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Sökning: WFRF:(Sandanger Torkjel) > (2023) > Assessment of the E...

Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers : A retrospective nested case-control study in two prospective cohorts

Wu, Wendy Yi-Ying (författare)
Umeå universitet,Onkologi
Haider, Zahra (författare)
Umeå universitet,Onkologi
Feng, Xiaoshuang (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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Heath, Alicia K. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Tjønneland, Anne (författare)
Diet, Cancer and Health, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Agudo, Antonio (författare)
Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Barcelona, Spain; Nutrition and Cancer Group, Epidemiology, Public Health Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
Masala, Giovanna (författare)
Institute for Cancer Research Prevention and Clinical Network (ISPRO), Florence, Italy
Robbins, Hilary A. (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Huerta, María-José (författare)
Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Guevara, Marcela (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Schulze, Matthias B. (författare)
German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
Rodriguez-Barranco, Miguel (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain
Vineis, Paolo (författare)
MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom
Tumino, Rosario (författare)
Hyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany; Translational Lung Research Center (TLRC) Heidelberg, Member of the German Center for Lung Research (DZL), Heidelberg, Germany
Fortner, Renée T. (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany
Sieri, Sabina (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy
Panico, Salvatore (författare)
Dipartimento di Medicina Clinica e Chirurgia Federico II Universioty, Naples, Italy
Nøst, Therese Haugdahl (författare)
Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
Sandanger, Torkjel M. (författare)
Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
Braaten, Tonje (författare)
Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
Johansson, Mattias (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Melin, Beatrice S. (författare)
Umeå universitet,Onkologi
Johansson, Mikael (författare)
Umeå universitet,Onkologi
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 (creator_code:org_t)
2022-11-05
2023
Engelska.
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 152:9, s. 2002-2010
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung test using prediagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a prediagnostic blood sample <3 years prior to diagnosis. Conditional logistic regression was used to estimate the association between EarlyCDT-Lung test results and lung cancer risk. Sensitivity and specificity of the EarlyCDT-Lung test were calculated in all subjects and subgroups based on age, smoking history, lung cancer stage, sample collection time before diagnosis and year of sample collection. The overall lung cancer odds ratios were 0.89 (95% CI: 0.34-2.30) for a moderate risk EarlyCDT-Lung test result and 1.09 (95% CI: 0.48-2.47) for a high-risk test result compared to no significant test result. The overall sensitivity was 8.4% (95% CI: 4.6-14) and overall specificity was 92% (95% CI: 87-96) when considering a high-risk result as positive. Stratified analysis indicated higher sensitivity (17%, 95% CI: 7.2-32.1) in subjects with blood drawn up to 1 year prior to diagnosis. In conclusion, our study does not support a role of the EarlyCDT-Lung test in identifying the high-risk subjects in ever-smokers for lung cancer screening in the EPIC and NSHDS cohorts.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

biomarkers
EarlyCDT-Lung test
lung cancer
prediagnostic samples

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art (ämneskategori)

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