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  • Chelcea, Ioana C.Umeå universitet,Kemiska institutionen (author)

Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-07-07
  • American Chemical Society (ACS),2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-198331
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198331URI
  • https://doi.org/10.1021/acs.est.2c01292DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150301802URI
  • https://res.slu.se/id/publ/118619URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Bisphenol A (BPA) is an industrial chemical, which has raised human health and environmental concerns due to its endocrine-disrupting properties. BPA analogues are less well-studied despite their wide use in consumer products. These analogues have been detected in water and aquatic organisms around the world, with some analogues showing toxic effects in various species including fish. Here, we present novel organ-specific time-course distribution data of bisphenol Z (BPZ) in female zebrafish (Danio rerio), including concentrations in the ovaries, liver, and brain, a rarely sampled organ with high toxicological relevance. Furthermore, fish-specific in vitro biotransformation rates were determined for 11 selected bisphenols. A physiologically based toxicokinetic (PBTK) model was adapted for four of these bisphenols, which was able to predict levels in the gonads, liver, and brain as well as the whole body within a 2-5-fold error with respect to experimental data, covering several important target organs of toxicity. In particular, predicted liver concentrations improved compared to currently available PBTK models. Predicted data indicate that studied bisphenols mainly distribute to the carcass and gonads and less to the brain. Our model provides a tool to increase our understanding on the distribution and kinetics of a group of emerging pollutants.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Örn, StefanSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health(Swepub:slu)48782 (author)
  • Hamers, TimoDepartment of Environment & Health, Vrije Universiteit Amsterdam, HV Amsterdam, Netherlands (author)
  • Koekkoek, JaccoDepartment of Environment & Health, Vrije Universiteit Amsterdam, HV Amsterdam, Netherlands (author)
  • Legradi, JessicaDepartment of Environment & Health, Vrije Universiteit Amsterdam, HV Amsterdam, Netherlands (author)
  • Vogs, CarolinaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Karolinska Institutet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Karolinska Institute (author)
  • Andersson, Patrik L.Umeå universitet,Kemiska institutionen(Swepub:umu)paan0001 (author)
  • Umeå universitetKemiska institutionen (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Related titles

  • In:Environmental Science and Technology: American Chemical Society (ACS)56:14, s. 10216-102280013-936X1520-5851

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