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Pan-cancer analysis...
Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition
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- Breeur, Marie (författare)
- International Agency for Research on Cancer, World Health Organization
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- Ferrari, Pietro (författare)
- International Agency for Research on Cancer, World Health Organization
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- Dossus, Laure (författare)
- International Agency for Research on Cancer, World Health Organization
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visa fler...
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (författare)
- International Agency for Research on Cancer, World Health Organization
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- Rinaldi, Sabina (författare)
- International Agency for Research on Cancer, World Health Organization
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- Travis, Ruth C. (författare)
- University of Oxford
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- His, Mathilde (författare)
- International Agency for Research on Cancer, World Health Organization
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- Key, Tim J. (författare)
- University of Oxford
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- Schmidt, Julie A. (författare)
- University of Oxford,Aarhus University Hospital
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- Overvad, Kim (författare)
- Aarhus University
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Kyrø, Cecilie (författare)
- Danish Cancer Society
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- Rothwell, Joseph A. (författare)
- Versailles Saint-Quentin-en-Yvelines University
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- Laouali, Nasser (författare)
- Versailles Saint-Quentin-en-Yvelines University
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- Severi, Gianluca (författare)
- Versailles Saint-Quentin-en-Yvelines University
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Katzke, Verena (författare)
- German Cancer Research Centre
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- Schulze, Matthias B. (författare)
- German Institute of Human Nutrition
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- Eichelmann, Fabian (författare)
- German Center for Diabetes Research,German Institute of Human Nutrition
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- Palli, Domenico (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Grioni, Sara (författare)
- Istituto Nazionale dei Tumori
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- Panico, Salvatore (författare)
- University of Naples Federico II
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Tumino, Rosario (författare)
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- Sacerdote, Carlotta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Bueno-de-Mesquita, Bas (författare)
- National Institute for Public Health and the Environment (RIVM)
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- Olsen, Karina Standahl (författare)
- UiT The Arctic University of Norway, Tromsø
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- Sandanger, Torkjel Manning (författare)
- UiT The Arctic University of Norway, Tromsø
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- Nøst, Therese Haugdahl (författare)
- UiT The Arctic University of Norway, Tromsø
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- Quirós, J. Ramón (författare)
- Public Health Directorate
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- Bonet, Catalina (författare)
- Bellvitge University Hospital-IDIBELL
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- Barranco, Miguel Rodríguez (författare)
- Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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- Chirlaque, María-Dolores (författare)
- University of Murcia,CIBER Epidemiology and Public Health (CIBERESP)
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- Ardanaz, Eva (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Sandsveden, Malte (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Manjer, Jonas (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Vidman, Linda (författare)
- Umeå University,Umeå universitet,Onkologi
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- Rentoft, Matilda (författare)
- Umeå University,Umeå universitet,Onkologi
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- Muller, David (författare)
- Imperial College London
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- Tsilidis, Kostas (författare)
- Imperial College London
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- Heath, Alicia K. (författare)
- Imperial College London
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- Keun, Hector (författare)
- Imperial College London
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- Adamski, Jerzy (författare)
- University of Ljubljana,Helmholtz Zentrum München,National University of Singapore
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- Keski-Rahkonen, Pekka (författare)
- International Agency for Research on Cancer, World Health Organization
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- Scalbert, Augustin (författare)
- International Agency for Research on Cancer, World Health Organization
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Viallon, Vivian (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2022-10-19
- 2022
- Engelska.
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Ingår i: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 20:1
- Relaterad länk:
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https://doi.org/10.1...
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visa fler...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations.Methods: We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. From pre-diagnostic blood levels of an initial set of 117 metabolites, 33 cluster representatives of strongly correlated metabolites and 17 single metabolites were derived by hierarchical clustering. The mutually adjusted associations of the resulting 50 metabolites with cancer risk were examined in penalized conditional logistic regression models adjusted for body mass index, using the data-shared lasso penalty.Results: Out of the 50 studied metabolites, (i) six were inversely associated with the risk of most cancer types: glutamine, butyrylcarnitine, lysophosphatidylcholine a C18:2, and three clusters of phosphatidylcholines (PCs); (ii) three were positively associated with most cancer types: proline, decanoylcarnitine, and one cluster of PCs; and (iii) 10 were specifically associated with particular cancer types, including histidine that was inversely associated with colorectal cancer risk and one cluster of sphingomyelins that was inversely associated with risk of hepatocellular carcinoma and positively with endometrial cancer risk.Conclusions: These results could provide novel insights for the identification of pathways for cancer development, in particular those shared across different cancer types.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast
- Cancer
- Colorectal
- Endometrial
- EPIC
- Kidney
- Lasso
- Liver
- Metabolomics
- Prostate
- Breast
- Cancer
- Colorectal
- Endometrial
- EPIC
- Kidney
- Lasso
- Liver
- Metabolomics
- Prostate
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Breeur, Marie
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Ferrari, Pietro
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Dossus, Laure
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Jenab, Mazda
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Johansson, Matti ...
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Rinaldi, Sabina
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visa fler...
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Travis, Ruth C.
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His, Mathilde
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Key, Tim J.
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Schmidt, Julie A ...
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Overvad, Kim
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Tjønneland, Anne
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Kyrø, Cecilie
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Rothwell, Joseph ...
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Laouali, Nasser
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Severi, Gianluca
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Kaaks, Rudolf
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Katzke, Verena
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Schulze, Matthia ...
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Eichelmann, Fabi ...
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Palli, Domenico
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Grioni, Sara
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Panico, Salvator ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Bueno-de-Mesquit ...
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Olsen, Karina St ...
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Sandanger, Torkj ...
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Nøst, Therese Ha ...
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Quirós, J. Ramón
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Bonet, Catalina
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Barranco, Miguel ...
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Chirlaque, María ...
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Ardanaz, Eva
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Sandsveden, Malt ...
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Manjer, Jonas
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Vidman, Linda
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Rentoft, Matilda
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Muller, David
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Tsilidis, Kostas
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Heath, Alicia K.
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Keun, Hector
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Adamski, Jerzy
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Keski-Rahkonen, ...
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Scalbert, August ...
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Gunter, Marc J.
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Viallon, Vivian
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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BMC Medicine
- Av lärosätet
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Umeå universitet
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Lunds universitet