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Associations of dep...
Associations of depression and regional brain structure across the adult lifespan : Pooled analyses of six population-based and two clinical cohort studies in the European Lifebrain consortium
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- Binnewies, Julia (författare)
- Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Netherlands
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- Nawijn, Laura (författare)
- Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Netherlands
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- Brandmaier, Andreas M. (författare)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Department of Psychology, MSB Medical School Berlin, Berlin, Germany
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- Baaré, William F.C. (författare)
- Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark
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- Bartrés-Faz, David (författare)
- Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona and Institut de Neurociències, Universitat de Barcelona, Spain
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- Drevon, Christian A. (författare)
- Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo & Vitas Ltd, Oslo Science Park, Oslo, Norway
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- Düzel, Sandra (författare)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
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- Fjell, Anders M. (författare)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Norway
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- Han, Laura K.M. (författare)
- Centre for Youth Mental Health, The University of Melbourne, VIC, Parkville, Australia
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- Knights, Ethan (författare)
- MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom
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- Lindenberger, Ulman (författare)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
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- Milaneschi, Yuri (författare)
- Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Netherlands
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- Mowinckel, Athanasia M. (författare)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper
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- Plachti, Anna (författare)
- Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark
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- Madsen, Kathrine Skak (författare)
- Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark; Radiography, Department of Technology, University College Copenhagen, Copenhagen, Denmark
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- Solé-Padullés, Cristina (författare)
- Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona and Institut de Neurociències, Universitat de Barcelona, Spain
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- Suri, Sana (författare)
- Wellcome Centre for Integrative Neuroimaging, University of Oxford, United Kingdom; Department of Psychiatry, University of Oxford, United Kingdom
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- Walhovd, Kristine B. (författare)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Norway
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- Zsoldos, Enikő (författare)
- Wellcome Centre for Integrative Neuroimaging, University of Oxford, United Kingdom; Department of Psychiatry, University of Oxford, United Kingdom
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- Ebmeier, Klaus P. (författare)
- Department of Psychiatry, University of Oxford, United Kingdom
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- Penninx, Brenda W.J.H. (författare)
- Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Netherlands
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: NeuroImage. - : Elsevier. - 2213-1582. ; 36
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Major depressive disorder has been associated with lower prefrontal thickness and hippocampal volume, but it is unknown whether this association also holds for depressive symptoms in the general population. We investigated associations of depressive symptoms and depression status with brain structures across population-based and patient-control cohorts, and explored whether these associations are similar over the lifespan and across sexes.Methods: We included 3,447 participants aged 18–89 years from six population-based and two clinical patient-control cohorts of the European Lifebrain consortium. Cross-sectional meta-analyses using individual person data were performed for associations of depressive symptoms and depression status with FreeSurfer-derived thickness of bilateral rostral anterior cingulate cortex (rACC) and medial orbitofrontal cortex (mOFC), and hippocampal and total grey matter volume (GMV), separately for population-based and clinical cohorts.Results: Across patient-control cohorts, depressive symptoms and presence of mild-to-severe depression were associated with lower mOFC thickness (rsymptoms = −0.15/ rstatus = −0.22), rACC thickness (rsymptoms = −0.20/ rstatus = −0.25), hippocampal volume (rsymptoms = −0.13/ rstatus = 0.13) and total GMV (rsymptoms = −0.21/ rstatus = −0.25). Effect sizes were slightly larger for presence of moderate-to-severe depression. Associations were similar across age groups and sex. Across population-based cohorts, no associations between depression and brain structures were observed.Conclusions: Fitting with previous meta-analyses, depressive symptoms and depression status were associated with lower mOFC, rACC thickness, and hippocampal and total grey matter volume in clinical patient-control cohorts, although effect sizes were small. The absence of consistent associations in population-based cohorts with mostly mild depressive symptoms, suggests that significantly lower thickness and volume of the studied brain structures are only detectable in clinical populations with more severe depressive symptoms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Brain structure
- Depressive symptoms
- Grey matter
- Lifespan
- Meta-analysis
- Neuroimaging
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Binnewies, Julia
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Nawijn, Laura
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Brandmaier, Andr ...
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Baaré, William F ...
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Bartrés-Faz, Dav ...
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Drevon, Christia ...
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Düzel, Sandra
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Fjell, Anders M.
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Han, Laura K.M.
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Knights, Ethan
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Lindenberger, Ul ...
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Milaneschi, Yuri
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Mowinckel, Athan ...
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Nyberg, Lars, 19 ...
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Plachti, Anna
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Madsen, Kathrine ...
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Solé-Padullés, C ...
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Suri, Sana
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Walhovd, Kristin ...
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Zsoldos, Enikő
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Ebmeier, Klaus P ...
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Penninx, Brenda ...
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