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Outcomes of cerebra...
Outcomes of cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after the acute phase
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- Van De Munckhof, Anita (author)
- Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Netherlands
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- Lindgren, Erik (author)
- Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Kleinig, Timothy J. (author)
- Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia
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- Field, Thalia S. (author)
- Division of Neurology, Vancouver Stroke Program, University of British Columbia, Vancouver, Canada
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- Cordonnier, Charlotte (author)
- University Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience and Cognition, France
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- Krzywicka, Katarzyna (author)
- Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Netherlands
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- Poli, Sven (author)
- Department of Neurology and Stroke, University Hospital Tuebingen, Eberhard-Karls University, Germany; Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Germany
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- Sánchez Van Kammen, Mayte (author)
- Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Netherlands
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- Borhani-Haghighi, Afshin (author)
- Clinical Neurology Research Center, Shiraz University of Medical Sciences, Iran
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- Lemmens, Robin (author)
- Department of Neurology, University Hospitals Leuven, Belgium
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- Scutelnic, Adrian (author)
- Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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- Ciccone, Alfonso (author)
- Department of Neurology, Carlo Poma Hospital, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy
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- Gattringer, Thomas (author)
- Department of Neurology, Medical University of Graz, Austria
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- Wittstock, Matthias (author)
- Department of Neurology, University Hospital Rostock, Germany
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- Dizonno, Vanessa (author)
- Division of Neurology, Vancouver Stroke Program, University of British Columbia, Vancouver, Canada
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- Devroye, Annemie (author)
- Department of Neurology, University Hospitals Leuven, Belgium
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- Elkady, Ahmed (author)
- Department of Neurology, Saudi German Hospital, Jeddah, Saudi Arabia
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- Günther, Albrecht (author)
- Department of Neurology, Jena University Hospital, Germany
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- Cervera, Alvaro (author)
- Royal Darwin Hospital, NT, Darwin, Australia
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- Mengel, Annerose (author)
- Department of Neurology and Stroke, University Hospital Tuebingen, Eberhard-Karls University, Germany
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- Chew, Beng Lim Alvin (author)
- Department of Neurology, John Hunter Hospital, Newcastle, Australia
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- Buck, Brian (author)
- Division of Neurology, University of Alberta Hospital, Edmonton, Canada
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- Zanferrari, Carla (author)
- Department of Neurology, Azienda Ospedaliera di Melegnano e Della Martesana, Italy
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- Garcia-Esperon, Carlos (author)
- Department of Neurology, John Hunter Hospital, Newcastle, Australia
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- Jacobi, Christian (author)
- Department of Neurology, Krankenhaus Nordwest, Frankfurt am Main, Germany
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- Soriano, Cristina (author)
- Department of Neurology, Hospital General de Castellón, Castelló, Spain
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- Michalski, Dominik (author)
- Department of Neurology, Leipzig University Hospital, Germany
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- Zamani, Zohreh (author)
- Department of Neurology, Firoozabadi Hospital, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
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- Blacquiere, Dylan (author)
- Division of Neurology, Ottawa Hospital, Canada
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- Johansson, Elias (author)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Neurovetenskaper
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- Cuadrado-Godia, Elisa (author)
- Department of Neurology, University Hospital del Mar, Barcelona, Spain
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- Vuillier, Fabrice (author)
- Stroke Unit, University Hospital of Besancon, France
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- Bode, Felix J. (author)
- Department of Neurology, Universitätsklinikum Bonn, Germany
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- Caparros, François (author)
- University Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience and Cognition, France
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- Maier, Frank (author)
- Department of Neurology, Caritas Hospital Saarbrücken, Germany
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- Tsivgoulis, Georgios (author)
- Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Greece
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- Katzberg, Hans D. (author)
- Department of Neuromuscular Medicine, Toronto General Hospital, Canada
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- Duan, Jiangang (author)
- Department of Neurology and Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China
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- Burrow, Jim (author)
- Department of Neurology, Royal Darwin Hospital, Tiwi, Australia
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- Pelz, Johann (author)
