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Search: WFRF:(Jensen Steen M.) > (2015-2019) > Idiopathic ventricu...

  • Chaudhry, U.Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine (author)

Idiopathic ventricular fibrillation – Long term prognosis in relation to clinical findings and ECG patterns in a Swedish cohort

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • Philadephia :Churchill Livingstone Inc. Medical Publishers,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-200287
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200287URI
  • https://doi.org/10.1016/j.jelectrocard.2019.06.016DOI
  • https://lup.lub.lu.se/record/d11e84ab-83e5-4425-b02f-43e2c76f6b30URI
  • https://gup.ub.gu.se/publication/282146URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Idiopathic ventricular fibrillation (IVF) is a rare cause of sudden cardiac arrest which may pose therapeutic and prognostic challenges. To date, the only effective treatment for survivors of cardiac arrest is the insertion of an implantable cardioverter-defibrillator (ICD). We sought to review the long-term outcome of a Swedish cohort with IVF.Methods and results: Fifty patients with IVF diagnosis between 1988 and 2016 (mean age at index 34.3, 56% male), were followed for a median 13.8 years in this retrospective multicenter observational study. No cardiac mortality was reported. 32% (n = 16) of patients had recurrence of ventricular fibrillation or sustained ventricular tachycardia, requiring ICD therapy, at a median time of 1.9 years (range 0.1–20.3) from the index event. Annual incidence rate of ventricular tachyarrhythmia was 3.1%. Abnormal ECG at baseline did not predict appropriate ICD therapy (p = 0.56). During the follow-up period, 14% (n = 7) patients received a cardiac diagnosis. Follow-up genetic testing was low (26%), however did confirm pathogenic mutations in three cases.Conclusion: Idiopathic VF is a rare diagnosis with a relatively good prognosis provided ICD therapy is initiated. Routine clinical follow-up is recommended due to potential late emerging cardiac pathology. ECG changes are common, but have no prognostic value in determining the risk of ventricular arrhythmias recurrence. Screening for genetic diseases has previously been low, and this calls for improvement, especially since cheaper and more comprehensive genetic panels are now readily available.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Platonov, P. G.Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)kard-ppl (author)
  • Rubulis, Aigars,1974Region Västra Götaland, Sahlgrenska University Hospital, Department of Cardiology, Gothenburg, Sweden(Swepub:gu)xrubai (author)
  • Bergfeldt, Lennart,1950Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbleny (author)
  • Jensen, Steen M.Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)stje0001 (author)
  • Lundin, C.Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetiska och epigenetiska studier av barnleukemi,Forskargrupper vid Lunds universitet,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Genetic and epigenetic studies of pediatric leukemia,Lund University Research Groups(Swepub:lu)klin-clu (author)
  • Borgquist, R.Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Aarhus University Hospital(Swepub:lu)medf-rbo (author)
  • SM, Lundin (author)
  • KardiologiSektion II (creator_code:org_t)

Related titles

  • In:Journal of ElectrocardiologyPhiladephia : Churchill Livingstone Inc. Medical Publishers56, s. 46-510022-07361532-8430

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