Feasibility and reliability of measures of bioactive lipids in human plasma and nasal mucosa

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MARC

Claeson, Anna-Sara,1974-Umeå universitet,Institutionen för psykologi (author)

Feasibility and reliability of measures of bioactive lipids in human plasma and nasal mucosa

Article/chapterEnglish2022

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Elsevier,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-199602
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199602URI
https://doi.org/10.1016/j.jchromb.2022.123357DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Analysis of bioactive lipids is increasingly useful in clinical studies, and there is a need for non-invasive and easy-to-use sampling methods that meet the demands of reliability. Samples that can be taken by a non-professional and that can be taken repeatedly so as to provide more detailed information about the inflammatory process are often desired. In this study, the feasibility of non-invasive sampling of nasal mucosa and saliva for the analysis of bioactive lipid mediators (e.g. oxylipins and endocannabinoids) was evaluated in a pilot study (n = 10). In a second study, the reliability (relative and absolute) of sampling of these lipid mediators derived from nasal mucosa and from plasma was assessed by calculation of the intraclass correlation coefficient and Bland–Altman’s limit of agreement. Samples were taken at the same time of day on two occasions from a cohort of individuals with and without building-related intolerance (n = 37). Nasal mucosa proved to be a suitable matrix for the analysis of bioactive lipids and was therefore included in the study on reliability together with the plasma samples. Relative reliability varied among the identified oxylipins and endocannabinoids. Arachidonic acid derivatives showed generally better reliability. Absolute reliability measures also varied indicating that only a subset of the oxylipins and endocannabinoids were suitable as biomarkers in either nasal mucosa or plasma and should therefore be used with caution for that purpose.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Klinisk laboratoriemedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Clinical Laboratory Medicine hsv//eng
NATURVETENSKAP Kemi Analytisk kemi hsv//swe
NATURAL SCIENCES Chemical Sciences Analytical Chemistry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Oto-rhino-laryngologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Otorhinolaryngology hsv//eng
Nasal mucosa
Plasma
Oxylipins
Endocannabinoids
Feasibility
Reliability

Added entries (persons, corporate bodies, meetings, titles ...)

Lindberg, Richard H.Umeå universitet,Kemiska institutionen(Swepub:umu)rili0003 (author)
Gouveia-Figueira, Sandra (author)
Nording, Malin L.,1976-Umeå universitet,Kemiska institutionen(Swepub:umu)mano0003 (author)
Umeå universitetInstitutionen för psykologi (creator_code:org_t)

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In:Journal of chromatography. B: Elsevier12061570-02321873-376X

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Clinical Laborat ...

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Analytical Chemi ...

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