(WFRF:(Masip J)) pers:(Backman Lars)
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- Hird, Emily J.Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, United Kingdom (author)
Dopamine and reward-related vigor in younger and older adults
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- Elsevier,2022
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-198324
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198324URI
- https://doi.org/10.1016/j.neurobiolaging.2022.06.003DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:150411740URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Vigor reflects how motivated people are to respond to stimuli. We previously showed that, on average, humans are more vigorous when a higher rate of reward is available, and that this relationship is modulated by the dopamine precursor levodopa. Dopamine signaling and probabilistic reward learning deteriorate across the adult life span, and thus, the relationship between vigor and reward may also change in aging. We tested this assertion and assessed whether it correlates with D1 dopamine receptor availability, measured using Positron Emission Tomography. We registered response times of 30 older and 30 younger participants during an oddball discrimination task where rewards varied systematically between trials. The average reward rate had a similar impact on vigor in both age groups. There was a weak positive association between ventral striatal dopamine receptor availability and the effect of average reward rate on response time. Overall, the effect of reward on response vigor was similar in younger and older adults, and weakly correlated with dopamine D1 receptor availability.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Aging
- Dopamine
- Reward
- Vigor
Added entries (persons, corporate bodies, meetings, titles ...)
- Beierholm, UlrikDepartment of Psychology, Durham University, Durham, United Kingdom (author)
- De Boer, LiekeAgeing Research Centre, Karolinska Institute, Sweden (author)
- Axelsson, Jan,1966-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi(Swepub:umu)jaax0004 (author)
- Backman, LarsKarolinska Institutet (author)
- Guitart-Masip, MarcKarolinska Institutet (author)
- Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, United KingdomDepartment of Psychology, Durham University, Durham, United Kingdom (creator_code:org_t)
Related titles
- In:Neurobiology of Aging: Elsevier118, s. 34-430197-45801558-1497
Internet link
- https://doi.org/10.1016/j.neurobiolaging.2022.06.003Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1685473/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198324
- https://doi.org/10.1016/j.neurobiolaging.2022.06.003
- http://kipublications.ki.se/Default.aspx?queryparsed=id:150411740
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