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  • Fortuin-de Smidt, Melony C.Umeå University,Umeå universitet,Allmänmedicin (author)

Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors : EPIC-CVD case-cohort study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-04-11
  • Oxford University Press (OUP),2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-199406
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199406URI
  • https://doi.org/10.1093/eurjpc/zwac055DOI
  • https://lup.lub.lu.se/record/d16c5bf4-bac3-47bd-81b3-0c5e1a176d1aURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149307971URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • AIMS: This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors.METHODS AND RESULTS: EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal).Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32-64%] and 21% (95%CI 2-44%), with hypercholesterolaemia were 80% (95%CI 55-108%) and 48% (95%CI 22-81%), with hypertension were 80% (95%CI 65-96%) and 49% (95%CI 28-74%), with diabetes were 142% (95%CI 63-260%), and 100% (95%CI 32-204%), and amongst smokers were 152% (95%CI 122-186%) and 109% (95%CI 74-150%).CONCLUSIONS: In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sewe, Maquins OdhiamboUmeå University,Umeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)odse0001 (author)
  • Lassale, CamilleHospital del Mar Medical Research Institute,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN) (author)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization (author)
  • Andersson, Jonas,1977-Umeå University,Umeå universitet,Avdelningen för medicin,Skellefteå Research Unit(Swepub:umu)jasaon96 (author)
  • Huerta, José MaríaCIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council (author)
  • Ekelund, UlfNorwegian School of Sport Sciences,Norwegian Institute of Public Health (author)
  • Aleksandrova, KrasimiraLeibniz Institute for Prevention Research and Epidemiology - BIPS GmbH,University of Bremen (author)
  • Tong, Tammy Y.N.University of Oxford (author)
  • Dahm, Christina C.Aarhus University (author)
  • Tjønneland, AnneUniversity of Copenhagen,Danish Cancer Society (author)
  • Kyrø, CecilieDanish Cancer Society (author)
  • Steindorf, KarenGerman Cancer Research Centre (author)
  • Schulze, Matthias B.University of Potsdam,German Institute of Human Nutrition (author)
  • Katzke, VerenaGerman Cancer Research Centre (author)
  • Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin (author)
  • Agnoli, ClaudiaIstituto Nazionale dei Tumori (author)
  • Masala, GiovannaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (author)
  • Tumino, Rosario (author)
  • Panico, SalvatoreUniversity of Naples Federico II (author)
  • Boer, Jolanda M.A.National Institute for Public Health and the Environment (RIVM),Catalan Institute of Oncology,Bellvitge Biomedical Research Institute (author)
  • Onland-Moret, N. CharlotteUniversity Medical Center Utrecht (author)
  • Wendel-Vos, G.C. WandaNational Institute for Public Health and the Environment (RIVM) (author)
  • van der Schouw, Yvonne T.University Medical Center Utrecht (author)
  • Benjaminsen Borch, KristinUiT The Arctic University of Norway, Tromsø (author)
  • Agudo, Antonio (author)
  • Petrova, DafinaAndalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP) (author)
  • Chirlaque, María-DoloresMurcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP) (author)
  • Conchi, Moreno-IribasHealth Research Institute of Navarra (IDISNA) (author)
  • Amiano, PilarCIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute (author)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ome (author)
  • Heath, Alicia K.Imperial College London (author)
  • Aune, DagfinnKarolinska Institute,Imperial College London,Oslo university hospital (author)
  • Forouhi, Nita G.University of Cambridge (author)
  • Langenberg, ClaudiaBerlin Institute of Health (BIH),University of Cambridge (author)
  • Brage, SorenUniversity of Cambridge (author)
  • Riboli, ElioImperial College London (author)
  • Wareham, Nicholas J.University of Cambridge (author)
  • Danesh, JohnWellcome Trust Sanger Institute,University of Cambridge (author)
  • Butterworth, Adam S.University of Cambridge (author)
  • Wennberg, Patrik,1972-Umeå University,Umeå universitet,Allmänmedicin(Swepub:umu)pawe0002 (author)
  • Umeå universitetAllmänmedicin (creator_code:org_t)

Related titles

  • In:European Journal of Preventive Cardiology: Oxford University Press (OUP)29:12, s. 1618-16292047-48732047-4881

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