- Department of Neurology, Leipzig University Hospital, Germany
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- Mbroh, Joshua (author)
- Department of Neurology and Stroke, University Hospital Tuebingen, Eberhard-Karls University, Germany; Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Germany
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- Oen, Joyce (author)
- Department of Neurology, Antonius Ziekenhuis, Sneek, Netherlands
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- Schouten, Judith (author)
- Department of Neurology, Rijnstate Hospital Arnhem, Netherlands
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- Zimmermann, Julian (author)
- Department of Neurology, Universitätsklinikum Bonn, Germany
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- Ng, Karl (author)
- Department of Neurology, Royal North Shore Hospital, Sydney, Australia
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- Garambois, Katia (author)
- Department of Neurology, CHU Grenoble Alpes, France
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- Petruzzellis, Marco (author)
- Department of Neurology, AOU Consorziale Policlinico di Bari, Italy
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- Carvalho Dias, Mariana (author)
- Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte, University of Lisbon, Portugal
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- Ghiasian, Masoud (author)
- Department of Neurology, Sina Hospital, Hamadan University of Medical Science, Iran
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- Romoli, Michele (author)
- Neurology and Stroke Unit, Department of Neuroscience, Bufalini Hospital, Cesena, Italy
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- Miranda, Miguel (author)
- Department of Neurology, Hospital de Cascais Dr. José de Almeida, Cascais, Portugal
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- Wronski, Miriam (author)
- Department of Neurology, Royal North Shore Hospital, Sydney, Australia
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- Skjelland, Mona (author)
- Department of Neurology, Oslo University Hospital, Norway
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- Almasi-Dooghaee, Mostafa (author)
- Department of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
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- Cuisenier, Pauline (author)
- Department of Neurology, CHU Grenoble Alpes, France
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- Murphy, Seán (author)
- Acute Stroke Service, Mater Misericordiae University Hospital, UCD School of Medicine, RCSI Medical School, Dublin, Ireland
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- Timsit, Serge (author)
- Department of Neurology, Stroke Unit, Hôpital de la Cavale Blanche, CHRU de Brest (University Hospital), Université de Bretagne Occidentale, Inserm 1078, Brest, France
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- Coutts, Shelagh B. (author)
- Department of Clinical Neurosciences Radiology and Community Health Sciences, Foothills Medical Centre, Calgary, Canada
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- Schönenberger, Silvia (author)
- Department of Neurology, Heidelberg University Hospital, Germany
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- Nagel, Simon (author)
- Department of Neurology, Heidelberg University Hospital, Germany
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- Hiltunen, Sini (author)
- Department of Neurology, Helsinki University Hospital, University of Helsinki, Finland
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- Chatterton, Sophie (author)
- Department of Neurology, Royal North Shore Hospital, Sydney, Australia
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- Cox, Thomas (author)
- Department of Neurology, University Hospital Southampton NHS Foundation Trust, United Kingdom
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- Bartsch, Thorsten (author)
- Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany
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- Shaygannejad, Vahid (author)
- Isfahan University of Medical Sciences (IUMS), Isfahan Neurosciences Research Center (INRC), Iran
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- Mirzaasgari, Zahra (author)
- Department of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
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- Middeldorp, Saskia (author)
- Department of Internal Medicine, Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands
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- Levi, Marcel M. (author)
- Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Netherlands; National Institute for Health Research, University College London Hospitals (UCLH), Biomedical Research Centre, London, United Kingdom
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- Kremer Hovinga, Johanna A. (author)
- Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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- Jood, Katarina (author)
- Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Tatlisumak, Turgut (author)
- Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Neurology, Helsinki University Hospital, University of Helsinki, Finland
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- Putaala, Jukka (author)
- Department of Neurology, AOU Consorziale Policlinico di Bari, Italy
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- Heldner, Mirjam R. (author)
- Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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- Arnold, Marcel (author)
- Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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- Aguiar De Sousa, Diana (author)
- Stroke Centre, Lisbon Central University, Hospital Centre, Portugal; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Portugal
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- Ferro, José M. (author)
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Portugal
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- Coutinho, Jonathan M. (author)
- Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Netherlands
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(creator_code:org_t)
- American Heart Association, 2022
- 2022
- English.
