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PILRA polymorphism ...
PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk
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- Lopatko Lindman, Karin (author)
- Umeå universitet,Geriatrik,Umeå Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umeå, Sweden.
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- Jonsson, Caroline (author)
- Umeå universitet,Geriatrik,Umeå Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umeå, Sweden.
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- Weidung, Bodil (author)
- Uppsala universitet,Umeå universitet,Geriatrik,Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden,Umeå Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umeå, Sweden.
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- Olsson, Jan (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Univ, Dept Clin Microbiol, Umeå, Sweden.
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- Pandey, Janardan P. (author)
- Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, United States,Med Univ South Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA.
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- Prokopenko, Dmitry (author)
- Genetics and Aging Unit, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, MA, Boston, United States; Harvard Medical School, MA, Boston, United States,Massachusetts Gen Hosp, Dept Neurol, McCance Ctr Brain Hlth, Genet & Aging Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Tanzi, Rudolph E. (author)
- Genetics and Aging Unit, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, MA, Boston, United States; Harvard Medical School, MA, Boston, United States,Massachusetts Gen Hosp, Dept Neurol, McCance Ctr Brain Hlth, Genet & Aging Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Avdelningen för hållbar hälsa,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.
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- Eriksson, Sture (author)
- Umeå universitet,Geriatrik,Avdelningen för hållbar hälsa,Umeå Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umeå, Sweden.;Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.
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- Elgh, Fredrik, 1957- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Univ, Dept Clin Microbiol, Umeå, Sweden.
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- Lövheim, Hugo, 1981- (author)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Geriatrik,Umeå Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umeå, Sweden.;Umeå Univ, Wallenberg Ctr Mol Med WCMM, Umeå, Sweden.
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(creator_code:org_t)
- 2022-08-02
- 2022
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 12:1
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Abstract
Subject headings
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- PILRA (rs1859788 A > G) has been suggested to be a protective variant for Alzheimer’s disease (AD) and is an entry co-receptor for herpes simplex virus-1. We conducted a nested case–control study of 360 1:1-matched AD subjects. Interactions between the PILRA-A allele, APOE risk variants (ε3/ε4 or ε4/ε4) and GM17 for AD risk were modelled. The associations were cross-validated using two independent whole-genome sequencing datasets. We found negative interactions between PILRA-A and GM17 (OR 0.72, 95% CI 0.52–1.00) and between PILRA-A and APOE risk variants (OR 0.56, 95% CI 0.32–0.98) in the discovery dataset. In the replication cohort, a joint effect of PILRA and PILRA × GM 17/17 was observed for the risk of developing AD (p.02). Here, we report a negative effect modification by PILRA on APOE and GM17 high-risk variants for future AD risk in two independent datasets. This highlights the complex genetics of AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
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Lopatko Lindman, ...
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Jonsson, Carolin ...
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Weidung, Bodil
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Olsson, Jan
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Pandey, Janardan ...
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Prokopenko, Dmit ...
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Tanzi, Rudolph E ...
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Hallmans, Göran, ...
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Eriksson, Sture
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Elgh, Fredrik, 1 ...
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Lövheim, Hugo, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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Umeå University
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Uppsala University