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Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Kliemann, Nathalie (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Ould Ammar, Romain (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Biessy, Carine (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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Gicquiau, Audrey (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Katzke, Verena (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Olsen, Anja (författare)
Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Department of Public Health, Aarhus University, Aarhus, Denmark
Sánchez, Maria-Jose (författare)
Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
Crous-Bou, Marta (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)-Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston,Harvard University,Bellvitge University Hospital-IDIBELL
Pasanisi, Fabrizio (författare)
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
Tin Tin, Sandar (författare)
Nuffield Department of Population Health, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
Perez-Cornago, Aurora (författare)
Nuffield Department of Population Health, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
Aune, Dagfinn (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Oslo New University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
Christakoudi, Sofia (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Inflammation Biology, King's College London, London, United Kingdom
Heath, Alicia K. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Colorado-Yohar, Sandra M. (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia,CIBER Epidemiology and Public Health (CIBERESP)
Grioni, Sara (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy
Skeie, Guri (författare)
Department of Community Medicine, UIT-The Arctic University of Norway, Tromsø, Norway
Sartor, Hanna (författare)
Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Radiology Diagnostics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
Idahl, Annika, 1965- (författare)
Umeå University,Umeå universitet,Obstetrik och gynekologi
Rylander, Charlotta (författare)
Department of Community Medicine, UIT-The Arctic University of Norway, Tromsø, Norway
May, Anne M. (författare)
Julius Center for Health Sciences and Primary care, University Medical Center Utrecht, Utrecht, Netherlands
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Freisling, Heinz (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Playdon, Mary C. (författare)
Department of Nutrition and Integrative Physiology, University of Utah, UT, Salt Lake City, United States; Cancer Control and Population Sciences, Huntsman Cancer Institute, University of Utah, UT, Salt Lake City, United States
Rinaldi, Sabina (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Murphy, Neil (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Huybrechts, Inge (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Dossus, Laure (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Gunter, Marc J. (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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 (creator_code:org_t)
NLM, 2022
2022
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : NLM. - 1055-9965 .- 1538-7755. ; 31:7, s. 1359-1367
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
http://dx.doi.org/10... (free)
https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known.METHODS: The association of metabolically defined body size phenotypes with endometrial cancer risk was investigated in a nested case-control study (817 cases/ 817 controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC). Concentrations of C-peptide were used to define metabolically healthy (MH; <1st tertile) and metabolically unhealthy (MU; ≥1st tertile) status among the control participants. These metabolic health definitions were combined with normal weight (NW); body mass index (BMI)<25 kg/m2 or waist circumference (WC)<80 cm or waist-to-hip ratio (WHR)<0.8) and overweight (OW; BMI≥25 kg/m2 or WC≥80 cm or WHR≥0.8) status, generating four phenotype groups for each anthropometric measure: (i) MH/NW, (ii) MH/OW, (iii) MU/NW, and (iv) MU/OW.RESULTS: In a multivariable-adjusted conditional logistic regression model, compared with MH/NW individuals, endometrial cancer risk was higher among those classified as MU/NW [ORWC, 1.48; 95% confidence interval (CI), 1.05-2.10 and ORWHR, 1.68; 95% CI, 1.21-2.35] and MU/OW (ORBMI, 2.38; 95% CI, 1.73-3.27; ORWC, 2.69; 95% CI, 1.92-3.77 and ORWHR, 1.83; 95% CI, 1.32-2.54). MH/OW individuals were also at increased endometrial cancer risk compared with MH/NW individuals (ORWC, 1.94; 95% CI, 1.24-3.04).CONCLUSIONS: Women with metabolic dysfunction appear to have higher risk of endometrial cancer regardless of their body size. However, OW status raises endometrial cancer risk even among women with lower insulin levels, suggesting that obesity-related pathways are relevant for the development of this cancer beyond insulin.IMPACT: Classifying women by metabolic health may be of greater utility in identifying those at higher risk for endometrial cancer than anthropometry per se.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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