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Sökning: (AMNE:(MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området)) pers:(Uhlin Bernt Eric) > (2020-2024) > Emergence of high c...

  • Ahsan, UmairaInstitute of Biomedical and Allied Health Sciences, University of Health Sciences, Lahore, Pakistan; Department of Microbiology, University of Health Sciences, Lahore, Pakistan (författare)

Emergence of high colistin resistance in carbapenem resistant Acinetobacter baumannii in Pakistan and its potential management through immunomodulatory effect of an extract from Saussurea lappa

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-09-16
  • Frontiers Media S.A.2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-200374
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200374URI
  • https://doi.org/10.3389/fphar.2022.986802DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Carbapenem resistant Acinetobacter baumannii has emerged as one of the most difficult to treat nosocomial bacterial infections in recent years. It was one of the major causes of secondary infections in Covid-19 patients in developing countries. The polycationic polypeptide antibiotic colistin is used as a last resort drug to treat carbapenem resistant A. baumannii infections. Therefore, resistance to colistin is considered as a serious medical threat. The purpose of this study was to assess the current status of colistin resistance in Pakistan, a country where carbapenem resistant A. bumannii infections are endemic, to understand the impact of colistin resistance on virulence in mice and to assess alternative strategies to treat such infections. Out of 150 isolates collected from five hospitals in Pakistan during 2019–20, 84% were carbapenem resistant and 7.3% were additionally resistant to colistin. There were two isolates resistant to all tested antibiotics and 83% of colistin resistant isolates were susceptible to only tetracycline family drugs doxycycline and minocycline. Doxycycline exhibited a synergetic bactericidal effect with colistin even in colistin resistant isolates. Exposure of A. baumannii 17978 to sub inhibitory concentrations of colistin identified novel point mutations associated with colistin resistance. Colistin tolerance acquired independent of mutations in lpxA, lpxB, lpxC, lpxD, and pmrAB supressed the proinflammatory immune response in epithelial cells and the virulence in a mouse infection model. Moreover, the oral administration of water extract of Saussuria lappa, although not showing antimicrobial activity against A. baumannii in vitro, lowered the number of colonizing bacteria in liver, spleen and lung of the mouse model and also lowered the levels of neutrophils and interleukin 8 in mice. Our findings suggest that the S. lappa extract exhibits an immunomodulatory effect with potential to reduce and cure systemic infections by both opaque and translucent colony variants of A. baumannii.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Mushtaq, FizzaInstitute of Biomedical and Allied Health Sciences, University of Health Sciences, Lahore, Pakistan (författare)
  • Saleem, SidrahDepartment of Microbiology, University of Health Sciences, Lahore, Pakistan (författare)
  • Malik, AbdulInstitute of Biomedical and Allied Health Sciences, University of Health Sciences, Lahore, Pakistan (författare)
  • Sarfaraz, HiraInstitute of Biomedical and Allied Health Sciences, University of Health Sciences, Lahore, Pakistan (författare)
  • Shahzad, MuhammadDepartment of Pharmacology, University of Health Sciences, Lahore, Pakistan (författare)
  • Uhlin, Bernt EricUmeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)beuh0001 (författare)
  • Ahmad, IrfanUmeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Institute of Biomedical and Allied Health Sciences, University of Health Sciences, Lahore, Pakistan(Swepub:umu)irah0007 (författare)
  • Institute of Biomedical and Allied Health Sciences, University of Health Sciences, Lahore, Pakistan; Department of Microbiology, University of Health Sciences, Lahore, PakistanInstitute of Biomedical and Allied Health Sciences, University of Health Sciences, Lahore, Pakistan (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Frontiers in Pharmacology: Frontiers Media S.A.131663-9812

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