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Sökning: WFRF:(Lundberg Pernilla) > (2020-2024) > Oral characteristic...

Oral characteristics in adult individuals with periodontal Ehlers-Danlos syndrome

Lepperdinger, Ulrike (författare)
Department of Operative and Restorative Dentistry, Medical University of Innsbruck, Innsbruck, Austria
Angwin, Chloe (författare)
National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
Milnes, Di (författare)
Genetic Health Queensland, Royal Brisbane and Women's Hospital, QLD, Herston, Australia
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Sobey, Glenda (författare)
Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
Ghali, Neeti (författare)
National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
Johnson, Diana (författare)
Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
Brady, Angela F. (författare)
National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
Kammin, Tammy (författare)
Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
Bowen, Jessica M. (författare)
Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
Gröbner, Rebekka (författare)
Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria
Lundberg, Pernilla, 1965- (författare)
Umeå universitet,Institutionen för odontologi
Scott, James (författare)
Academic Unit of Restorative Dentistry, Sheffield University, Sheffield, United Kingdom
Zschocke, Johannes (författare)
Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria
van Dijk, Fleur S. (författare)
National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
Kapferer-Seebacher, Ines (författare)
Department of Operative and Restorative Dentistry, Medical University of Innsbruck, Innsbruck, Austria
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 (creator_code:org_t)
2022-07-29
2022
Engelska.
Ingår i: Journal of Clinical Periodontology. - : John Wiley & Sons. - 0303-6979 .- 1600-051X. ; 49:12, s. 1244-1252
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Aim: Periodontal Ehlers-Danlos syndrome (pEDS) is a monogenic type of Ehlers-Danlos syndrome characterized by periodontal destruction at a young age. The present study aimed to document the oral phenotype of pEDS based on prospective clinical investigations.Materials and Methods: Thirty-five adult individuals from 13 families with a clinically and genetically confirmed diagnosis of pEDS underwent a systematic oral assessment.Results: Periodontitis stage 3 or 4 or edentulism due to periodontal destruction were diagnosed in 94% of the individuals. First permanent tooth loss was reported at the age of 21.5 years (median; range 13–43 years). Deep periodontal pockets were infrequent, with 94% measuring <4 mm. However, there was increased clinical attachment loss (CAL) averaging 8 mm (range 4–13 mm), and the probability of being edentate between the age of 35 and 44 years was 28–47% compared with less than 0.25% of the general population. Radiographic anomalous findings were only found in a portion of subjects and consisted of fused roots of maxillary second molars (81%), root hypoplasia (57%), taurodontism (26%) and tooth rotation of premolars (67%). As such, radiographic findings are not considered common characteristics of pEDS.Conclusions: Characteristic oral traits of pEDS in adults are severe CAL with shallow probing depths and marked gingival recession. This is complemented by a lack of attached gingiva. These indications need to be paralleled by genetic analyses to diagnose pEDS unambiguously.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

attached gingiva
C1R
C1S
Ehlers-Danlos syndrome
periodontitis
odontologi
Odontology

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