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Genome-wide interac...
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Li, YafangInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
(författare)
Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-02-09
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Oxford University Press,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-199395
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199395URI
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https://doi.org/10.1093/hmg/ddac030DOI
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https://lup.lub.lu.se/record/7919beac-6557-451e-8669-bd9f2f0ea8f5URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency < 0.05), rs17662871 [odds ratio (OR) = 0.71, P = 4.29×10-8); rs79942605 (OR = 2.17, P = 2.81×10-8) and rs208908 (OR = 0.70, P = 4.54×10-8) were identified with different risk effect of lung cancer between men and women. Further expression quantitative trait loci and functional annotation analysis suggested rs208908 affects lung cancer risk through differential regulation of Coxsackie virus and adenovirus receptor gene expression in lung tissues between men and women. Our study is one of the first studies to provide novel insights about the genetic and molecular basis for sex disparity in lung cancer development.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Xiao, XiangjunInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States
(författare)
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Li, JianrongInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States
(författare)
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Byun, JinyoungInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States
(författare)
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Cheng, ChaoInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
(författare)
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Bossé, YohanInstitut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Canada
(författare)
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McKay, JamesSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Albanes, DemetriosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States
(författare)
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Lam, StephenDepartment of Integrative Oncology, University of British Columbia, Vancouver, Canada
(författare)
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Tardon, AdoninaPublic Health Department, University of Oviedo, Asturias, Spain
(författare)
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Chen, ChuProgram in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
(författare)
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Bojesen, Stig E.Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2177, Denmark
(författare)
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Landi, Maria T.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States
(författare)
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Johansson, MattiasSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Risch, AngelaThoraxklinik at University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany; University of Salzburg and Cancer Cluster Salzburg, Austria
(författare)
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Bickeböller, HeikeDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Germany
(författare)
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Wichmann, H-ErichInstitute of Medical Statistics and Epidemiology, Technical University Munich, Germany
(författare)
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Christiani, David C.Departments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health, Boston, United States
(författare)
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Rennert, GadClalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
(författare)
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Arnold, SusanneUniversity of Kentucky, Markey Cancer Center, KY, Lexington, United States
(författare)
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Goodman, GarySwedish Cancer Institute, Seattle, WA 98104, USA
(författare)
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Field, John K.Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
(författare)
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Davies, Michael P AInstitute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
(författare)
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Shete, Sanjay S.Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, United States; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, United States
(författare)
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Le Marchand, LoicEpidemiology Program, University of Hawaii Cancer Center, Honolulu, United States
(författare)
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Melander, O.Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(författare)
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Brunnström, H.Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-hsb
(författare)
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Liu, GeoffreyUniversity Health Network- The Princess Margaret Cancer Centre, Toronto, Canada
(författare)
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Hung, Rayjean J.Luenfeld-Tanenbaum Research Institute, Sinai Health System, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Canada
(författare)
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Andrew, Angeline S.Departments of Epidemiology and Community and Family Medicine, Dartmouth College, Hanover, United States
(författare)
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Kiemeney, Lambertus A.Radboud University Medical Center, Nijmegen, Netherlands
(författare)
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Shen, HongbingDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China
(författare)
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Sun, RyanDepartment of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, United States
(författare)
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Zienolddiny, ShanNational Institute of Occupational Health, Oslo, Norway
(författare)
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Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002
(författare)
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Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025
(författare)
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Caporaso, NeilDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States
(författare)
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Teare, Dawn M.Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
(författare)
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Hong, Yun-ChulDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
(författare)
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Lazarus, PhilipDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States
(författare)
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Schabath, Matthew B.Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States
(författare)
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Aldrich, Melinda C.Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center Nashville, United States
(författare)
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Schwartz, Ann G.Department of Oncology, Wayne State University School of Medicine, Detroit, United States; Karmanos Cancer Institute, Detroit, United States
(författare)
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Gorlov, IvanInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
(författare)
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Purrington, KristenKarmanos Cancer Institute, Detroit, United States
(författare)
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Yang, PingDivision of Epidemiology, Department of Health Sciences Research, MN, United States
(författare)
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Liu, YanhongSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
(författare)
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Han, YounghunInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States
(författare)
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Bailey-Wilson, Joan E.National Human Genome Research Institute, NIH, Baltimore, United States
(författare)
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Pinney, Susan M.University of Cincinnati College of Medicine, Cincinnati, United States
(författare)
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Mandal, DiptasriLouisiana State University Health Sciences Center, New Orleans, United States
(författare)
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Willey, James C.College of Medicine and Life Sciences, University of Toledo, Toledo, United States
(författare)
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Gaba, ColetteUniversity of Toledo College of Medicine, Toledo, United States
(författare)
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Brennan, PaulSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Amos, Christopher I.Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
(författare)
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Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United StatesInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States
(creator_code:org_t)
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et al.
Sammanhörande titlar
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Ingår i:Human Molecular Genetics: Oxford University Press31:16, s. 2831-28430964-69061460-2083
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Till lärosätets databas
- Av författaren/redakt...
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Li, Yafang
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Xiao, Xiangjun
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Li, Jianrong
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Byun, Jinyoung
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Cheng, Chao
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Bossé, Yohan
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visa fler...
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McKay, James
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Albanes, Demetri ...
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Lam, Stephen
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Tardon, Adonina
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Chen, Chu
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Bojesen, Stig E.
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Landi, Maria T.
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Johansson, Matti ...
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Risch, Angela
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Bickeböller, Hei ...
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Wichmann, H-Eric ...
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Christiani, Davi ...
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Rennert, Gad
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Arnold, Susanne
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Goodman, Gary
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Field, John K.
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Davies, Michael ...
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Shete, Sanjay S.
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Le Marchand, Loi ...
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Melander, O.
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Brunnström, H.
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Liu, Geoffrey
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Hung, Rayjean J.
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Andrew, Angeline ...
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Kiemeney, Lamber ...
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Shen, Hongbing
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Sun, Ryan
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Zienolddiny, Sha ...
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Grankvist, Kjell
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Johansson, Mikae ...
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Caporaso, Neil
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Teare, Dawn M.
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Hong, Yun-Chul
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Lazarus, Philip
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Schabath, Matthe ...
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Aldrich, Melinda ...
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Schwartz, Ann G.
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Gorlov, Ivan
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Purrington, Kris ...
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Yang, Ping
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Liu, Yanhong
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Han, Younghun
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Bailey-Wilson, J ...
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Pinney, Susan M.
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Mandal, Diptasri
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Willey, James C.
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Gaba, Colette
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Brennan, Paul
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Amos, Christophe ...
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