Sökning: L773:1477 7819 >
The expression of s...
The expression of stromal biomarkers in small papillary thyroid carcinomas
-
- Bayadsi, Haytham (författare)
- Umeå universitet,Kirurgi
-
- Barghout, George (författare)
- Department of Clinical Pathology, Sunderby Hospital, Sweden
-
- Gustafsson, Moa (författare)
- Umeå universitet,Kirurgi
-
visa fler...
-
- Sund, Malin (författare)
- Umeå universitet,Kirurgi,Clinicum/Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
-
- Hennings, Joakim, 1969- (författare)
- Umeå universitet,Kirurgi
-
visa färre...
-
(creator_code:org_t)
- 2022-10-14
- 2022
- Engelska.
-
Ingår i: World Journal of Surgical Oncology. - : BioMed Central (BMC). - 1477-7819. ; 20:1
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: The importance of stroma for tumor progression is recognized for many cancer types. In this study, we aim to evaluate the expression of types I (Col1) and IV (Col4) collagens, alpha-smooth muscle actin (a-SMA), and matrix metallopeptidase 9 (MMP-9) in the tumor stroma of small papillary thyroid carcinoma (PTC).MATERIAL AND METHODS: Twenty-five non-metastatic small PTCs (pT1N0) and nineteen metastatic small PTCs (pT1N1b) including corresponding metastatic lateral lymph nodes were selected and paraffinized tissue blocks retrieved. The samples were stained for Col1, COL4, a-SMA, and MMP-9 antibodies using immunohistochemistry. The expression of the stromal proteins was scored and analyzed based on the location, intensity, and distribution.RESULTS: Col1 and Col4 expression were significantly higher in normal thyroid tissue compared to PTC tissue. On the contrary, expression of a-SMA and MMP-9 was higher in PTC tissue compared to normal thyroid tissue. Both Col1 and Col4 were significantly more highly expressed in the non-metastatic tumors compared with metastatic tumors. The expression of a-SMA and MMP9 was slightly, but not significantly, higher in the metastasized tumors and their respective lymph nodes. There was a significant correlation between the metastasized tumors and their respective lymph nodes in Col1 and MMP-9 expression.CONCLUSIONS: Col1, Col4, a-SMA, and MMP-9 expression in PTCs differs significantly from that of normal thyroid tissue. The higher expression of Col1 and Col4 in normal thyroid tissue and in the non-metastasized tumors indicates that Col1 and 4 might have a potential protective role in tumor progression. The higher expression of a-SMA and MMP9 in PTCs indicates that these proteins might have a role in promoting PTC progression and aggressiveness.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Alpha-smooth muscle actin
- Matrix metallopeptidase 9
- Papillary thyroid cancer
- Tumor stroma
- Type 1 collagen
- Type IV collagen
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas