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  • Oldgren, Jonas,1964-Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR) (författare)

Early versus delayed non-vitamin k antagonist oral anticoagulant therapy after acute ischemic stroke in atrial fibrillation (timing) : a registry-based randomized controlled noninferiority study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • American heart association,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-200449
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200449URI
  • https://doi.org/10.1161/CIRCULATIONAHA.122.060666DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-490368URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151216395URI
  • https://lup.lub.lu.se/record/430a56c4-0df7-46eb-92af-c3e36355cc9bURI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: There are no evidence-based recommendations on the optimal time point to initiate non-vitamin K antagonist oral anticoagulants (NOACs) after acute ischemic stroke in patients with atrial fibrillation. We aimed to investigate the efficacy and safety of early versus delayed initiation of NOAC in these patients.METHODS: TIMING (Timing of Oral Anticoagulant Therapy in Acute Ischemic Stroke With Atrial Fibrillation) was a registry-based, randomized, noninferiority, open-label, blinded end-point study at 34 stroke units using the Swedish Stroke Register for enrollment and follow-up. Within 72 hours from stroke onset, patients were randomized to early (≤4 days) or delayed (5-10 days) NOAC initiation, with choice of NOAC at the investigators' discretion. The primary outcome was the composite of recurrent ischemic stroke, symptomatic intracerebral hemorrhage, or all-cause mortality at 90 days. The prespecified noninferiority margin was 3%. Secondary outcomes included the individual components of the primary outcome.RESULTS: Between April 2, 2017, and December 30, 2020, 888 patients were randomized to either early (n=450) or delayed (n=438) initiation of NOAC. No patient was lost to 90-day follow-up. Mean age was 78.3 years (SD, 9.9 years); 46.2% were women; 49.1% had previously known atrial fibrillation; and 17.5% prior stroke. The primary outcome occurred in 31 patients (6.89%) assigned to early initiation and in 38 patients (8.68%) assigned to delayed NOAC initiation (absolute risk difference, -1.79% [95% CI, -5.31% to 1.74%]; Pnoninferiority=0.004). Ischemic stroke rates were 3.11% and 4.57% (risk difference, -1.46% [95% CI, -3.98% to 1.07%]) and all-cause mortality rates were 4.67% and 5.71% (risk difference, -1.04% [95% CI, -3.96% to 1.88%]) in the early and delayed groups, respectively. No patient in either group experienced symptomatic intracerebral hemorrhage.CONCLUSIONS: Early initiation was noninferior to delayed start of NOAC after acute ischemic stroke in patients with atrial fibrillation. Numerically lower rates of ischemic stroke and death and the absence of symptomatic intracerebral hemorrhages implied that the early start of NOAC was safe and should be considered for acute secondary stroke prevention in patients eligible for NOAC treatment. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Åsberg, Signild,1972-Uppsala University,Uppsala universitet,Klinisk epidemiologi(Swepub:uu)sigas493 (författare)
  • Hijazi, ZiadUppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)ziahi940 (författare)
  • Wester, Per,1959-Umeå University,Karolinska Institute,Karolinska Institutet,Umeå universitet,Avdelningen för medicin,Department of Clinical Science, Karolinska Institutet Danderyds sjukhus, Stockholm, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.;Karolinska Inst Danderyds Sjukhus, Dept Clin Sci, Stockholm, Sweden.(Swepub:umu)pewe0002 (författare)
  • Bertilsson, MariaUppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)marbe354 (författare)
  • Norrving, BoLund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Stroke policy och kvalitetsregisterforskning,Clinical Stroke Research Group,Lund University Research Groups,Stroke policy and quality register research,Skåne University Hospital(Swepub:lu)neur-bno (författare)
  • Uppsala universitetKardiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Circulation: American heart association146:14, s. 1056-10660009-73221524-4539

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Oldgren, Jonas,1964-
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