Comparison of rhinitis treatments using MASK-air® data and considering the minimal important difference

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Sousa-Pinto, BernardoMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE – Health Research Network, University of Porto, Porto, Portugal (författare)

Comparison of rhinitis treatments using MASK-air® data and considering the minimal important difference

Artikel/kapitelEngelska2022

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2022-06-13
John Wiley & Sons,2022
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LIBRIS-ID:oai:DiVA.org:umu-196830
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-196830URI
https://doi.org/10.1111/all.15371DOI

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Språk:engelska
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Background: Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., “real-world data”). We aimed to compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogue scales (VASs) on allergy symptom control considering the minimal important difference (MID) and (iv) the effect of AIT.Methods: We assessed the MASK-air® app data (May 2015–December 2020) by users self-reporting AR (16–90 years). We compared eight AR medication schemes on reported VAS of allergy symptoms, clustering data by the patient and controlling for confounding factors. We compared (i) allergy symptoms between patients with and without AIT and (ii) different drug classes used in co-medication.Results: We analysed 269,837 days from 10,860 users. Most days (52.7%) involved medication use. Median VAS levels were significantly higher in co-medication than in monotherapy (including the fixed combination azelastine-fluticasone) schemes. In adjusted models, azelastine-fluticasone was associated with lower average VAS global allergy symptoms than all other medication schemes, while the contrary was observed for oral corticosteroids. AIT was associated with a decrease in allergy symptoms in some medication schemes. A difference larger than the MID compared to no treatment was observed for oral steroids. Azelastine-fluticasone was the drug class with the lowest chance of being used in co-medication (adjusted OR = 0.75; 95% CI = 0.71–0.80).Conclusion: Median VAS levels were higher in co-medication than in monotherapy. Patients with more severe symptoms report a higher treatment, which is currently not reflected in guidelines.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
allergen immunotherapy
allergic rhinitis
co-medication
multivariable mixed-effects model
real-world data

Biuppslag (personer, institutioner, konferenser, titlar ...)

