Sökning: WFRF:(Fortner Renée T.) >
Causal effects of l...
-
Dimou, NikiSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
(författare)
Causal effects of lifetime smoking on breast and colorectal cancer risk: Mendelian randomization study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
-
American Association for Cancer Research (AACR),2021
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:umu-183523
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-183523URI
-
https://doi.org/10.1158/1055-9965.EPI-20-1218DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Background: Observational evidence has shown that smoking is a risk factor for breast and colorectal cancer. We used Mendelian randomization (MR) to examine causal associations between smoking and risks of breast and colorectal cancer.Methods: Genome-Wide Association Study summary data were used to identify genetic variants associated with lifetime amount of smoking (n ¼ 126 variants) and ever having smoked regularly (n ¼ 112 variants). Using two-sample MR, we examined these variants in relation to incident breast (122,977 cases/ 105,974 controls) and colorectal cancer (52,775 cases/45,940 controls).Results: In inverse-variance weighted models, a genetic predisposition to higher lifetime amount of smoking was positively associated with breast cancer risk [OR per 1-SD increment: 1.13; 95% confidence interval (CI): 1.00–1.26; P ¼ 0.04]; although heterogeneity was observed. Similar associations were found for estrogen receptor–positive and estrogen receptor–negative tumors. Higher lifetime amount of smoking was positively associated with colorectal cancer (OR per 1-SD increment, 1.21; 95% CI, 1.04–1.40; P ¼ 0.01), colon cancer (OR, 1.31; 95% CI, 1.11–1.55; P < 0.01), and rectal cancer (OR, 1.36; 95% CI, 1.07–1.73; P ¼ 0.01). Ever having smoked regularly was not associated with risks of breast (OR, 1.01; 95% CI, 0.90–1.14; P ¼ 0.85) or colorectal cancer (OR, 0.97; 95% CI, 0.86–1.10; P ¼ 0.68).Conclusions: These findings are consistent with prior observational evidence and support a causal role of higher lifetime smoking amount in the development of breast and colorectal cancer.Impact: The results from this comprehensive MR analysis indicate that lifetime smoking is a causal risk factor for these common malignancies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Yarmolinsky, JamesDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
(författare)
-
Bouras, EmmanouilLaboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, Department of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
(författare)
-
Tsilidis, Konstantinos K.Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
(författare)
-
Martin, Richard M.Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; National Institute for Health Research (NIHR), Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, United Kingdom
(författare)
-
Lewis, Sarah J.Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
(författare)
-
Gram, Inger T.Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
(författare)
-
Bakker, Marije F.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University Utrecht, Utrecht, Netherlands
(författare)
-
Brenner, HermannDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
-
Figueiredo, Jane C.Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
(författare)
-
Fortner, Renee T.Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
-
Gruber, Stephen B.Center for Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States
(författare)
-
van Guelpen, BethanyUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99
(författare)
-
Hsu, LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
(författare)
-
Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Center for Lung Research (DZL), Translational Lung Research Center (TLRC), Heidelberg, Germany
(författare)
-
Kweon, Sun-SeogDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea
(författare)
-
Lin, YiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
-
Lindor, Noralane M.Department of Health Science Research, Mayo Clinic, AZ, Scottsdale, United States
(författare)
-
Newcomb, Polly A.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States
(författare)
-
Sanchez, Maria-JoseEscuela Andaluza de Salud Publica (EASP), Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigacion Biomedica en Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
(författare)
-
Severi, GianlucaCESP UMR1018, Universite Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science and Applications “G. Parenti”, University of Florence, Florence, Italy
(författare)
-
Tindle, Hilary A.General Internal Medicine, Vanderbilt University Medical Center, Vanderbilt University, TN, Nashville, United States
(författare)
-
Tumino, RosarioCancer Registry and Histopathology Department, Provincial Health Authority (ASP 7) Ragusa, Ragusa, Italy
(författare)
-
Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
-
Gunter, Marc J.Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
(författare)
-
Murphy, NeilSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
(författare)
-
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, FranceDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Cancer Epidemiology, Biomarkers and Prevention: American Association for Cancer Research (AACR)30:5, s. 953-9641055-99651538-7755
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Dimou, Niki
-
Yarmolinsky, Jam ...
-
Bouras, Emmanoui ...
-
Tsilidis, Konsta ...
-
Martin, Richard ...
-
Lewis, Sarah J.
-
visa fler...
-
Gram, Inger T.
-
Bakker, Marije F ...
-
Brenner, Hermann
-
Figueiredo, Jane ...
-
Fortner, Renee T ...
-
Gruber, Stephen ...
-
van Guelpen, Bet ...
-
Hsu, Li
-
Kaaks, Rudolf
-
Kweon, Sun-Seog
-
Lin, Yi
-
Lindor, Noralane ...
-
Newcomb, Polly A ...
-
Sanchez, Maria-J ...
-
Severi, Gianluca
-
Tindle, Hilary A ...
-
Tumino, Rosario
-
Weiderpass, Elis ...
-
Gunter, Marc J.
-
Murphy, Neil
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Cancer Epidemiol ...
- Av lärosätet
-
Umeå universitet