support Management, The Curematch, Inc, CA, San Diego, United States (författare)
  • Flaherty, KeithHarvard Medical School, MA, Boston, United States; Mass General Cancer Center, Massachusetts General Hospital, MA, Boston, United States (författare)
  • Dooley, StevenMedical Faculty Mannheim, Heidelberg University, Heidelberg, Germany (författare)
  • Sorenson, Eric J.Mayo Clinic, MN, Rochester, United States (författare)
  • Ross, MichaelUCLA Medical Center Obstetrics & Gynecology, CA, Los Angeles, United States (författare)
  • Suchkov, SergeyMGUPP, Moscow, Russian Federation; EPMA (European Association for Predictive, Preventive and Personalized Medicine), Brussels, Belgium; A.I. Evdokimov Moscow State University of Medicine & Dentistry, Moscow, Russian Federation; ISPM (International Society for Personalized Medicine), Tokyo, Japan; PMC (Personalized Medicine Coalition), DC, Washington, United States; New York Academy of Sciences, NY, New York, United States; Association for Medical Education in Europe (AMEE), Dundee, United Kingdom (författare)
  • Department of the History of Medicine, Johns Hopkins University, MD, Baltimore, United StatesMGUPP, Moscow, Russian Federation (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Precision medicine: Elsevier, s. 219-2769780323997843

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