Outcomes of cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after the acute phase

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MARC

Van De Munckhof, AnitaDepartment of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Netherlands (author)

Outcomes of cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after the acute phase

Article/chapterEnglish2022

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American Heart Association,2022
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LIBRIS-ID:oai:DiVA.org:umu-200400
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200400URI
https://doi.org/10.1161/STROKEAHA.122.039575DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Background: Cerebral venous thrombosis (CVT) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe condition, with high in-hospital mortality rates. Here, we report clinical outcomes of patients with CVT-VITT after SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccination who survived initial hospitalization.Methods: We used data from an international registry of patients who developed CVT within 28 days of SARS-CoV-2 vaccination, collected until February 10, 2022. VITT diagnosis was classified based on the Pavord criteria. Outcomes were mortality, functional independence (modified Rankin Scale score 0-2), VITT relapse, new thrombosis, and bleeding events (all after discharge from initial hospitalization).Results: Of 107 CVT-VITT cases, 43 (40%) died during initial hospitalization. Of the remaining 64 patients, follow-up data were available for 60 (94%) patients (37 definite VITT, 9 probable VITT, and 14 possible VITT). Median age was 40 years and 45/60 (75%) patients were women. Median follow-up time was 150 days (interquartile range, 94-194). Two patients died during follow-up (3% [95% CI, 1%-11%). Functional independence was achieved by 53/60 (88% [95% CI, 78%-94%]) patients. No new venous or arterial thrombotic events were reported. One patient developed a major bleeding during follow-up (fatal intracerebral bleed).Conclusions: In contrast to the high mortality of CVT-VITT in the acute phase, mortality among patients who survived the initial hospitalization was low, new thrombotic events did not occur, and bleeding events were rare. Approximately 9 out of 10 CVT-VITT patients who survived the acute phase were functionally independent at follow-up.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
hospitalization
intracranial thrombosis
mortality
thrombocytopenia
vaccination
venous thrombosis
Neurology
neurologi

Added entries (persons, corporate bodies, meetings, titles ...)

