SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Lagergren K.)
 

Search: WFRF:(Lagergren K.) > Neoadjuvant Chemora...

  • Nilsson, MagnusKarolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Comprehens Canc Ctr, Dept Upper Abdominal Dis, Stockholm, Sweden. (author)

Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed : The Study Protocol for the Randomized Controlled NEEDS Trial

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-07-13
  • Frontiers Media S.A.2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-198490
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198490URI
  • https://doi.org/10.3389/fonc.2022.917961DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150378425URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482089URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187397URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Research Council [2019-00423]; Swedish Cancer Society [200736]; Region of Stockholm [20200119]
  • Background: The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. This multimodal treatment leads to around 60% overall 5-year survival, yet with impaired post-surgical quality of life. Observational studies indicate that curatively intended chemoradiotherapy, so-called definitive chemoradiotherapy (dCRT) followed by surveillance of the primary tumor site and regional lymph node stations and surgery only when needed to ensure local tumor control, may lead to similar survival as nCRT with surgery, but with considerably less impairment of quality of life. This trial aims to demonstrate that dCRT, with selectively performed salvage esophagectomy only when needed to achieve locoregional tumor control, is non-inferior regarding overall survival, and superior regarding health-related quality of life (HRQOL), compared to nCRT followed by mandatory surgery, in patients with operable, locally advanced ESCC.Methods: This is a pragmatic open-label, randomized controlled phase III, multicenter trial with non-inferiority design with regard to the primary endpoint overall survival and a superiority hypothesis for the experimental intervention dCRT with regard to the main secondary endpoint global HRQOL one year after randomization. The control intervention is nCRT followed by preplanned surgery and the experimental intervention is dCRT followed by surveillance and salvage esophagectomy only when needed to secure local tumor control. A target sample size of 1200 randomized patients is planned in order to reach 462 events (deaths) during follow-up.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Olafsdottir, HallaKarolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Thorac Oncol Ctr, Karolinska Comprehens Canc Ctr, Stockholm, Sweden. (author)
  • Alexandersson von Döbeln, GabriellaKarolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Thorac Oncol Ctr, Karolinska Comprehens Canc Ctr, Stockholm, Sweden. (author)
  • Villegas, FernandaSection of Radiotherapy Physics and Engineering, Department of Medical Radiation Physics and Nuclear Medicine, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Karolinska Comprehens Canc Ctr, Dept Med Radiat Phys & Nucl Med, Sect Radiotherapy Phys & Engn, Stockholm, Sweden. (author)
  • Gagliardi, GiovannaSection of Radiotherapy Physics and Engineering, Department of Medical Radiation Physics and Nuclear Medicine, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Karolinska Comprehens Canc Ctr, Dept Med Radiat Phys & Nucl Med, Sect Radiotherapy Phys & Engn, Stockholm, Sweden. (author)
  • Hellström, MatsCenter for Clinical Cancer Studies, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Ctr Clin Canc Studies, Karolinska Comprehens Canc Ctr, Stockholm, Sweden. (author)
  • Wang, Qiao-LiKarolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Surg, Stockholm, Sweden. (author)
  • Johansson, HemmingCenter for Clinical Cancer Studies, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Karolinska Univ Hosp, Ctr Clin Canc Studies, Karolinska Comprehens Canc Ctr, Stockholm, Sweden.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden. (author)
  • Gebski, ValNHMRC Clinical, Trials Centre, University of Sydney, NSW, Sydney, Australia,Univ Sydney, NHMRC Clin Trials Ctr, Sydney, NSW, Australia. (author)
  • Hedberg, Jakob,1972-Uppsala universitet,Gastrointestinalkirurgi,Uppsala Univ Hosp, Sweden(Swepub:uu)jakhe890 (author)
  • Klevebro, FredrikKarolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Comprehens Canc Ctr, Dept Upper Abdominal Dis, Stockholm, Sweden. (author)
  • Markar, SherazNuffield Department of Surgery, University of Oxford, Oxford, United Kingdom; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden,Univ Oxford, Nuffield Dept Surg, Oxford, England.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden. (author)
  • Smyth, ElizabethDepartment of Oncology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom,Cambridge Univ Hosp Natl Hlth Serv Fdn Trust, Dept Oncol, Cambridge, England. (author)
  • Lagergren, PernillaKarolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Imperial Coll London, Dept Surg & Canc, London, England. (author)
  • Al-Haidari, GhazwanDepartment of Oncology, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Dept Oncol, Oslo, Norway. (author)
  • Rekstad, Lars CatoDepartment of Gastrointestinal Surgery, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway,Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Gastrointestinal Surg, Trondheim, Norway. (author)
  • Aahlin, Eirik KjusDepartment of GI and HPB Surgery, University Hospital of Northern Norway, Tromsø, Norway,Univ Hosp Northern Norway, Dept GI & HPB Surg, Tromso, Norway. (author)