Schünemann, Holger J.Department of Health Research Methods, Evidence, and Impact & Department of Medicine, McMaster University, ON, Hamilton, Canada (författare)
Sá-Sousa, AnaMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE – Health Research Network, University of Porto, Porto, Portugal (författare)
Vieira, Rafael JoséMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE – Health Research Network, University of Porto, Porto, Portugal (författare)
Amaral, RitaMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE – Health Research Network, University of Porto, Porto, Portugal (författare)
Anto, Josep M.ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain (författare)
Klimek, LudgerDepartment of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, and Center for Rhinology and Allergology, Wiesbaden, Germany (författare)
Czarlewski, WienczyslawaMedical Consulting Czarlewski, Levallois, France (författare)
Mullol, JoaquimRhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain (författare)
Pfaar, OliverDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany (författare)
Bedbrook, AnnaARIA, Montpellier, France (författare)
Brussino, LuisaDepartment of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino & Mauriziano Hospital, Torino, Italy (författare)
Kvedariene, VioletaInstitute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University and Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania (författare)
Larenas-Linnemann, DesiréeCenter of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico (författare)
Okamoto, YoshitakaDepartment of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan (författare)
Ventura, Maria TeresaUniversity of Bari Medical School, Unit of Geriatric Immunoallergology, Bari, Italy (författare)
Agache, IoanaTransylvania University Brasov, Brasov, Romania (författare)
Ansotegui, Ignacio J.Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain (författare)
Bergmann, Karl C.Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany (författare)
Bosnic-Anticevich, SinthiaQuality Use of Respiratory Medicine Group, Woolcock Institute of Medical Research, The University of Sydney, and Sydney Local Health District, NSW, Sydney, Australia (författare)
Brozek, JanDepartment of Health Research Methods, Evidence, and Impact & Department of Medicine, McMaster University, ON, Hamilton, Canada (författare)
Canonica, G. WalterDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy (författare)
Cardona, VictoriaAllergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL Research Network, Barcelona, Spain (författare)
Carreiro-Martins, PedroServiço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal; NOVA Medical School/Comprehensive Health Research Centre (CHRC), Lisbon, Portugal (författare)
Casale, ThomasDivision of Allergy/Immunology, University of South Florida, FL, Tampa, United States (författare)
Cecchi, LorenzoSOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy (författare)
Chivato, TomasSchool of Medicine, University CEU San Pablo, Madrid, Spain (författare)
Chu, Derek K.Department of Medicine and Health Research Methods, Evidence & Impact, McMaster University, ON, Hamilton, Canada (författare)
Cingi, CemalENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey (författare)
Costa, Elísio M.UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal (författare)
Cruz, Alvaro A.Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Brazil (författare)
Del Giacco, StefanoDepartment of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy (författare)
Devillier, PhilippeVIM Suresnes, UMR_0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France (författare)
Eklund, PatrikUmeå universitet,Institutionen för datavetenskap(Swepub:umu)paek0001 (författare)
Fokkens, Wytske J.Department of Otorhinolaryngology, Amsterdam University Medical Centres, Location AMC, Amsterdam, Netherlands (författare)
Gemicioglu, BilunDepartment of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey (författare)
Haahtela, TariSkin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland (författare)
Ivancevich, Juan CarlosServicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina (författare)
Ispayeva, ZhanatPresident of Kazakhstan Association of Allergology and Clinical Immunology, Department of Allergology and Clinical Immunology of the Kazakh National Medical University, Almaty, Kazakhstan (författare)
Jutel, MarekDepartment of Clinical Immunology, Wrocław Medical University, and ALL-MED Medical Research Institute, Wroclaw, Poland (författare)
Kuna, PiotrDivision of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland (författare)
Kaidashev, IgorPoltava State Medical University, Poltava, Ukraine (författare)
Khaitov, MusaNational Research Center, Institute of Immunology, Federal Medicobiological Agency, Laboratory of Molecular Immunology, Moscow, Russia and Pirogov Russian National Research Medical University, Moscow, Russian Federation (författare)
Kraxner, HelgaDepartment of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary (författare)
Laune, DanielKYomed INNOV, Montpellier, France (författare)
Lipworth, BrianScottish Centre for Respiratory Research, Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, United Kingdom (författare)
Louis, RenaudDepartment of Pulmonary Medicine, CHU Sart-Tilman, and GIGA I3 Research Group, Liege, Belgium (författare)
Makris, MichaelAllergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece (författare)
Monti, RiccardoDepartment of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy (författare)
Morais-Almeida, MarioAllergy Center, CUF Descobertas Hospital, Lisbon, Portugal (författare)
Mösges, RalphIMSB, Medical Faculty, University at Cologne, and ClinCompetence Cologne GmbH, Cologne, Germany (författare)
Niedoszytko, MarekDepartment of Allergology, Medical University of Gdańsk, Gdansk, Poland (författare)
Papadopoulos, Nikolaos G.Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece (författare)
Patella, VincenzoDivision of Allergy and Clinical Immunology, Department of Medicine, Agency of Health ASL Salerno, "Santa Maria della Speranza" Hospital, Battipaglia, Italy (författare)
Pham-Thi, NhânEcole Polytechnique Palaiseau, IRBA (Institut de Recherche bio-Médicale des Armées), Bretigny, France (författare)
Regateiro, Frederico S.Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra and Institute of Immunology, Faculty of Medicine, University of Coimbra, and Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal (författare)
Reitsma, SietzeDepartment of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, Netherlands (författare)
Rouadi, Philip W.Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon; ENT Department, Dar Al Shifa Hospital- Salmiya, Salmiya, Kuwait (författare)
Samolinski, BoleslawDepartment of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland (författare)
Sheikh, AzizUsher Institute, The University of Edinburgh, Edinburgh, United Kingdom (författare)
Sova, MilanDepartment of Pulmonary Medicine and Tuberculosis, University Hospital Brno, Brno, Czech Republic (författare)
Todo-Bom, AnaImunoalergologia, Centro Hospitalar Universitário de Coimbra and Faculty of Medicine, University of Coimbra, Coimbra, Portugal (författare)
Taborda-Barata, LuisFaculty of Health Sciences, University of Beira Interior, Covilhã, Portugal; UBIAir - Clinical & Experimental Lung Centre, University of Beira Interior, Covilhã, Portugal; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal (författare)
Toppila-Salmi, SannaSkin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland (författare)
Sastre, JoaquinFundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid, Madrid, Spain (författare)
Tsiligianni, IoannaHealth Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Greece and International Primary Care Respiratory Group IPCRG, Aberdeen, United Kingdom (författare)
Valiulis, ArunasInstitute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania (författare)
Vandenplas, OlivierDepartment of Chest Medicine, Centre Hospitalier Universitaire UCL Namur, Université Catholique de Louvain, Yvoir, Belgium (författare)
Wallace, DanaNova Southeastern University, FL, Fort Lauderdale, United States (författare)
Waserman, SusanDepartment of Medicine, Clinical Immunology and Allergy, McMaster University, ON, Hamilton, Canada (författare)
Yorgancioglu, ArzuCelal Bayar University, Department of Pulmonology, Manisa, Turkey (författare)
Zidarn, MihaelaUniversity Clinic of Respiratory and Allergic Diseases, Golnick, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia (författare)
Zuberbier, TorstenInstitute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany (författare)
Fonseca, Joao A.MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE – Health Research Network, University of Porto, Porto, Portugal (författare)
Bousquet, JeanInstitute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany; University Hospital Montpellier, Montpellier, France (författare)
MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE – Health Research Network, University of Porto, Porto, PortugalDepartment of Health Research Methods, Evidence, and Impact & Department of Medicine, McMaster University, ON, Hamilton, Canada (creator_code:org_t)

