Antenatal corticosteroid treatment and placental pathology, with a focus on villous maturation

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MARC

Um-Bergström, MirandaDepartment of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden; Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden (author)

Antenatal corticosteroid treatment and placental pathology, with a focus on villous maturation

Article/chapterEnglish2017

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2017-10-26
Wiley-Blackwell,2017
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LIBRIS-ID:oai:DiVA.org:umu-195265
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-195265URI
https://doi.org/10.1111/aogs.13242DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:137298384URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Introduction: Mothers at risk of preterm birth are treated with antenatal corticosteroids, which have advantageous effects for prematurely born infants. Accelerated villous maturation in the placenta is also associated with improved perinatal outcome. The primary aim of this study was to examine the association between antenatal corticosteroids and accelerated villous maturation. The secondary aim was to study associations with other placental pathologies.Material and methods: A retrospective cohort study including 105 women who had (n = 75) or had not (n = 30) been treated with antenatal corticosteroids. The women gave birth between 22+0 and 26+6 weeks of gestation in Stockholm County between 1 April 2004 and 31 March 2007. A pathologist blinded to all clinical data except gestational age examined the placental slides to identify pathology parameters. The outcomes were correlated with antenatal corticosteroid treatment, and confounding factors were adjusted using logistic regression.Results: Accelerated villous maturation was significantly higher in the group treated with corticosteroids (odds ratio 16, 95% CI 2.4–690, p = 0.0005). After adjustment for gestational age and preeclampsia, the difference remained significant (odds ratio 8.9, 95% CI 1.2–389, p = 0.021). No significant associations were found regarding the secondary outcome variables, after adjusting for possible confounders.Conclusions: Antenatal corticosteroid treatment before preterm birth is associated with accelerated villous maturation. This could be one of the pathways by which corticosteroids are beneficial for preterm infants.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
Accelerated villous maturation
corticosteroids
placenta
placental pathology
pregnancy
preterm birth

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Papadogiannakis, NikosKarolinska Institutet (author)
Westgren, MagnusKarolinska Institutet (author)
Vinnars, Marie-ThereseKarolinska Institutet(Swepub:umu)mavi0140 (author)
Karolinska InstitutetDepartment of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden; Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden (creator_code:org_t)

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In:Acta Obstetricia et Gynecologica Scandinavica: Wiley-Blackwell97:1, s. 74-810001-63491600-0412

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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