  • Wallner, Bengt,1962-Umeå universitet,Kirurgi,Umeå Univ, Dept Surg & Perioperat Sci, Surg, Umeå, Sweden.(Swepub:umu)bewa0005 (author)
  • Edholm, DavidLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)daved38 (author)
  • Johansson, JanDepartment of Surgery, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Dept Surg, Lund, Sweden. (author)
  • Szabo, EvaDepartment of Surgery, University Hospital of Örebro, Örebro, Sweden,Univ Hosp Örebro, Dept Surg, Örebro, Sweden. (author)
  • Reynolds, John V.Department of Surgery, Trinity St James’s Cancer Institute, Dublin, Ireland,Trinity St Jamess Canc Inst, Dept Surg, Dublin, Ireland. (author)
  • Pramesh, C.S.Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India,Homi Bhabha Natl Inst, Tata Mem Ctr, Mumbai, India. (author)
  • Mummudi, NaveenTata Memorial Centre, Homi Bhabha National Institute, Mumbai, India,Homi Bhabha Natl Inst, Tata Mem Ctr, Mumbai, India. (author)
  • Joshi, AmitTata Memorial Centre, Homi Bhabha National Institute, Mumbai, India,Homi Bhabha Natl Inst, Tata Mem Ctr, Mumbai, India. (author)
  • Ferri, LorenzoDepartment of Thoracic Surgery, McGill University Health Centre, QC, Montreal, Canada,McGill Univ Hlth Ctr, Dept Thorac Surg, Montreal, PQ, Canada. (author)
  • Wong, Rebecca K.S.Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, ON, Toronto, Canada; Department of Radiation Oncology, University of Toronto, ON, Toronto, Canada,Univ Hlth Network, Princess Margaret Canc Ctr, Radiat Med Program, Toronto, ON, Canada.;Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada. (author)
  • O’Callaghan, ChrisCanadian Cancer Trials Group, ON, Kingston, Canada (author)
  • Lukovic, JelenaRadiation Medicine Program, Princess Margaret Cancer Center, University Health Network, ON, Toronto, Canada; Department of Radiation Oncology, University of Toronto, ON, Toronto, Canada,Univ Hlth Network, Princess Margaret Canc Ctr, Radiat Med Program, Toronto, ON, Canada.;Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada. (author)
  • Chan, Kelvin K.W.Sunnybrook Health Sciences Centre, University of Toronto, ON, Toronto, Canada,Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada. (author)
  • Leong, TrevorSir Peter MacCallum, Department of Oncology, Peter MacCallum Cancer Centre, University of Melbourne, VIC, Melbourne, Australia,Univ Melbourne, Peter MacCallum Canc Ctr, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia. (author)
  • Barbour, AndrewAcademy of Surgery, University of Queensland, Princess Alexandra Hospital, QLD, Brisbane, Australia,Univ Queensland, Princess Alexandra Hosp, Acad Surg, Brisbane, Qld, Australia. (author)
  • Smithers, MarkAcademy of Surgery, University of Queensland, Princess Alexandra Hospital, QLD, Brisbane, Australia,Univ Queensland, Princess Alexandra Hosp, Acad Surg, Brisbane, Qld, Australia. (author)
  • Li, YinDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,Chinese Acad Med Sci & Peking Union Med Coll, Canc Canc Hosp, Dept Thorac Surg, Natl Canc Ctr,Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China. (author)
  • Kang, XiaozhengDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,Chinese Acad Med Sci & Peking Union Med Coll, Canc Canc Hosp, Dept Thorac Surg, Natl Canc Ctr,Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China. (author)
  • Kong, Feng-MingThoracic Oncology Center, HKU Shenzhen Hospital, Hong Kong University Li Ka Shing Medical School, Shenzhen, China,Hong Kong Univ Li Ka Shing Med Sch, HKU Shenzhen Hosp, Thorac Oncol Ctr, Shenzhen, Peoples R China. (author)
  • Chao, Yin-KaiDepartment of thoracic surgery, Chang Gung Memorial Hospital-Linkou, Chang Gung University, Taoyuan, Taiwan,Chang Gung Univ, Chang Gung Mem Hosp Linkou, Dept thorac Surg, Taoyuan, Taiwan. (author)
  • Crosby, TomDepartment of Clinical Oncology, Velindre Cancer Centre, Cardiff, United Kingdom,Velindre Canc Ctr, Dept Clin Oncol, Cardiff, Wales. (author)
  • Bruns, ChristianeDepartment of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany,Univ Hosp Cologne, Dept Gen Visceral & Canc Surg, Cologne, Germany. (author)
  • van Laarhoven, HannekeDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam, Netherlands,Amsterdam Univ Med Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands. (author)
  • van Berge Henegouwen, MarkDepartment of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands,Amsterdam Univ Med Ctr, Univ Amsterdam, Canc Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands. (author)
  • van Hillegersberg, RichardDepartmentof Surgery, University Medical Center Utrecht, Utrecht, Netherlands,Univ Med Ctr Utrecht, Dept Surg, Utrecht, Netherlands. (author)
  • Rosati, RiccardoDepartment of Gastrointestinal Surgery, San Rafaele Hospital, Vita Salute University, Milan, Italy,Univ Vita Salute San Raffaele, San Rafaele Hosp, Dept Gastrointestinal Surg, Milan, Italy. (author)
  • Piessen, GuillaumeUniv. Lille, CNRS, CHU Lille, UMR9020-U1277 - CANTHER – Cancer Heterogeneity Plasticity and Resistance to Therapies, Inserm, Lille, France,Univ Lille, CNRS, Inserm, CHU Lille,UMR9020 U1277 CANTHER Canc Heterogene Pl, F-59000 Lille, France. (author)
  • de Manzoni, GiovanniUpper GI Surgery Division, University of Verona, Verona, Italy,Univ Verona, Upper GI Surg Div, Verona, Italy. (author)
  • Lordick, FlorianUniversity Cancer Center Leipzig, Leipzig University Medical Center, Leipzig, Germany,Leipzig Univ Med Ctr, Univ Canc Ctr Leipzig, Leipzig, Germany. (author)
  • Karolinska InstitutetKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Comprehens Canc Ctr, Dept Upper Abdominal Dis, Stockholm, Sweden. (creator_code:org_t)

Related titles

  • In:Frontiers in Oncology: Frontiers Media S.A.122234-943X

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view