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Oral characteristic...
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Lepperdinger, UlrikeDepartment of Operative and Restorative Dentistry, Medical University of Innsbruck, Innsbruck, Austria
(författare)
Oral characteristics in adult individuals with periodontal Ehlers-Danlos syndrome
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-07-29
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John Wiley & Sons,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-198510
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198510URI
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https://doi.org/10.1111/jcpe.13698DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Aim: Periodontal Ehlers-Danlos syndrome (pEDS) is a monogenic type of Ehlers-Danlos syndrome characterized by periodontal destruction at a young age. The present study aimed to document the oral phenotype of pEDS based on prospective clinical investigations.Materials and Methods: Thirty-five adult individuals from 13 families with a clinically and genetically confirmed diagnosis of pEDS underwent a systematic oral assessment.Results: Periodontitis stage 3 or 4 or edentulism due to periodontal destruction were diagnosed in 94% of the individuals. First permanent tooth loss was reported at the age of 21.5 years (median; range 13–43 years). Deep periodontal pockets were infrequent, with 94% measuring <4 mm. However, there was increased clinical attachment loss (CAL) averaging 8 mm (range 4–13 mm), and the probability of being edentate between the age of 35 and 44 years was 28–47% compared with less than 0.25% of the general population. Radiographic anomalous findings were only found in a portion of subjects and consisted of fused roots of maxillary second molars (81%), root hypoplasia (57%), taurodontism (26%) and tooth rotation of premolars (67%). As such, radiographic findings are not considered common characteristics of pEDS.Conclusions: Characteristic oral traits of pEDS in adults are severe CAL with shallow probing depths and marked gingival recession. This is complemented by a lack of attached gingiva. These indications need to be paralleled by genetic analyses to diagnose pEDS unambiguously.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Angwin, ChloeNational Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
(författare)
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Milnes, DiGenetic Health Queensland, Royal Brisbane and Women's Hospital, QLD, Herston, Australia
(författare)
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Sobey, GlendaEhlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
(författare)
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Ghali, NeetiNational Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
(författare)
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Johnson, DianaEhlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
(författare)
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Brady, Angela F.National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
(författare)
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Kammin, TammyEhlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
(författare)
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Bowen, Jessica M.Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
(författare)
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Gröbner, RebekkaInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria
(författare)
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Lundberg, Pernilla,1965-Umeå universitet,Institutionen för odontologi(Swepub:umu)pelu0004
(författare)
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Scott, JamesAcademic Unit of Restorative Dentistry, Sheffield University, Sheffield, United Kingdom
(författare)
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Zschocke, JohannesInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria
(författare)
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van Dijk, Fleur S.National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
(författare)
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Kapferer-Seebacher, InesDepartment of Operative and Restorative Dentistry, Medical University of Innsbruck, Innsbruck, Austria
(författare)
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Department of Operative and Restorative Dentistry, Medical University of Innsbruck, Innsbruck, AustriaNational Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Clinical Periodontology: John Wiley & Sons49:12, s. 1244-12520303-69791600-051X
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Lepperdinger, Ul ...
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Angwin, Chloe
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Milnes, Di
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Sobey, Glenda
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Ghali, Neeti
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Johnson, Diana
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visa fler...
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Brady, Angela F.
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Kammin, Tammy
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Bowen, Jessica M ...
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Gröbner, Rebekka
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Lundberg, Pernil ...
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Scott, James
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Zschocke, Johann ...
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van Dijk, Fleur ...
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Kapferer-Seebach ...
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