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Sökning: (WFRF:(Truong Therese)) > (2020-2024) > Cigarette Smoking a...

  • Dimou, NikiNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)

Cigarette Smoking and Endometrial Cancer Risk : observational and Mendelian Randomization Analyses

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • American Association for Cancer Research,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-199386
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199386URI
  • https://doi.org/10.1158/1055-9965.EPI-21-1176DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses.METHODS: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined.RESULTS: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer.CONCLUSIONS: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. IMPACT: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Omiyale, WemimoClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Biessy, CarineNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Viallon, VivianNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • O'Mara, Tracy A.Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, QLD, Brisbane, Australia (författare)
  • Aglago, Elom K.Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Ardanaz, EvaNavarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain (författare)
  • Bergmann, Manuela M.German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany (författare)
  • Bondonno, Nicola P.Danish Cancer Society Research Center, Copenhagen, Denmark (författare)
  • Braaten, TonjeDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway (författare)
  • Colorado-Yohar, Sandra M.CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia (författare)
  • Crous-Bou, MartaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health. Boston, MA, United States (författare)
  • Dahm, Christina C.Department of Public Health, Aarhus University, Aarhus, Denmark (författare)
  • Fortner, Renée TDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Gram, Inger T.Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway (författare)
  • Harlid, Sophia,1978-Umeå universitet,Obstetrik och gynekologi(Swepub:umu)soha0105 (författare)
  • Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Idahl, Annika,1965-Umeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002 (författare)
  • Kvaskoff, MarinaUVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France (författare)
  • Nøst, Therese H.Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway (författare)
  • Overvad, KimDepartment of Public Health, Aarhus University, Aarhus, Denmark (författare)
  • Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy (författare)
  • Perez-Cornago, AuroraCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Sacerdote, CarlottaUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy (författare)
  • Sánchez, Maria-JoseEscuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain (författare)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany (författare)
  • Severi, GianlucaUVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France; Department of Statistics, Computer Science, Applications "G. Parenti", University of Florence, Florence, Italy (författare)
  • Simeon, VittorioDipartimento di Salute Mentale e Fisica e Medicina Preventiva, University of Naples "L. Vanvitelli", Naples, Italy (författare)
  • Tagliabue, GiovannaDepartment of Research, Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian 1, Milan, Italy (författare)
  • Tjønneland, AnneDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark (författare)
  • Truong, ThérèseUVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France (författare)
  • Tumino, RosarioHyblean Association for Epidemiological Research, Ragusa, Italy (författare)
  • Johansson, MattiasSection of Genetics, International Agency for Research on Cancer, Lyon, France (författare)
  • Weiderpass, ElisabeteOffice of the Director, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Murphy, NeilNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Gunter, Marc J.Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Lacey, BenClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Allen, Naomi E.Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Dossus, LaureNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, FranceClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Epidemiology, Biomarkers and Prevention: American Association for Cancer Research31:9, s. 1839-18481055-99651538-7755

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