Lindgren, ErikDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden (author)
Kleinig, Timothy J.Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia (author)
Field, Thalia S.Division of Neurology, Vancouver Stroke Program, University of British Columbia, Vancouver, Canada (author)
Cordonnier, CharlotteUniversity Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience and Cognition, France (author)
Krzywicka, KatarzynaDepartment of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Netherlands (author)
Poli, SvenDepartment of Neurology and Stroke, University Hospital Tuebingen, Eberhard-Karls University, Germany; Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Germany (author)
Sánchez Van Kammen, MayteDepartment of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Netherlands (author)
Borhani-Haghighi, AfshinClinical Neurology Research Center, Shiraz University of Medical Sciences, Iran (author)
Lemmens, RobinDepartment of Neurology, University Hospitals Leuven, Belgium (author)
Scutelnic, AdrianDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (author)
Ciccone, AlfonsoDepartment of Neurology, Carlo Poma Hospital, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy (author)
Gattringer, ThomasDepartment of Neurology, Medical University of Graz, Austria (author)
Wittstock, MatthiasDepartment of Neurology, University Hospital Rostock, Germany (author)
Dizonno, VanessaDivision of Neurology, Vancouver Stroke Program, University of British Columbia, Vancouver, Canada (author)
Devroye, AnnemieDepartment of Neurology, University Hospitals Leuven, Belgium (author)
Elkady, AhmedDepartment of Neurology, Saudi German Hospital, Jeddah, Saudi Arabia (author)
Günther, AlbrechtDepartment of Neurology, Jena University Hospital, Germany (author)
Cervera, AlvaroRoyal Darwin Hospital, NT, Darwin, Australia (author)
Mengel, AnneroseDepartment of Neurology and Stroke, University Hospital Tuebingen, Eberhard-Karls University, Germany (author)
Chew, Beng Lim AlvinDepartment of Neurology, John Hunter Hospital, Newcastle, Australia (author)
Buck, BrianDivision of Neurology, University of Alberta Hospital, Edmonton, Canada (author)
Zanferrari, CarlaDepartment of Neurology, Azienda Ospedaliera di Melegnano e Della Martesana, Italy (author)
Garcia-Esperon, CarlosDepartment of Neurology, John Hunter Hospital, Newcastle, Australia (author)
Jacobi, ChristianDepartment of Neurology, Krankenhaus Nordwest, Frankfurt am Main, Germany (author)
Soriano, CristinaDepartment of Neurology, Hospital General de Castellón, Castelló, Spain (author)
Michalski, DominikDepartment of Neurology, Leipzig University Hospital, Germany (author)
Zamani, ZohrehDepartment of Neurology, Firoozabadi Hospital, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran (author)
Blacquiere, DylanDivision of Neurology, Ottawa Hospital, Canada (author)
Johansson, EliasUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Neurovetenskaper(Swepub:umu)elsjon02 (author)
Cuadrado-Godia, ElisaDepartment of Neurology, University Hospital del Mar, Barcelona, Spain (author)
Vuillier, FabriceStroke Unit, University Hospital of Besancon, France (author)
Bode, Felix J.Department of Neurology, Universitätsklinikum Bonn, Germany (author)
Caparros, FrançoisUniversity Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience and Cognition, France (author)
Maier, FrankDepartment of Neurology, Caritas Hospital Saarbrücken, Germany (author)
Tsivgoulis, GeorgiosSecond Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Greece (author)
Katzberg, Hans D.Department of Neuromuscular Medicine, Toronto General Hospital, Canada (author)
Duan, JiangangDepartment of Neurology and Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China (author)
Burrow, JimDepartment of Neurology, Royal Darwin Hospital, Tiwi, Australia (author)
Pelz, JohannDepartment of Neurology, Leipzig University Hospital, Germany (author)
Mbroh, JoshuaDepartment of Neurology and Stroke, University Hospital Tuebingen, Eberhard-Karls University, Germany; Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Germany (author)
Oen, JoyceDepartment of Neurology, Antonius Ziekenhuis, Sneek, Netherlands (author)
Schouten, JudithDepartment of Neurology, Rijnstate Hospital Arnhem, Netherlands (author)
Zimmermann, JulianDepartment of Neurology, Universitätsklinikum Bonn, Germany (author)
Ng, KarlDepartment of Neurology, Royal North Shore Hospital, Sydney, Australia (author)
Garambois, KatiaDepartment of Neurology, CHU Grenoble Alpes, France (author)
Petruzzellis, MarcoDepartment of Neurology, AOU Consorziale Policlinico di Bari, Italy (author)
Carvalho Dias, MarianaDepartment of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte, University of Lisbon, Portugal (author)
Ghiasian, MasoudDepartment of Neurology, Sina Hospital, Hamadan University of Medical Science, Iran (author)
Romoli, MicheleNeurology and Stroke Unit, Department of Neuroscience, Bufalini Hospital, Cesena, Italy (author)
Miranda, MiguelDepartment of Neurology, Hospital de Cascais Dr. José de Almeida, Cascais, Portugal (author)
Wronski, MiriamDepartment of Neurology, Royal North Shore Hospital, Sydney, Australia (author)
Skjelland, MonaDepartment of Neurology, Oslo University Hospital, Norway (author)
Almasi-Dooghaee, MostafaDepartment of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran (author)
Cuisenier, PaulineDepartment of Neurology, CHU Grenoble Alpes, France (author)
Murphy, SeánAcute Stroke Service, Mater Misericordiae University Hospital, UCD School of Medicine, RCSI Medical School, Dublin, Ireland (author)
Timsit, SergeDepartment of Neurology, Stroke Unit, Hôpital de la Cavale Blanche, CHRU de Brest (University Hospital), Université de Bretagne Occidentale, Inserm 1078, Brest, France (author)
Coutts, Shelagh B.Department of Clinical Neurosciences Radiology and Community Health Sciences, Foothills Medical Centre, Calgary, Canada (author)
Schönenberger, SilviaDepartment of Neurology, Heidelberg University Hospital, Germany (author)
Nagel, SimonDepartment of Neurology, Heidelberg University Hospital, Germany (author)
Hiltunen, SiniDepartment of Neurology, Helsinki University Hospital, University of Helsinki, Finland (author)
Chatterton, SophieDepartment of Neurology, Royal North Shore Hospital, Sydney, Australia (author)
Cox, ThomasDepartment of Neurology, University Hospital Southampton NHS Foundation Trust, United Kingdom (author)
Bartsch, ThorstenDepartment of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany (author)
Shaygannejad, VahidIsfahan University of Medical Sciences (IUMS), Isfahan Neurosciences Research Center (INRC), Iran (author)
Mirzaasgari, ZahraDepartment of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran (author)
Middeldorp, SaskiaDepartment of Internal Medicine, Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands (author)
Levi, Marcel M.Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Netherlands; National Institute for Health Research, University College London Hospitals (UCLH), Biomedical Research Centre, London, United Kingdom (author)
Kremer Hovinga, Johanna A.Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Switzerland (author)
Jood, KatarinaDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden (author)
Tatlisumak, TurgutDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Neurology, Helsinki University Hospital, University of Helsinki, Finland (author)
Putaala, JukkaDepartment of Neurology, AOU Consorziale Policlinico di Bari, Italy (author)
Heldner, Mirjam R.Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (author)
Arnold, MarcelDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (author)
Aguiar De Sousa, DianaStroke Centre, Lisbon Central University, Hospital Centre, Portugal; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Portugal (author)
Ferro, José M.Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Portugal (author)
Coutinho, Jonathan M.Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Netherlands (author)
Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, NetherlandsDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden (creator_code:org_t)