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Ingår i:Allergy. European Journal of Allergy and Clinical Immunology: John Wiley & Sons77:10, s. 3002-30140105-45381398-9995

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Av författaren/redakt...: Sousa-Pinto, Ber ...; Schünemann, Holg ...; Sá-Sousa, Ana; Vieira, Rafael J ...; Amaral, Rita; Anto, Josep M.; visa fler...; Klimek, Ludger; Czarlewski, Wien ...; Mullol, Joaquim; Pfaar, Oliver; Bedbrook, Anna; Brussino, Luisa; Kvedariene, Viol ...; Larenas-Linneman ...; Okamoto, Yoshita ...; Ventura, Maria T ...; Agache, Ioana; Ansotegui, Ignac ...; Bergmann, Karl C ...; Bosnic-Anticevic ...; Brozek, Jan; Canonica, G. Wal ...; Cardona, Victori ...; Carreiro-Martins ...; Casale, Thomas; Cecchi, Lorenzo; Chivato, Tomas; Chu, Derek K.; Cingi, Cemal; Costa, Elísio M.; Cruz, Alvaro A.; Del Giacco, Stef ...; Devillier, Phili ...; Eklund, Patrik; Fokkens, Wytske ...; Gemicioglu, Bilu ...; Haahtela, Tari; Ivancevich, Juan ...; Ispayeva, Zhanat; Jutel, Marek; Kuna, Piotr; Kaidashev, Igor; Khaitov, Musa; Kraxner, Helga; Laune, Daniel; Lipworth, Brian; Louis, Renaud; Makris, Michael; Monti, Riccardo; Morais-Almeida, ...; Mösges, Ralph; Niedoszytko, Mar ...; Papadopoulos, Ni ...; Patella, Vincenz ...; Pham-Thi, Nhân; Regateiro, Frede ...; Reitsma, Sietze; Rouadi, Philip W ...; Samolinski, Bole ...; Sheikh, Aziz; Sova, Milan; Todo-Bom, Ana; Taborda-Barata, ...; Toppila-Salmi, S ...; Sastre, Joaquin; Tsiligianni, Ioa ...; Valiulis, Arunas; Vandenplas, Oliv ...; Wallace, Dana; Waserman, Susan; Yorgancioglu, Ar ...; Zidarn, Mihaela; Zuberbier, Torst ...; Fonseca, Joao A.; Bousquet, Jean; visa färre...

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