Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

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Byun, JinyoungInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States (författare)

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

Artikel/kapitelEngelska2022

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2022-08-01
Nature Research,2022
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:umu-198568
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198568URI
https://doi.org/10.1038/s41588-022-01115-xDOI
https://lup.lub.lu.se/record/3e3e0ce2-754d-4752-9947-4e1b68ab030fURI

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To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
DNA binding protein
FUBP1 protein, human
RNA binding protein
genetic predisposition
genetics
genome-wide association study
human
lung tumor
meta analysis
quantitative trait locus
single nucleotide polymorphism
DNA-Binding Proteins
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Lung Neoplasms
Polymorphism, Single Nucleotide
Quantitative Trait Loci
RNA-Binding Proteins

Biuppslag (personer, institutioner, konferenser, titlar ...)

Han, YounghunInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States (författare)
Li, YafangInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States (författare)
Xia, JunInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States (författare)
Long, ErpingDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Choi, JiyeonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Xiao, XiangjunInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States (författare)
Zhu, MengDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
Zhou, WenInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States (författare)
Sun, RyanDepartment of Biostatistics, University of Texas, M.D. Anderson Cancer Center, TX, Houston, United States (författare)
Bossé, YohanInstitut universitaire de cardiologie et de pneumologie de Québec – Université Laval, Department of Molecular Medicine, Laval University, QC, Quebec City, Canada (författare)
Song, ZhuoyiInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States (författare)
Schwartz, AnnDepartment of Oncology, Wayne State University School of Medicine, MI, Detroit, United States; Karmanos Cancer Institute, MI, Detroit, United States (författare)
Lusk, ChristineDepartment of Oncology, Wayne State University School of Medicine, MI, Detroit, United States; Karmanos Cancer Institute, MI, Detroit, United States (författare)
Rafnar, ThorunndeCODE genetics/Amgen Sturlugata 8, Reykjavik, Iceland (författare)
Stefansson, KarideCODE genetics/Amgen Sturlugata 8, Reykjavik, Iceland (författare)
Zhang, TongwuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Zhao, WeiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Pettit, Rowland W.Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States (författare)
Liu, YanhongSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States (författare)
Li, XihaoDepartment of Biostatistics, Harvard TH Chan School of Public Health, MA, Boston, United States (författare)
Zhou, HufengDepartment of Biostatistics, Harvard TH Chan School of Public Health, MA, Boston, United States (författare)
Walsh, Kyle M.Duke Cancer Institute, Duke University Medical Center, NC, Durham, United States (författare)
Gorlov, IvanInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States (författare)
Gorlova, OlgaInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States (författare)
Zhu, DakaiInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States (författare)
Rosenberg, Susan M.Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States (författare)
Pinney, SusanUniversity of Cincinnati College of Medicine, OH, Cincinnati, United States (författare)
Bailey-Wilson, Joan E.National Human Genome Research Institute, NIH, MD, Baltimore, United States (författare)
Mandal, DiptasriLouisiana State University Health Sciences Center, LA, New Orleans, United States (författare)
de Andrade, MarizaMayo Clinic, College of Medicine, MN, Rochester, United States (författare)
Gaba, ColetteThe University of Toledo College of Medicine and Life Sciences, University of Toledo, OH, Toledo, United States (författare)
Willey, James C.The University of Toledo College of Medicine and Life Sciences, University of Toledo, OH, Toledo, United States (författare)
You, MingCenter for Cancer Prevention, Houston Methodist Research Institute, TX, Houston, United States (författare)
Anderson, MarshallUniversity of Cincinnati College of Medicine, OH, Cincinnati, United States (författare)
Wiencke, John K.Department of Neurological Surgery, University of California, San Francisco, CA, San Francisco, United States (författare)
Albanes, DemetriusDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Lam, StephanDepartment of Integrative Oncology, BC Cancer, BC, Vancouver, Canada (författare)
Tardon, AdoninaPublic Health Department, University of Oviedo, ISPA and CIBERESP, Asturias, Spain (författare)
Chen, ChuProgram in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Baylor College of Medicine (författare)
Goodman, GarySwedish Cancer Institute, WA, Seattle, United States (författare)
Bojeson, StigDepartment of Clinical Biochemistry, Herlev Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
Brenner, HermannDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
Landi, Maria TeresaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Chanock, Stephen J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Johansson, MattiasSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
Muley, ThomasDivision of Cancer Epigenomics, DKFZ – German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany (författare)
Risch, AngelaDivision of Cancer Epigenomics, DKFZ – German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany; Department of Biosciences and Medical Biology, Allergy-Cancer-BioNano Research Centre, University of Salzburg, Salzburg, Austria; Cancer Cluster Salzburg, Salzburg, Austria (författare)
Wichmann, H.-ErichInstitute of Epidemiology, Helmholtz Center, Munich, Germany (författare)
Bickeböller, HeikeDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany (författare)
Christiani, David C.Department of Epidemiology, Harvard T.H.Chan School of Public Health, MA, Boston, United States (författare)
Rennert, GadClalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel (författare)
Arnold, SusanneUniversity of Kentucky, Markey Cancer Center, KY, Lexington, United States (författare)
Field, John K.Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom (författare)
Shete, SanjayDepartment of Biostatistics, University of Texas, M.D. Anderson Cancer Center, TX, Houston, United States; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, TX, Houston, United States (författare)
Le Marchand, LoicEpidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States (författare)
Melander, O.Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (författare)
Brunnstrom, H.Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-hsb (författare)
Liu, GeoffreyUniversity Health Network- The Princess Margaret Cancer Centre, Ontario, Toronto, Canada (författare)
Andrew, Angeline S.Departments of Epidemiology and Community and Family Medicine, Dartmouth College, NH, Hanover, United States (författare)
Kiemeney, Lambertus A.Radboud University Medical Center, Nijmegen, Netherlands (författare)
Shen, HongbingDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
Zienolddiny, ShanbehNational Institute of Occupational Health, Oslo, Norway (författare)
Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002 (författare)
Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025 (författare)
Caporaso, NeilDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Cox, AngelaDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom (författare)
Hong, Yun-ChulDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea (författare)
Yuan, Jian-MinUPMC Hillman Cancer Center and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States (författare)
Lazarus, PhilipDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States (författare)
Schabath, Matthew B.Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States (författare)
Aldrich, Melinda C.Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
Patel, AlpaAmerican Cancer Society, GA, Atlanta, United States (författare)
Lan, QingDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Rothman, NathanielDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Taylor, FionaDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom (författare)
Kachuri, LindaDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, San Francisco, United States (författare)
Witte, John S.Department of Epidemiology and Population Health, Stanford University, CA, Stanford, United States (författare)
Sakoda, Lori C.Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States (författare)
Spitz, MargaretSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States (författare)
Brennan, PaulSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
Lin, XihongDepartment of Biostatistics, Harvard TH Chan School of Public Health, MA, Boston, United States (författare)
McKay, JamesSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
Hung, Rayjean J.Lunenfeld-Tanenbaum Research Institute, Sinai Health System, ON, Toronto, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, ON, Toronto, Canada (författare)
Amos, Christopher I.Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United StatesInstitute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States (creator_code:org_t)
et al.