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In:Stroke: American Heart Association53:10, s. 3206-32100039-24991524-4628

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By the author/editor: Van De Munckhof, ...; Lindgren, Erik; Kleinig, Timothy ...; Field, Thalia S.; Cordonnier, Char ...; Krzywicka, Katar ...; show more...; Poli, Sven; Sánchez Van Kamm ...; Borhani-Haghighi ...; Lemmens, Robin; Scutelnic, Adria ...; Ciccone, Alfonso; Gattringer, Thom ...; Wittstock, Matth ...; Dizonno, Vanessa; Devroye, Annemie; Elkady, Ahmed; Günther, Albrech ...; Cervera, Alvaro; Mengel, Annerose; Chew, Beng Lim A ...; Buck, Brian; Zanferrari, Carl ...; Garcia-Esperon, ...; Jacobi, Christia ...; Soriano, Cristin ...; Michalski, Domin ...; Zamani, Zohreh; Blacquiere, Dyla ...; Johansson, Elias; Cuadrado-Godia, ...; Vuillier, Fabric ...; Bode, Felix J.; Caparros, Franço ...; Maier, Frank; Tsivgoulis, Geor ...; Katzberg, Hans D ...; Duan, Jiangang; Burrow, Jim; Pelz, Johann; Mbroh, Joshua; Oen, Joyce; Schouten, Judith; Zimmermann, Juli ...; Ng, Karl; Garambois, Katia; Petruzzellis, Ma ...; Carvalho Dias, M ...; Ghiasian, Masoud; Romoli, Michele; Miranda, Miguel; Wronski, Miriam; Skjelland, Mona; Almasi-Dooghaee, ...; Cuisenier, Pauli ...; Murphy, Seán; Timsit, Serge; Coutts, Shelagh ...; Schönenberger, S ...; Nagel, Simon; Hiltunen, Sini; Chatterton, Soph ...; Cox, Thomas; Bartsch, Thorste ...; Shaygannejad, Va ...; Mirzaasgari, Zah ...; Middeldorp, Sask ...; Levi, Marcel M.; Kremer Hovinga, ...; Jood, Katarina; Tatlisumak, Turg ...; Putaala, Jukka; Heldner, Mirjam ...; Arnold, Marcel; Aguiar De Sousa, ...; Ferro, José M.; Coutinho, Jonath ...; show less...

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