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Oral Microbiota Pro...
Abstract
Ämnesord
Stäng
- Microbiota has been associated with autoimmune diseases, with nasal Staphylococcus aureus being implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV). Little is known about the role of oral microbiota in AAV. In this study, levels of IgG antibodies to 53 oral bacterial species/subspecies were screened using immunoblotting in plasma/serum in pre-symptomatic AAV-individuals (n = 85), matched controls, and established AAV-patients (n = 78). Saliva microbiota from acute-AAV and controls was sequenced from 16s rDNA amplicons. Information on dental status was extracted from a national register. IgG levels against oral bacteria were lower in established AAV versus pre-AAV and controls. Specifically, pre-AAV samples had, compared to controls, a higher abundance of periodontitis-associated species paralleling more signs of periodontitis in established AAV-patients than controls. Saliva microbiota in acute-AAV showed higher within-sample diversity but fewer detectable amplicon-sequence variants and taxa in their core microbiota than controls. Acute-AAV was not associated with increased abundance of periodontal bacteria but species in, e.g., Arthrospira, Staphylococcus, Lactobacillus, and Scardovia. In conclusion, the IgG profiles against oral bacteria differed between pre-AAV, established AAV, and controls, and microbiota profiles between acute AAV and controls. The IgG shift from a pre-symptomatic stage to established disease cooccurred with treatment of immunosuppression and/or antibiotics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Nyckelord
- anti-neutrophil cytoplasmatic antibody–associated vasculitis
- caries
- granulomatosis with polyangiitis (GPA)
- IgG
- microscopic polyangiitis (MPA)
- myeloperoxidase (MPO)-ANCA
- oral microbiota
- periodontal disease
- proteinase 3 (PR3)-ANCA
- vasculitis
- anti-neutrophil cytoplasmatic antibody–associated vasculitis
- caries
- granulomatosis with polyangiitis (GPA)
- IgG
- microscopic polyangiitis (MPA)
- myeloperoxidase (MPO)-ANCA
- oral microbiota
- periodontal disease
- proteinase 3 (PR3)-ANCA
- vasculitis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Esberg, Anders
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Johansson, Linda
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Berglin, Ewa, MD ...
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Mohammad, Aladdi ...
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Jonsson, Andreas ...
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Dahlqvist, Johan ...
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visa fler...
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Stegmayr, Bernd, ...
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Johansson, Ingeg ...
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Rantapää-Dahlqvi ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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- Artiklar i publikationen
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Microorganisms
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Umeå universitet
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Lunds universitet