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Recurrence pattern ...
Recurrence pattern in localized RCC : results from a European multicenter database (RECUR)
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- Fallara, Giuseppe (författare)
- Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy,San Raffaele Hospital
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- Larcher, Alessandro (författare)
- Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy,San Raffaele Hospital
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- Dabestani, Saeed (författare)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urologi,Urological cancer, Malmö,Lund University Research Groups,Urology,Central Hospital Kristianstad
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- Fossati, Nicola (författare)
- Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy,San Raffaele Hospital
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- Järvinen, Petrus (författare)
- Abdominal Center, Urology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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- Nisen, Harry (författare)
- Abdominal Center, Urology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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- Gudmundsson, Eirikur (författare)
- Department of Urology, Landspitali University Hospital, Reykjavik, Iceland,National University Hospital of Iceland
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- Lam, Thomas B. (författare)
- Academic Urology Unit, University of Aberdeen, Aberdeen, United Kingdom
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- Marconi, Lorenzo (författare)
- Department of Urology, Coimbra University Hospital, Coimbra, Portugal
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- Fernandéz-Pello, Sergio (författare)
- Department of Urology, Cabueñes University Hospital, Gijón, Spain
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- Meijer, Richard P. (författare)
- Department of Oncological Urology, University Medical Centre Utrecht, Utrecht, Netherlands
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- Volpe, Alessandro (författare)
- Department of Urology, University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy
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- Beisland, Christian (författare)
- Department of Urology, Haukeland University Hospital, Norway and Department of Clinical Medicine, University of Bergen, Bergen, Norway
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- Klatte, Tobias (författare)
- Department of Surgery, University of Cambridge, Cambridge, United Kingdom; Department of Urology, The Royal Bournemouth Hospital, University Hospitals Dorset NHS Foundation Trust, Bournemouth, United Kingdom
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- Stewart, Grant D. (författare)
- Department of Surgery, University of Cambridge, Cambridge, United Kingdom
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- Bensalah, Karim (författare)
- Department of Urology, University of Rennes, Rennes, France
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- Ljungberg, Börje, Professor, 1949- (författare)
- Umeå University,Umeå universitet,Urologi och andrologi
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- Bertini, Roberto (författare)
- Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy,San Raffaele Hospital
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- Montorsi, Francesco (författare)
- Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy,San Raffaele Hospital
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- Bex, Axel (författare)
- Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, UCL Division of Surgical and Interventional Science, London, United Kingdom; Department of Urology, Netherlands Cancer Institute, Amsterdam, Netherlands,University College London
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- Capitanio, Umberto (författare)
- Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy,San Raffaele Hospital
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Urologic Oncology. - : Elsevier. - 1078-1439 .- 1873-2496. ; 40:11, s. 494.e11-494.e17
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Introduction: The impact of open versus minimally invasive surgery on recurrence pattern in the management of localized renal cell carcinoma (RCC) remains uncertain. We thus aimed to determine the impact of surgical approach on survival and recurrence pattern.Material and methods: This is a multi-institutional, matched cohort study on patients with pT1-3aN0M0 RCC from the RECUR database. After propensity score matching between open and minimally invasive surgery, disease-free (DFS) survival and risk of first recurrence according to recurrence site, namely local recurrence, abdominal/retroperitoneal, thoracic/mediastinal or uncommon site metastases were investigated with Cox regression analysis. Overall (OS) and Cancer Specific Survival (CSS) were also assessed.Results: After matching, 1,019 patients who underwent open and 1,019 who underwent minimally invasive surgery were included (of which 70 robot-assisted). At 5.2 years of median follow-up, 130 patients in open and 125 in minimally invasive group experienced disease progression. A higher risk of local recurrence (HR 2.06; 95% CI 1.18–3.58, P-value = 0.01) and uncommon site metastases (HR 1.09; 95% CI 1.01–1.16; P-value = .04) was found for minimally invasive surgery relative to open surgery, while no difference was found in terms of DFS (HR 0.83; 95% CI 0.64–1.06; P-value = .14). No differences were found in terms of OS and CSS. Main limitation is the retrospective nature of the study.Conclusions: The risk for local recurrence and uncommon site metastases was higher for minimally invasive surgery compared to open surgery, although no differences were found for OS, CSS, and DFS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Disease free survival
- Local recurrence
- Minimally invasive surgery
- Renal cancer
- Uncommon sites metastasis
- Disease free survival
- Local recurrence
- Minimally invasive surgery
- Renal cancer
- Uncommon sites metastasis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Fallara, Giusepp ...
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Larcher, Alessan ...
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Dabestani, Saeed
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Fossati, Nicola
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Järvinen, Petrus
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Nisen, Harry
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Gudmundsson, Eir ...
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Lam, Thomas B.
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Marconi, Lorenzo
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Fernandéz-Pello, ...
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Meijer, Richard ...
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Volpe, Alessandr ...
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Beisland, Christ ...
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Klatte, Tobias
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Stewart, Grant D ...
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Bensalah, Karim
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Ljungberg, Börje ...
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Bertini, Roberto
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Montorsi, France ...
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Bex, Axel
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Capitanio, Umber ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Urologic Oncolog ...
- Av lärosätet
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Umeå universitet
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Lunds universitet