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Search: (WFRF:(Hallmans Göran 1947 )) srt2:(2020-2022) > PILRA polymorphism ...

  • Lopatko Lindman, KarinUmeå universitet,Geriatrik,Umeå Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umeå, Sweden. (author)

PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-08-02
  • Nature Publishing Group,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-198480
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198480URI
  • https://doi.org/10.1038/s41598-022-17058-6DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482781URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • PILRA (rs1859788 A > G) has been suggested to be a protective variant for Alzheimer’s disease (AD) and is an entry co-receptor for herpes simplex virus-1. We conducted a nested case–control study of 360 1:1-matched AD subjects. Interactions between the PILRA-A allele, APOE risk variants (ε3/ε4 or ε4/ε4) and GM17 for AD risk were modelled. The associations were cross-validated using two independent whole-genome sequencing datasets. We found negative interactions between PILRA-A and GM17 (OR 0.72, 95% CI 0.52–1.00) and between PILRA-A and APOE risk variants (OR 0.56, 95% CI 0.32–0.98) in the discovery dataset. In the replication cohort, a joint effect of PILRA and PILRA × GM 17/17 was observed for the risk of developing AD (p.02). Here, we report a negative effect modification by PILRA on APOE and GM17 high-risk variants for future AD risk in two independent datasets. This highlights the complex genetics of AD.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Jonsson, CarolineUmeå universitet,Geriatrik,Umeå Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umeå, Sweden. (author)
  • Weidung, BodilUppsala universitet,Umeå universitet,Geriatrik,Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden,Umeå Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umeå, Sweden.(Swepub:uu)bodwe750 (author)
  • Olsson, JanUmeå universitet,Institutionen för klinisk mikrobiologi,Umeå Univ, Dept Clin Microbiol, Umeå, Sweden.(Swepub:umu)jaol0001 (author)
  • Pandey, Janardan P.Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, United States,Med Univ South Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA. (author)
  • Prokopenko, DmitryGenetics and Aging Unit, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, MA, Boston, United States; Harvard Medical School, MA, Boston, United States,Massachusetts Gen Hosp, Dept Neurol, McCance Ctr Brain Hlth, Genet & Aging Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA. (author)
  • Tanzi, Rudolph E.Genetics and Aging Unit, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, MA, Boston, United States; Harvard Medical School, MA, Boston, United States,Massachusetts Gen Hosp, Dept Neurol, McCance Ctr Brain Hlth, Genet & Aging Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA. (author)
  • Hallmans, Göran,1947-Umeå universitet,Avdelningen för hållbar hälsa,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.(Swepub:umu)goha0001 (author)
  • Eriksson, StureUmeå universitet,Geriatrik,Avdelningen för hållbar hälsa,Umeå Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umeå, Sweden.;Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.(Swepub:umu)ster0022 (author)
  • Elgh, Fredrik,1957-Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Univ, Dept Clin Microbiol, Umeå, Sweden.(Swepub:umu)frkelh76 (author)
  • Lövheim, Hugo,1981-Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Geriatrik,Umeå Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umeå, Sweden.;Umeå Univ, Wallenberg Ctr Mol Med WCMM, Umeå, Sweden.(Swepub:umu)huolom01 (author)
  • Umeå universitetGeriatrik (creator_code:org_t)

Related titles

  • In:Scientific Reports: Nature Publishing Group12:12045-2322

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