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Ingår i:Nature Genetics: Nature Research54:8, s. 1167-11771061-40361546-1718

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Av författaren/redakt...: Byun, Jinyoung; Han, Younghun; Li, Yafang; Xia, Jun; Long, Erping; Choi, Jiyeon; visa fler...; Xiao, Xiangjun; Zhu, Meng; Zhou, Wen; Sun, Ryan; Bossé, Yohan; Song, Zhuoyi; Schwartz, Ann; Lusk, Christine; Rafnar, Thorunn; Stefansson, Kari; Zhang, Tongwu; Zhao, Wei; Pettit, Rowland ...; Liu, Yanhong; Li, Xihao; Zhou, Hufeng; Walsh, Kyle M.; Gorlov, Ivan; Gorlova, Olga; Zhu, Dakai; Rosenberg, Susan ...; Pinney, Susan; Bailey-Wilson, J ...; Mandal, Diptasri; de Andrade, Mari ...; Gaba, Colette; Willey, James C.; You, Ming; Anderson, Marsha ...; Wiencke, John K.; Albanes, Demetri ...; Lam, Stephan; Tardon, Adonina; Chen, Chu; Goodman, Gary; Bojeson, Stig; Brenner, Hermann; Landi, Maria Ter ...; Chanock, Stephen ...; Johansson, Matti ...; Muley, Thomas; Risch, Angela; Wichmann, H.-Eri ...; Bickeböller, Hei ...; Christiani, Davi ...; Rennert, Gad; Arnold, Susanne; Field, John K.; Shete, Sanjay; Le Marchand, Loi ...; Melander, O.; Brunnstrom, H.; Liu, Geoffrey; Andrew, Angeline ...; Kiemeney, Lamber ...; Shen, Hongbing; Zienolddiny, Sha ...; Grankvist, Kjell; Johansson, Mikae ...; Caporaso, Neil; Cox, Angela; Hong, Yun-Chul; Yuan, Jian-Min; Lazarus, Philip; Schabath, Matthe ...; Aldrich, Melinda ...; Patel, Alpa; Lan, Qing; Rothman, Nathani ...; Taylor, Fiona; Kachuri, Linda; Witte, John S.; Sakoda, Lori C.; Spitz, Margaret; Brennan, Paul; Lin, Xihong; McKay, James; Hung, Rayjean J.; Amos, Christophe ...; visa färre...

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