SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Mikami Kazuya)
 

Sökning: WFRF:(Mikami Kazuya) > (2022) > Circulating free te...

  • Watts, Eleanor L.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England (författare)

Circulating free testosterone and risk of aggressive prostate cancer : Prospective and Mendelian randomisation analyses in international consortia

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-06-07
  • John Wiley & Sons,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-198044
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198044URI
  • https://doi.org/10.1002/ijc.34116DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485999URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Further, the association of genetically predicted testosterone with aggressive disease is not known. We investigated the associations of calculated free and measured total testosterone and sex hormone-binding globulin (SHBG) with aggressive, overall and early-onset prostate cancer. In blood-based analyses, odds ratios (OR) and 95% confidence intervals (CI) for prostate cancer were estimated using conditional logistic regression from prospective analysis of biomarker concentrations in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group (up to 25 studies, 14 944 cases and 36 752 controls, including 1870 aggressive prostate cancers). In Mendelian randomisation (MR) analyses, using instruments identified using UK Biobank (up to 194 453 men) and outcome data from PRACTICAL (up to 79 148 cases and 61 106 controls, including 15 167 aggressive cancers), ORs were estimated using the inverse-variance weighted method. Free testosterone was associated with aggressive disease in MR analyses (OR per 1 SD = 1.23, 95% CI = 1.08-1.40). In blood-based analyses there was no association with aggressive disease overall, but there was heterogeneity by age at blood collection (OR for men aged <60 years 1.14, CI = 1.02-1.28; Phet =.0003: inverse association for older ages). Associations for free testosterone were positive for overall prostate cancer (MR: 1.20, 1.08-1.34; blood-based: 1.03, 1.01-1.05) and early-onset prostate cancer (MR: 1.37, 1.09-1.73; blood-based: 1.08, 0.98-1.19). SHBG and total testosterone were inversely associated with overall prostate cancer in blood-based analyses, with null associations in MR analysis. Our results support free testosterone, rather than total testosterone, in the development of prostate cancer, including aggressive subgroups.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Perez-Cornago, AuroraCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England (författare)
  • Fensom, Georgina K.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England (författare)
  • Smith-Byrne, KarlGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France,Int Agcy Res Canc, Genom Epidemiol Branch, Lyon, France (författare)
  • Noor, UrwahCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England (författare)
  • Andrews, Colm D.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England (författare)
  • Gunter, Marc J.Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France,Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France (författare)
  • Holmes, Michael V.Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom,Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford, England.;Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England (författare)
  • Martin, Richard M.Department of Population Health Sciences, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and Weston NHS Foundation Trust and the University of Bristol, Bristol, United Kingdom,Univ Bristol, Dept Populat Hlth Sci, Populat Hlth Sci, Bristol, Avon, England.;Univ Bristol, MRC Integrat Epidemiol Unit IEU, Populat Hlth Sci, Bristol Med Sch, Bristol, Avon, England.;Univ Hosp Bristol NHS Fdn Trust, Natl Inst Hlth Res NIHR, Bristol Biomed Res Ctr, Bristol, Avon, England.;Weston NHS Fdn Trust, Bristol, Avon, England.;Univ Bristol, Bristol, Avon, England (författare)
  • Tsilidis, Konstantinos K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece,Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England.;Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece (författare)
  • Albanes, DemetriusDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA (författare)
  • Barricarte, AurelioNavarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain,Navarra Publ Hlth Inst, Pamplona, Spain.;Navarra Inst Hlth Res IdiSNA, Pamplona, Spain.;CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain (författare)
  • Bueno-de-Mesquita, BasCentre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Netherlands,Natl Inst Publ Hlth & Environm RIVM, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands (författare)
  • Chen, ChuProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States; Department of Otolaryngology: Head and Neck Surgery, School of Medicine, University of Washington, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA.;Univ Washington, Sch Med, Dept Otolaryngol Head & Neck Surg, Seattle, WA USA,Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England (författare)
  • Cohn, Barbara A.Child Health and Development Studies, Public Health Institute, CA, Berkeley, United States,Publ Hlth Inst, Child Hlth & Dev Studies, Berkeley, CA USA (författare)
  • Dimou, Niki L.Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France,Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France (författare)
  • Ferrucci, LuigiNational Institute on Aging, MD, Baltimore, United States,NIA, Baltimore, MD 21224 USA (författare)
  • Flicker, LeonMedical School, University of Western Australia, WA, Perth, Australia; Western Australian Centre for Health and Ageing, University of Western Australia, WA, Perth, Australia,Univ Western Australia, Med Sch, Perth, WA, Australia.;Univ Western Australia, Western Australian Ctr Hlth & Ageing, Perth, WA, Australia (författare)
  • Freedman, Neal D.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA (författare)
  • Giles, Graham G.Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Melbourne, Australia,Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Monash Hlth, Precis Med, Melbourne, Vic, Australia (författare)
  • Giovannucci, Edward L.Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA (författare)
  • Goodman, Gary E.Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA (författare)
