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Real-world Treatmen...
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Bjartell, AndersLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
(author)
Real-world Treatment Sequencing in Patients with Metastatic Castration-resistant Prostate Cancer: Results from the Prospective, International, Observational Prostate Cancer Registry
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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Elsevier,2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-199833
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199833URI
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https://doi.org/10.1016/j.euros.2022.08.018DOI
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https://lup.lub.lu.se/record/584e9dd4-9a9d-4af2-8c37-2674f5fe9d16URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Prostate cancer has a multifaceted treatment pattern. Evidence is lacking for optimal treatment sequences for metastatic castration-resistant prostate cancer (mCRPC).Objective: To increase the understanding of real-world treatment pathways and outcomes in patients with mCRPC.Design, setting, and participants: A prospective, noninterventional, real-world analysis of 3003 patients with mCRPC in the Prostate Cancer Registry (PCR; NCT02236637) from June 14, 2013 to July 9, 2018 was conducted.Intervention: Patients received first- and second-line hormonal treatment and chemotherapy as follows: abiraterone acetate plus prednisone (abiraterone)-docetaxel (ABI-DOCE), abiraterone-enzalutamide (ABI-ENZA), abiraterone–radium-223 (ABI-RAD), docetaxel-abiraterone (DOCE-ABI), docetaxel-cabazitaxel (DOCE-CABA), docetaxel-enzalutamide (DOCE-ENZA), and enzalutamide-docetaxel (ENZA-DOCE).Outcome measurements and statistical analysis: Baseline patient characteristics, quality of life, mCRPC treatments, and efficacy outcomes (progression and survival) were presented descriptively.Results and limitations: Data from 727 patients were eligible for the analysis (ABI-DOCE n = 178, ABI-ENZA n = 99, ABI-RAD n = 27, DOCE-ABI n = 191, DOCE-CABA n = 74, DOCE-ENZA n = 116, and ENZA-DOCE n = 42). Demographics and disease characteristics among patients between different sequences varied greatly. Most patients who started on abiraterone or enzalutamide stopped therapy because of disease progression. No randomisation to allow treatment/sequence comparisons limited this observational study.Conclusions: The real-world PCR data complement clinical trial data, reflecting more highly selected patient populations than seen in routine clinical practice. Baseline characteristics play a role in mCRPC first-line treatment selection, but other factors, such as treatment availability, have an impact. Efficacy observations are limited and should be interpreted with caution.Patient summary: Baseline characteristics appear to have a role in the first-line treatment selection of metastatic castration-resistant prostate cancer in the real-world setting. First-line abiraterone acetate plus prednisone seems to be the preferred treatment option for older patients and those with lower Gleason scores, first-line docetaxel for younger patients and those with more advanced disease, and first-line enzalutamide for patients with fewer metastases and more favourable performance status. The benefit to patients from these observations remains unknown.
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Costa, LuisOncology Division, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal; Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal,University of Lisbon
(author)
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Kramer, GeroDepartment of Urology, Medical University of Vienna, Vienna, Austria
(author)
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Zurawski, BogdanCentrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy, Dzial Onkologii Klinicznej, Ambulatorium Chemioterapii, Bydgoszcz, Poland
(author)
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Galli, LucaPisana University Hospital, Pisa, Italy,University Hospital of Pisa
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Werbrouck, PatrickAZ Groeninge, Kortrijk, Belgium,Algemeen Ziekenhuis Groeninge
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Ecke, ThorstenHelios Klinikum Bad Saarow, Bad Saarow, Germany
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Parikh, OmiRoyal Blackburn Hospital, Blackburn, United Kingdom
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Bennamoun, MostefaInstitut Mutualiste Montsouris, Paris, France
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Garcia Freire, CamiloHospital Clínico Universitario de Santiago, Servicio de Urología, Santiago de Compostela, Spain,Complejo Hospitalario Universitario de Santiago
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Peer, AvivitRambam Medical Center, Haifa, Israel
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Ljungberg, Börje,Professor,1949-Umeå University,Umeå universitet,Urologi och andrologi(Swepub:umu)bolj0001
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Cicin, IrfanTrakya University Hospital, Medical Oncology Department, Edirne, Turkey
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Smith, EmmaJanssen-Cilag, High Wycombe, United Kingdom
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Lukac, MartinParexel International Czech Republic sro, on behalf of Janssen Pharmaceutica NV, Beerse, Belgium
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Wapenaar, RobertJanssen-Cilag BV, Breda, Netherlands
(author)
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Chowdhury, SimonGuy's and St Thomas’ NHS Foundation Trust and Sarah Cannon Research Institute, London, United Kingdom
(author)
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Avdelningen för translationell cancerforskningInstitutionen för laboratoriemedicin
(creator_code:org_t)
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In:European Urology Open Science: Elsevier45, s. 12-222666-16912666-1683
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Bjartell, Anders
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Costa, Luis
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Kramer, Gero
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Zurawski, Bogdan
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Galli, Luca
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Ecke, Thorsten
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Parikh, Omi
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Peer, Avivit
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Cicin, Irfan
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Smith, Emma
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Lukac, Martin
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Chowdhury, Simon
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