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In: Stroke. - : American Heart Association. - 0039-2499 .- 1524-4628. ; 53:10, s. 3206-3210
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Cerebral venous thrombosis (CVT) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe condition, with high in-hospital mortality rates. Here, we report clinical outcomes of patients with CVT-VITT after SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccination who survived initial hospitalization.Methods: We used data from an international registry of patients who developed CVT within 28 days of SARS-CoV-2 vaccination, collected until February 10, 2022. VITT diagnosis was classified based on the Pavord criteria. Outcomes were mortality, functional independence (modified Rankin Scale score 0-2), VITT relapse, new thrombosis, and bleeding events (all after discharge from initial hospitalization).Results: Of 107 CVT-VITT cases, 43 (40%) died during initial hospitalization. Of the remaining 64 patients, follow-up data were available for 60 (94%) patients (37 definite VITT, 9 probable VITT, and 14 possible VITT). Median age was 40 years and 45/60 (75%) patients were women. Median follow-up time was 150 days (interquartile range, 94-194). Two patients died during follow-up (3% [95% CI, 1%-11%). Functional independence was achieved by 53/60 (88% [95% CI, 78%-94%]) patients. No new venous or arterial thrombotic events were reported. One patient developed a major bleeding during follow-up (fatal intracerebral bleed).Conclusions: In contrast to the high mortality of CVT-VITT in the acute phase, mortality among patients who survived the initial hospitalization was low, new thrombotic events did not occur, and bleeding events were rare. Approximately 9 out of 10 CVT-VITT patients who survived the acute phase were functionally independent at follow-up.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- hospitalization
- intracranial thrombosis
- mortality
- thrombocytopenia
- vaccination
- venous thrombosis
- Neurology
- neurologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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Van De Munckhof, ...
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Lindgren, Erik
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Kleinig, Timothy ...
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Field, Thalia S.
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Cordonnier, Char ...
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Krzywicka, Katar ...
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Poli, Sven
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Sánchez Van Kamm ...
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Borhani-Haghighi ...
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Lemmens, Robin
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Scutelnic, Adria ...
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Ciccone, Alfonso
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Gattringer, Thom ...
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Wittstock, Matth ...
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Dizonno, Vanessa
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Devroye, Annemie
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Elkady, Ahmed
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Günther, Albrech ...
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Cervera, Alvaro
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Mengel, Annerose
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Chew, Beng Lim A ...
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Buck, Brian
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Zanferrari, Carl ...
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Garcia-Esperon, ...
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Jacobi, Christia ...
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Soriano, Cristin ...
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Michalski, Domin ...
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Zamani, Zohreh
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Blacquiere, Dyla ...
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Johansson, Elias
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Cuadrado-Godia, ...
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Vuillier, Fabric ...
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Bode, Felix J.
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Caparros, Franço ...
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Maier, Frank
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Tsivgoulis, Geor ...
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Katzberg, Hans D ...
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Duan, Jiangang
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Burrow, Jim
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Pelz, Johann
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Mbroh, Joshua
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Oen, Joyce
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Schouten, Judith
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Zimmermann, Juli ...
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Ng, Karl
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Garambois, Katia
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Petruzzellis, Ma ...
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Carvalho Dias, M ...
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Ghiasian, Masoud
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Romoli, Michele
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Miranda, Miguel
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Wronski, Miriam
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Skjelland, Mona
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Almasi-Dooghaee, ...
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Cuisenier, Pauli ...
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Murphy, Seán
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Timsit, Serge
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Coutts, Shelagh ...
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Schönenberger, S ...
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Nagel, Simon
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Hiltunen, Sini
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Chatterton, Soph ...
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Cox, Thomas
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Bartsch, Thorste ...
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Shaygannejad, Va ...
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Mirzaasgari, Zah ...
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Middeldorp, Sask ...
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Levi, Marcel M.
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Kremer Hovinga, ...
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Jood, Katarina
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Tatlisumak, Turg ...
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Putaala, Jukka
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Heldner, Mirjam ...
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Arnold, Marcel
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Aguiar De Sousa, ...
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Ferro, José M.
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Coutinho, Jonath ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Stroke
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Umeå University