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Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer

Harris, Anna E. (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Metzler, Veronika M. (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Lothion-Roy, Jennifer (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
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Varun, Dhruvika (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Woodcock, Corinne L. (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Haigh, Daisy B. (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Endeley, Chantelle (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Haque, Maria (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Toss, Michael S. (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Alsaleem, Mansour (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; Department of Applied Medical Science, Applied College, Qassim University, Qassim, Saudi Arabia,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.;Qassim Univ, Appl Coll, Dept Appl Med Sci, Qasim, Saudi Arabia.
Persson, Jenny L., Professor (author)
Malmö universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Biomedical Sciences, Malmö Universitet, Malmö, Sweden,Institutionen för biomedicinsk vetenskap (BMV),Umea Univ, Dept Mol Biol, Umea, Sweden.
Gudas, Lorraine J. (author)
Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA.
Rakha, Emad (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Robinson, Brian D. (author)
Department of Urology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Urol, New York, NY USA.
Khani, Francesca (author)
Department of Urology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Urol, New York, NY USA.
Martin, Laura M. (author)
Englander Institute for Precision Medicine, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Englander Inst Precis Med, New York, NY USA.
Moyer, Jenna E. (author)
Englander Institute for Precision Medicine, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Englander Inst Precis Med, New York, NY USA.
Brownlie, Juliette (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Madhusudan, Srinivasan (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Allegrucci, Cinzia (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
James, Victoria H. (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Rutland, Catrin S. (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
Fray, Rupert G. (author)
School of Biosciences, University of Nottingham, Nottingham, United Kingdom,Univ Nottingham, Sch Biosci, Nottingham, England.
Ntekim, Atara (author)
Department of Oncology, University Hospital Ibadan, Ibadan, Nigeria,Univ Hosp Ibadan, Dept Oncol, Ibadan, Nigeria.
de Brot, Simone (author)
Comparative Pathology Platform (COMPATH), Institute of Animal Pathology, University of Bern, Bern, Switzerland,Univ Bern, Inst Anim Pathol, Comparat Pathol Platform COMPATH, Bern, Switzerland.
Mongan, Nigel P. (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.;Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA.
Jeyapalan, Jennie N. (author)
University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom,Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England.
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University of Nottingham Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom Univ Nottingham, Univ Nottingham Biodiscovery Inst, Univ Pk, Nottingham, England (creator_code:org_t)
2022-10-03
2022
English.
In: Frontiers in Endocrinology. - : Frontiers Media S.A.. - 1664-2392. ; 13
Related links:
https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
https://mau.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.3...
https://urn.kb.se/re...
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  • Research review (peer-reviewed)
Abstract Subject headings
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  • Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bicalutamide, enzalutamide, darolutamide). A major limitation of current ADTs is they often remain effective for limited durations after which patients commonly progress to a lethal and incurable form of PCa, called castration-resistant prostate cancer (CRPC) where the AR continues to orchestrate pro-oncogenic signalling. Indeed, the increasing numbers of ADT-related treatment-emergent neuroendocrine-like prostate cancers (NePC), which lack AR and are thus insensitive to ADT, represents a major therapeutic challenge. There is therefore an urgent need to better understand the mechanisms of AR action in hormone dependent disease and the progression to CRPC, to enable the development of new approaches to prevent, reverse or delay ADT-resistance. Interestingly the AR regulates distinct transcriptional networks in hormone dependent and CRPC, and this appears to be related to the aberrant function of key AR-epigenetic coregulator enzymes including the lysine demethylase 1 (LSD1/KDM1A). In this review we summarize the current best status of anti-androgen clinical trials, the potential for novel combination therapies and we explore recent advances in the development of novel epigenetic targeted therapies that may be relevant to prevent or reverse disease progression in patients with advanced CRPC.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Keyword

anti-androgen
castration resistant prostate cancer
epigenetic targeted treatment
PARP inhibitors
Therapy

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