  • Haiman, Christopher A.Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, CA, Los Angeles, United States,Univ Southern Calif, Ctr Genet Epidemiol, Dept Prevent Med, Keck Sch Med,Norris Comprehens Canc Ctr, Los Angeles, CA USA (författare)
  • Hankey, Graeme J.Medical School, University of Western Australia, WA, Perth, Australia,Univ Western Australia, Med Sch, Perth, WA, Australia (författare)
  • Huang, JiaqiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Hunan, Changsha, China,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.;Cent South Univ, Natl Clin Res Ctr Metab Dis, Key Lab Diabet Immunol, Minist Educ,Xiangya Hosp 2, Changsha, Hunan, Peoples R China.;Cent South Univ, Xiangya Hosp 2, Dept Metab & Endocrinol, Changsha, Hunan, Peoples R China (författare)
  • Huang, Wen-YiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA (författare)
  • Hurwitz, Lauren M.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA (författare)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany (författare)
  • Knekt, PaulDepartment of Public Health and Welfare, National Institute for Health and Welfare, Helsinki, Finland,Natl Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland (författare)
  • Kubo, TatsuhikoDepartment of Public Health and Health Policy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan,Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Publ Hlth & Hlth Policy, Hiroshima, Japan (författare)
  • Langseth, HildeDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Research, Cancer Registry of Norway, Oslo, Norway,Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England.;Canc Registry Norway, Dept Res, Oslo, Norway (författare)
  • Laughlin, GailHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, CA, San Diego, United States,Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, San Diego, CA 92103 USA (författare)
  • Le Marchand, LoicUniversity of Hawaii Cancer Center, HI, Honolulu, United States,Univ Hawaii Canc Ctr, Honolulu, HI USA (författare)
  • Luostarinen, TapioFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland,Inst Stat & Epidemiol Canc Res, Finnish Canc Registry, Helsinki, Finland (författare)
  • MacInnis, Robert J.Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia,Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia (författare)
  • Mäenpää, Hanna O.Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland,Helsinki Univ Cent Hosp, Dept Oncol, Helsinki, Finland (författare)
  • Männistö, SatuDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland,Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland (författare)
  • Metter, Jeffrey E.Department of Neurology, The University of Tennessee Health Science Center, College of Medicine, TN, Memphis, United States,Univ Tennessee Hlth Sci Ctr, Coll Med, Dept Neurol, Memphis, TN USA (författare)
  • Mikami, KazuyaDepartmemt of Urology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan,Japanese Red Cross Kyoto Daiichi Hosp, Dept Urol, Kyoto, Japan (författare)
  • Mucci, Lorelei A.Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA (författare)
  • Olsen, Anja W.Department of Public Health, Aarhus University, Aarhus, Denmark; Danish Cancer Society, Research Center, Copenhagen, Denmark,Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Danish Canc Soc, Res Ctr, Copenhagen, Denmark (författare)
  • Ozasa, KotaroDepartmemt of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan,Radiat Effects Res Fdn, Dept Epidemiol, Hiroshima, Japan (författare)
  • Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy,Inst Canc Res, Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy (författare)
  • Penney, Kathryn L.Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States,Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA (författare)
  • Platz, Elizabeth A.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States,Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA (författare)
  • Rissanen, HarriDepartment of Public Health and Welfare, National Institute for Health and Welfare, Helsinki, Finland,Natl Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland (författare)
  • Sawada, NorieEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan,Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan (författare)
  • Schenk, Jeannette M.Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA (författare)
  • Stattin, PärUppsala universitet,Urologkirurgi(Swepub:uu)parst892 (författare)
  • Tamakoshi, AkikoHokkaido University Faculty of Medicine, Sapporo, Japan,Hokkaido Univ, Fac Med, Sapporo, Hokkaido, Japan (författare)
  • Thysell, ElinUmeå universitet,Patologi,Umeå Univ, Dept Med Biosci, Umeå, Sweden(Swepub:umu)elnsjn00 (författare)
  • Tsai, Chiaojung JillianDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, NY, New York, United States,Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, 1275 York Ave, New York, NY 10021 USA (författare)
  • Tsugane, ShoichiroEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan,Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan (författare)
  • Vatten, LarsDepartment of Public Health and Nursing, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway,Norwegian Univ Sci & Technol, Fac Med, Dept Publ Hlth & Nursing, Trondheim, Norway (författare)
  • Weiderpass, ElisabeteDirector Office, International Agency for Research on Cancer, World Health Organization, Lyon, France,World Hlth Org, Int Agcy Res Canc, Director Off, Lyon, France (författare)
  • Weinstein, Stephanie J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA (författare)
  • Wilkens, Lynne R.University of Hawaii Cancer Center, HI, Honolulu, United States,Univ Hawaii Canc Ctr, Honolulu, HI USA (författare)
  • Yeap, Bu B.Medical School, University of Western Australia, WA, Perth, Australia; Department of Endocrinology and Diabetes, Fiona Stanley Hospital, WA, Perth, Australia,Univ Western Australia, Med Sch, Perth, WA, Australia.;Fiona Stanley Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia (författare)
  • Allen, Naomi E.Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; UK Biobank Ltd, Stockport, United Kingdom,Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford, England.;UK Biobank Ltd, Stockport, Lancs, England (författare)
  • Key, Timothy J.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England (författare)
  • Travis, Ruth C.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United KingdomUniv Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Cancer: John Wiley & Sons151:7, s. 1033-10460020-71361097-0215

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy