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  • Lepperdinger, UlrikeDepartment of Operative and Restorative Dentistry, Medical University of Innsbruck, Innsbruck, Austria (författare)

Oral characteristics in adult individuals with periodontal Ehlers-Danlos syndrome

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-07-29
  • John Wiley & Sons,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-198510
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198510URI
  • https://doi.org/10.1111/jcpe.13698DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Aim: Periodontal Ehlers-Danlos syndrome (pEDS) is a monogenic type of Ehlers-Danlos syndrome characterized by periodontal destruction at a young age. The present study aimed to document the oral phenotype of pEDS based on prospective clinical investigations.Materials and Methods: Thirty-five adult individuals from 13 families with a clinically and genetically confirmed diagnosis of pEDS underwent a systematic oral assessment.Results: Periodontitis stage 3 or 4 or edentulism due to periodontal destruction were diagnosed in 94% of the individuals. First permanent tooth loss was reported at the age of 21.5 years (median; range 13–43 years). Deep periodontal pockets were infrequent, with 94% measuring <4 mm. However, there was increased clinical attachment loss (CAL) averaging 8 mm (range 4–13 mm), and the probability of being edentate between the age of 35 and 44 years was 28–47% compared with less than 0.25% of the general population. Radiographic anomalous findings were only found in a portion of subjects and consisted of fused roots of maxillary second molars (81%), root hypoplasia (57%), taurodontism (26%) and tooth rotation of premolars (67%). As such, radiographic findings are not considered common characteristics of pEDS.Conclusions: Characteristic oral traits of pEDS in adults are severe CAL with shallow probing depths and marked gingival recession. This is complemented by a lack of attached gingiva. These indications need to be paralleled by genetic analyses to diagnose pEDS unambiguously.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Angwin, ChloeNational Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom (författare)
  • Milnes, DiGenetic Health Queensland, Royal Brisbane and Women's Hospital, QLD, Herston, Australia (författare)
  • Sobey, GlendaEhlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom (författare)
  • Ghali, NeetiNational Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom (författare)
  • Johnson, DianaEhlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom (författare)
  • Brady, Angela F.National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom (författare)
  • Kammin, TammyEhlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom (författare)
  • Bowen, Jessica M.Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom (författare)
  • Gröbner, RebekkaInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria (författare)
  • Lundberg, Pernilla,1965-Umeå universitet,Institutionen för odontologi(Swepub:umu)pelu0004 (författare)
  • Scott, JamesAcademic Unit of Restorative Dentistry, Sheffield University, Sheffield, United Kingdom (författare)
  • Zschocke, JohannesInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria (författare)
  • van Dijk, Fleur S.National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom (författare)
  • Kapferer-Seebacher, InesDepartment of Operative and Restorative Dentistry, Medical University of Innsbruck, Innsbruck, Austria (författare)
  • Department of Operative and Restorative Dentistry, Medical University of Innsbruck, Innsbruck, AustriaNational Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Periodontology: John Wiley & Sons49:12, s. 1244-12520303-69791600-051X

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